Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control

Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors

(2021) Chuanxiong Nie et al.   Science Advances

No higher infectivity but immune escape of SARS-CoV-2 501Y.V2 variants

(2021) Qianqian Li et al.   CELL

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera

(2021) Daming Zhou et al.   CELL

Formulation development and in vitro evaluation of transferrin-conjugated liposomes as a carrier of ganciclovir targeting the retina

(2020) Rathapon Asasutjarit et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Medicinal chemistry strategies toward host targeting antiviral agents

(2020) Xingyue Ji et al.   MEDICINAL RESEARCH REVIEWS

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

Connecting hydroxychloroquine in vitro antiviral activity to in vivo concentration for prediction of antiviral effect: a critical step in treating COVID-19 patients

(2020) Jianghong Fan et al.   CLINICAL INFECTIOUS DISEASES

Induction of Robust Immune Responses by CpG-ODN-Loaded Hollow Polymeric Nanoparticles for Antiviral and Vaccine Applications in Chickens

(2020) Shu-Yi Lin et al.   International Journal of Nanomedicine

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

(2020) Wenling Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

COVID-19 and emerging viral infections: The case for interferon lambda

(2020) Ludmila Prokunina-Olsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy

(2020) Saborni Chattopadhyay et al.   NANO LETTERS

A year-long extended release nanoformulated cabotegravir prodrug

(2020) Tanmay A. Kulkarni et al.   NATURE MATERIALS

Insights from nanomedicine into chloroquine efficacy against COVID-19

(2020) Tony Y. Hu et al.   Nature Nanotechnology

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

An Elvitegravir Nanoformulation Crosses the Blood–Brain Barrier and Suppresses HIV-1 Replication in Microglia

(2020) Yuqing Gong et al.   Viruses-Basel

Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

(2020) Mahmoud Nasrollahzadeh et al.   Nanomaterials

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound?

(2020) Dominique Batisse et al.   JOURNAL OF INFECTION

Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition

(2020) Chuanxiong Nie et al.   NANO LETTERS

Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

(2020) Qiangzhe Zhang et al.   NANO LETTERS

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

(2020) Pauline Maisonnasse et al.   NATURE

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Nanotechnology-based disinfectants and sensors for SARS-CoV-2

(2020) Sepehr Talebian et al.   Nature Nanotechnology

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19 Vaccine Frontrunners and Their Nanotechnology Design

(2020) Young Hun Chung et al.   ACS Nano

COVID has killed more than one million people. How many more will die?

(2020) Emiliano Rodríguez Mega   NATURE

Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

(2020) Lang Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Feline infectious peritonitis (FIP) and coronavirus disease 19 (COVID‐19): Are they similar?

(2020) Saverio Paltrinieri et al.   Transboundary and Emerging Diseases

CD4+ T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy

(2020) Gang Zhang et al.   mBio

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

(2020) Jinsung Yang et al.   Nature Communications

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

Nanotechnology Responses to COVID‐19

(2020) Eduardo Ruiz‐Hitzky et al.   Advanced Healthcare Materials

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

(2020) Sangiliyandi Gurunathan et al.   Nanomaterials

A materials-science perspective on tackling COVID-19

(2020) Zhongmin Tang et al.   Nature Reviews Materials

A Strategy to Treat COVID‐19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study

(2020) Tien‐Tzu Tai et al.   CTS-Clinical and Translational Science

Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination

(2020) Saborni Chattopadhyay et al.   Nanomedicine

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

(2020) Andre C. Kalil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases

(2020) Zongmin Zhao et al.   Nature Biomedical Engineering

Nanotechnology for virus treatment

(2020) Jiarong Zhou et al.   Nano Today

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Nano-encapsulation and characterization of baricitinib using poly-lactic-glycolic acid co-polymer

(2019) Mohammad Javed Ansari et al.   SAUDI PHARMACEUTICAL JOURNAL

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

(2019) James J. Hobson et al.   Nature Communications

Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

(2019) Leon Chien‐Wei Lin et al.   ADVANCED FUNCTIONAL MATERIALS

A potential long-acting bictegravir loaded nano-drug delivery system for HIV-1 infection: A proof-of-concept study

(2019) Subhra Mandal et al.   ANTIVIRAL RESEARCH

Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures

(2019) Hongliang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

(2019) Alicia Martinez-Lopez et al.   EBioMedicine

A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy

(2019) Wesley L. Fotoran et al.   Nanomedicine-Nanotechnology Biology and Medicine

Long-acting parenteral combination antiretroviral loaded nano-drug delivery system to treat chronic HIV-1 infection: A humanized mouse model study

(2018) Subhra Mandal et al.   ANTIVIRAL RESEARCH

Probing Molecular Insights into Zika Virus–Host Interactions

(2018) Ina Lee et al.   Viruses-Basel

T-Cell-Mimicking Nanoparticles Can Neutralize HIV Infectivity

(2018) Xiaoli Wei et al.   ADVANCED MATERIALS

Bioinspired Artificial Nanodecoys for Hepatitis B Virus

(2018) Xuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Viral escape from endosomes and host detection at a glance

(2018) Jacqueline Staring et al.   JOURNAL OF CELL SCIENCE

RNA Interference as a Prospective Tool for the Control of Human Viral Infections

(2018) Alesia Levanova et al.   Frontiers in Microbiology

Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection

(2018) Che-Ming Jack Hu et al.   International Journal of Nanomedicine

A Biomimetic Nanodecoy Traps Zika Virus To Prevent Viral Infection and Fetal Microcephaly Development

(2018) Lang Rao et al.   NANO LETTERS

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1

(2017) Chukwuemika Aroh et al.   JOURNAL OF IMMUNOLOGY

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

(2017) Soracha Thamphiwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting influenza virus replication and inducing protection against lethal influenza virus challenge through chitosan nanoparticles loaded by siRNA

(2017) Abbas Jamali et al.   Drug Delivery and Translational Research

Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus

(2017) Che-Ming Jack Hu et al.   Scientific Reports

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

(2017) Joy Wolfram et al.   Scientific Reports

An Enhanced Emtricitabine-Loaded Long-Acting Nanoformulation for Prevention or Treatment of HIV Infection

(2016) Subhra Mandal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nanostructured glycan architecture is important in the inhibition of influenza A virus infection

(2016) Seok-Joon Kwon et al.   Nature Nanotechnology

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus

(2016) Lyle R. Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Triple Drug Combination of Zidovudine, Efavirenz and Lamivudine Loaded Lactoferrin Nanoparticles: an Effective Nano First-Line Regimen for HIV Therapy

(2016) Prashant Kumar et al.   PHARMACEUTICAL RESEARCH

Anticancer Platelet-Mimicking Nanovehicles

(2015) Quanyin Hu et al.   ADVANCED MATERIALS

Anti-HIV Drug-Combination Nanoparticles Enhance Plasma Drug Exposure Duration as Well as Triple-Drug Combination Levels in Cells Within Lymph Nodes and Blood in Primates

(2015) Jennifer P. Freeling et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations

(2015) Pavan Puligujja et al.   BIOMATERIALS

PLGA-PEG Nanoparticles Coated with Anti-CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread

(2015) Xiaolong Tang et al.   Nanoscale Research Letters

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

(2015) Emily P. Thi et al.   NATURE

Virus-mimetic nanovesicles as a versatile antigen-delivery system

(2015) Pengfei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance

(2015) Lang Rao et al.   Small

PLGA-PEG Nanoparticles Coated with Anti-CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread

(2015) Xiaolong Tang et al.   Nanoscale Research Letters

Evaluation of Atazanavir and Darunavir Interactions with Lipids for Developing pH-Responsive Anti-HIV Drug Combination Nanoparticles

(2014) Jinghua Duan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection

(2014) Julianne V. de Carvalho et al.   PLoS One

Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

(2013) Luis M. Bimbo et al.   ACS Nano

Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes

(2013) Weiwei Gao et al.   ADVANCED MATERIALS

Polymeric Nanoparticles Containing Combination Antiretroviral Drugs for HIV Type 1 Treatment

(2013) Annemarie Shibata et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses

(2013) Hui-Wen Chen et al.   ANTIVIRAL RESEARCH

Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles

(2013) Brian T. Luk et al.   Nanoscale

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Nanoparticle-detained toxins for safe and effective vaccination

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

(2012) Prasanta K. Dash et al.   AIDS

Chemico-physical investigation of tenofovir loaded polymeric nanoparticles

(2012) Daniela Belletti et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polymer nanoparticles encapsulating siRNA for treatment of HSV-2 genital infection

(2012) Jill M. Steinbach et al.   JOURNAL OF CONTROLLED RELEASE

Tropism and Infectivity of Influenza Virus, Including Highly Pathogenic Avian H5N1 Virus, in Ferret Tracheal Differentiated Primary Epithelial Cell Cultures

(2012) H. Zeng et al.   JOURNAL OF VIROLOGY

Amantadine: The journey from fighting flu to treating Parkinson disease

(2012) G. Hubsher et al.   NEUROLOGY

Inhibiting host–pathogen interactions using membrane-based nanostructures

(2012) Daniel A. Bricarello et al.   TRENDS IN BIOTECHNOLOGY

Interferons as Therapeutic Agents for Infectious Diseases

(2011) Scott J. Bergman et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Cell derived liposomes expressing CCR5 as a new targeted drug-delivery system for HIV infected cells

(2011) Tomer Bronshtein et al.   JOURNAL OF CONTROLLED RELEASE

Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine

(2011) José das Neves et al.   PHARMACEUTICAL RESEARCH

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of cationic nanoparticles of biodegradable copolymers as siRNA delivery system for hepatitis B treatment

(2010) Junping Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Influenza Virus Infection by Multivalent Sialic-Acid-Functionalized Gold Nanoparticles

(2010) Ilona Papp et al.   Small

The NCI Alliance for Nanotechnology in Cancer: achievement and path forward

(2010) Krzysztof Ptak et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice

(2009) E. Keyaerts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes

(2009) Reginald Clayton et al.   ANTIVIRAL RESEARCH

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

NanoART synthesis, characterization, uptake, release and toxicology for human monocyte–macrophage drug delivery

(2009) Ari S Nowacek et al.   Nanomedicine

Targeted delivery of nanoparticles for the treatment of lung diseases

(2008) Shirzad Azarmi et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted delivery of siRNA against hepatitis C virus by apolipoprotein A-I-bound cationic liposomes

(2008) Soo In Kim et al.   JOURNAL OF HEPATOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Liver targeting and anti-HBV activity of reconstituted HDL–acyclovir palmitate complex

(2007) M FENG   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS