Insights from nanomedicine into chloroquine efficacy against COVID-19

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

(2020) Jianjun Gao et al.   BioScience Trends

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

Clinical cancer nanomedicine

(2019) Joy Wolfram et al.   Nano Today

Chloroquine and nanoparticle drug delivery: A promising combination

(2018) Joe Pelt et al.   PHARMACOLOGY & THERAPEUTICS

Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection

(2018) Pierre Roques et al.   Viruses-Basel

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

(2017) Joy Wolfram et al.   Scientific Reports

CALM Regulates Clathrin-Coated Vesicle Size and Maturation by Directly Sensing and Driving Membrane Curvature

(2015) Sharon E. Miller et al.   DEVELOPMENTAL CELL

Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model

(2015) Stuart D. Dowall et al.   JOURNAL OF GENERAL VIROLOGY

Liposomal chemotherapeutics

(2013) Emanuela Gentile et al.   Future Oncology

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice

(2009) E. Keyaerts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

(2009) K. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH