Medicinal chemistry strategies toward host targeting antiviral agents

Concept of Viral Inhibitors via NTCP

(2019) Kento Fukano et al.   SEMINARS IN LIVER DISEASE

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells

(2019) Sujit Pujhari et al.   Emerging Microbes & Infections

Is tetherin a true antiviral: The influenza a virus controversy

(2019) Anshika Sharma et al.   REVIEWS IN MEDICAL VIROLOGY

Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates

(2019) Yixuan Wang et al.   MOLECULES

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

(2019) Christopher R. M. Asquith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I

(2019) Zhou-Yi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design, synthesis, and biological evaluation of 2-amino-N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif inhibitors

(2019) Rong-Hong Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview

(2019) Manoj Dhameja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Small molecule grp94 inhibitors block dengue and Zika virus replication

(2019) Hussin A. Rothan et al.   ANTIVIRAL RESEARCH

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens

(2018) Xiao Tong et al.   ANTIVIRAL RESEARCH

Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide

(2018) Yasunori Nio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs

(2018) Stanford Schor et al.   DNA AND CELL BIOLOGY

Final results of a multicenter, open-label phase 2b clinical trial to assess safety and efficacy of Myrcludex B in combination with Tenofovir in patients with chronic HBV/HDV co-infection

(2018) H. Wedemeyer et al.   JOURNAL OF HEPATOLOGY

Optimization of Isothiazolo[4,3-b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity

(2018) Szu-Yuan Pu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dauricine combined with clindamycin inhibits severe pneumonia co-infected by influenza virus H5N1 and Streptococcus pneumoniae in vitro and in vivo through NF-κB signaling pathway

(2018) Hui Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Recent Advancement of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy

(2018) Debasis Das et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cyclophilins and cyclophilin inhibitors in nidovirus replication

(2018) Adriaan H. de Wilde et al.   VIROLOGY

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

(2018) Anuj Khandelwal et al.   Nature Communications

Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response

(2018) Wen Dang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57

(2018) Sara Piacentini et al.   Scientific Reports

Farnesoid X receptor-α is a proviral host factor for hepatitis B virus that is inhibited by ligands in vitro and in vivo

(2018) Karim Mouzannar et al.   FASEB JOURNAL

New connections: Kinase inhibitors as antivirals

(2018) Erin R. Williams   Science Signaling

Synthesis and pre-clinical studies of new amino-acid ester thiazolide prodrugs

(2017) Andrew V. Stachulski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells

(2017) S. Joly et al.   JOURNAL OF HEPATOLOGY

Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

(2017) Satomi Shimura et al.   JOURNAL OF HEPATOLOGY

Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction

(2017) Julia Ma et al.   ACS Medicinal Chemistry Letters

Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates

(2016) Carolina Herrera et al.   AIDS

Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier of drug resistance

(2016) Chunlong Ma et al.   ANTIVIRAL RESEARCH

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

(2016) Matthew K. Howe et al.   ANTIVIRAL RESEARCH

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

(2016) H. Marie Loughran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV

(2016) Michelle B. Kim et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors

(2016) Sheng Tang et al.   Future Medicinal Chemistry

Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly

(2016) Ronik Khachatoorian et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1

(2016) Xing-Yue Ji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epigallocatechin gallate inhibits hepatitis B virus via farnesoid X receptor alpha

(2016) Jun Xu et al.   Journal of Natural Medicines

Ribavirin revisited in the era of direct-acting antiviral therapy for hepatitis C virus infection

(2016) Jordan J. Feld et al.   LIVER INTERNATIONAL

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals

(2016) Alessandro T. Caputo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2-thio-6-azauridine inhibits Vpu mediated BST-2 degradation

(2016) Quan Zhang et al.   Retrovirology

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

(2016) Abdelhakim Ahmed-Belkacem et al.   Nature Communications

HPIDB 2.0: a curated database for host–pathogen interactions

(2016) Mais G. Ammari et al.   Database-The Journal of Biological Databases and Curation

A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial

(2016) Edward Gane et al.   ACS Infectious Diseases

Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus

(2016) Jean-François Rossignol   Journal of Infection and Public Health

Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif–APOBEC3G complex

(2015) Shaoyang Zhang et al.   ANTIVIRAL RESEARCH

Zinc finger antiviral protein inhibits coxsackievirus B3 virus replication and protects against viral myocarditis

(2015) Min Li et al.   ANTIVIRAL RESEARCH

Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication

(2015) Chunsheng Dong et al.   ANTIVIRAL RESEARCH

Repurposing Kinase Inhibitors as Antiviral Agents to Control Influenza A Virus Replication

(2015) Olivia Perwitasari et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]–APOA1–HBx–Beclin1-mediated autophagic pathway in HBV therapy

(2015) Jin Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists

(2015) Suwen Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp.

(2015) Hiroki Matsunaga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

(2015) G. M. Bol et al.   EMBO Molecular Medicine

Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein

(2015) Ting Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

P0890 : Novel cyclophilin inhibitor CPI-431-32 shows broad spectrum antiviral activity by blocking replication of HCV, HBV and HIV-1 viruses

(2015) P. Gallay et al.   JOURNAL OF HEPATOLOGY

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents

(2015) Sona Kovackova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses

(2015) Surender Vashist et al.   JOURNAL OF VIROLOGY

Dengue Virus Evolution under a Host-Targeted Antiviral

(2015) Emily Plummer et al.   JOURNAL OF VIROLOGY

Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome

(2015) Charles Daniel Meyers et al.   Lipids in Health and Disease

Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase: synthesis, structure–activity relationship studies and antiviral activity

(2015) Jiahong Li et al.   MedChemComm

Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer

(2015) Sabindra K. Samal et al.   Scientific Reports

A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2

(2015) Zeyun Mi et al.   Scientific Reports

Synthesis and antiviral activity of a series of novel N-phenylbenzamide and N-phenylacetophenone compounds as anti-HCV and anti-EV71 agents

(2015) Zhi Jiang et al.   Acta Pharmaceutica Sinica B

In Vivo Therapeutic Protection against Influenza A (H1N1) Oseltamivir-Sensitive and Resistant Viruses by the Iminosugar UV-4

(2015) Eric J. Stavale et al.   PLoS One

Host APOBEC3G Protein Inhibits HCV Replication through Direct Binding at NS3

(2015) Yan-Ping Zhu et al.   PLoS One

Design, Synthesis and Structure-Activity Relationship Optimization of Lycorine Derivatives for HCV Inhibition

(2015) Duozhi Chen et al.   Scientific Reports

Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2

(2014) Xuesen Zhao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Effect of Nitazoxanide with Neuraminidase Inhibitors against Influenza A VirusesIn Vitro

(2014) Giuseppe Belardo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nitazoxanide: A first-in-class broad-spectrum antiviral agent

(2014) Jean-François Rossignol   ANTIVIRAL RESEARCH

Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle

(2014) Matthieu Blanchet et al.   ANTIVIRAL RESEARCH

The competitive binding between inhibitors and substrates of HCV NS3/4A protease: A general mechanism of drug resistance

(2014) Yan Guan et al.   ANTIVIRAL RESEARCH

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

(2014) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB

(2014) Kai Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel peptide to disrupt the interaction of BST-2 and Vpu

(2014) Zeyun Mi et al.   BIOPOLYMERS

Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

(2014) Matthew K. Howe et al.   CHEMISTRY & BIOLOGY

Targeting Chemokine Receptor CXCR4 for Treatment of HIV-1 Infection, Tumor Progression, and Metastasis

(2014) Won-Tak Choi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Interferon Regulatory Factor-1 (IRF-1) Is Involved in the Induction of Phosphatidylserine Receptor (PSR) in Response to dsRNA Virus Infection and Contributes to Apoptotic Cell Clearance in CHSE-214 Cell

(2014) Hsin-Chia Kung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analyzing the relationship of QT interval and exposure toNitazoxanide, a prospective candidate for influenza antiviral therapy-A formal TQT study

(2014) Jörg Täubel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

(2014) Tony Taldone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatitis C Virus Entry Is Impaired by Claudin-1 Downregulation in Diacylglycerol Acyltransferase-1-Deficient Cells

(2014) P. S. Sung et al.   JOURNAL OF VIROLOGY

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses

(2014) Z. Han et al.   JOURNAL OF VIROLOGY

Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial

(2014) Jason Haffizulla et al.   LANCET INFECTIOUS DISEASES

Synthesis and Broad-Spectrum Antiviral Activity of Some Novel Benzo-Heterocyclic Amine Compounds

(2014) Da-Jun Zhang et al.   MOLECULES

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro

(2014) Jintao Gao et al.   Virology Journal

Comparative quantitative monitoring of rabbit haemorrhagic disease viruses in rabbit kittens

(2014) Markus Matthaei et al.   Virology Journal

Small molecules that inhibit Vif-induced degradation of APOBEC3G

(2014) Masashi Matsui et al.   Virology Journal

Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents

(2014) Yinghong Li et al.   Acta Pharmaceutica Sinica B

Intensification of a raltegravir-based regimen with maraviroc in early HIV-1 infection

(2013) Maria C. Puertas et al.   AIDS

Virological and Immunological Response to Antiretroviral Regimens Containing Maraviroc in HIV Type 1-Infected Patients in Clinical Practice: Role of Different Tropism Testing Results and of Concomitant Treatments

(2013) Barbara Rossetti et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

(2013) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP

(2013) Masashi Iwamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70)

(2013) Duo-Zhi Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Indolizine Derivatives as HIV-1 VIF-ElonginC Interaction Inhibitors

(2013) Wenlin Huang et al.   Chemical Biology & Drug Design

Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenyl amines

(2013) Zhao-Jin Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Diacylglycerol Acyltransferase-1 Localizes Hepatitis C Virus NS5A Protein to Lipid Droplets and Enhances NS5A Interaction with the Viral Capsid Core

(2013) Gregory Camus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor

(2013) Shirin Nkongolo et al.   JOURNAL OF HEPATOLOGY

Nuclear Transport of Epstein-Barr Virus DNA Polymerase Is Dependent on the BMRF1 Polymerase Processivity Factor and Molecular Chaperone Hsp90

(2013) D. Kawashima et al.   JOURNAL OF VIROLOGY

Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors

(2013) Xing-Yue Ji et al.   MOLECULES

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus

(2013) Ron Geller et al.   PLoS One

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

HIV: Cell Binding and Entry

(2013) C. B. Wilen et al.   Cold Spring Harbor Perspectives in Medicine

Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial

(2012) Satoru Watanabe et al.   ANTIVIRAL RESEARCH

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

(2012) Marco Radi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions

(2012) David S. Hong et al.   CANCER TREATMENT REVIEWS

Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication

(2012) Akbar Ali et al.   ChemMedChem

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors

(2012) Lan-hu Hao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo

(2012) Yu-Huan Li et al.   JOURNAL OF ANTIBIOTICS

Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation

(2012) L. R. Keyes et al.   JOURNAL OF GENERAL VIROLOGY

The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

(2012) Sam Hopkins et al.   JOURNAL OF HEPATOLOGY

Development of a Grp94 inhibitor

(2012) Adam S. Duerfeldt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC

(2012) T. Zuo et al.   JOURNAL OF VIROLOGY

The hERG Channel Is Dependent upon the Hsp90α Isoform for Maturation and Trafficking

(2012) Laura B. Peterson et al.   MOLECULAR PHARMACEUTICS

Antiviral Effect of Matrine against Human Enterovirus 71

(2012) Yajun Yang et al.   MOLECULES

Systematic identification of synergistic drug pairs targeting HIV

(2012) Xu Tan et al.   NATURE BIOTECHNOLOGY

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

(2012) Bruno Sainz et al.   NATURE MEDICINE

P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication

(2012) Harendra S. Chahar et al.   VIROLOGY

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

(2012) Gregory Neveu et al.   PLoS Pathogens

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

(2011) Ming Li et al.   ACS Chemical Biology

Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

(2011) Matthew A. Gregory et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-throughput assay to identify inhibitors of Vpu-mediated down-regulation of cell surface BST-2

(2011) Quan Zhang et al.   ANTIVIRAL RESEARCH

Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy

(2011) Eric Lawitz et al.   ANTIVIRAL RESEARCH

Synthesis, structure−activity relationship and biological evaluation of novel N-substituted matrinic acid derivatives as host heat-stress cognate 70 (Hsc70) down-regulators

(2011) Na-Na Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

(2011) Renato Skerlj et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

(2011) Giovanni Maga et al.   ChemMedChem

Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication

(2011) A. Garbelli et al.   CURRENT MEDICINAL CHEMISTRY

Chemokine control of West Nile virus infection

(2011) Jean K. Lim et al.   EXPERIMENTAL CELL RESEARCH

Host apolipoprotein b messenger RNA-editing enzyme catalytic polypeptide-like 3G is an innate defensive factor and drug target against hepatitis C virus

(2011) Zong-Gen Peng et al.   HEPATOLOGY

Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism

(2011) Jonathan Goldwasser et al.   JOURNAL OF HEPATOLOGY

Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

(2011) Wieslaw M. Kazmierski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70

(2011) Li-Mei Gao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heat Shock Protein 70 Inhibits the Activity of Influenza A Virus Ribonucleoprotein and Blocks the Replication of Virus In Vitro and In Vivo

(2011) Gang Li et al.   PLoS One

Ribavirin-Induced Anemia in Hepatitis C Virus Patients Undergoing Combination Therapy

(2011) Sheeja M. Krishnan et al.   PLoS Computational Biology

Total synthesis of cajanine and its antiproliferative activity against human hepatoma cells

(2011) Xing-yue Ji et al.   Acta Pharmaceutica Sinica B

Inhibition of heat-shock protein 90 reduces Ebola virus replication

(2010) Darci R. Smith et al.   ANTIVIRAL RESEARCH

Strategies for development of dengue virus inhibitors

(2010) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1

(2010) John G. Catalano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA

(2010) Zong-Gen Peng et al.   HEPATOLOGY

A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: synthesis, structure–activity relationships and anti-HCV activity in GS4.3 replicon cells

(2010) Guang-zhi Shan et al.   JOURNAL OF ANTIBIOTICS

Small Molecular Compounds Inhibit HIV-1 Replication through Specifically Stabilizing APOBEC3G

(2010) Shan Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90

(2010) Andrew J. Massey   JOURNAL OF MEDICINAL CHEMISTRY

An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery ofN-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

(2010) Paul A. Stupple et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu

(2010) C. Goffinet et al.   JOURNAL OF VIROLOGY

Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin

(2010) Sheli R. Radoshitzky et al.   JOURNAL OF VIROLOGY

Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers

(2010) Hee Youn Shim et al.   VIROLOGY

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

(2010) Chu-Biao Xue et al.   ACS Medicinal Chemistry Letters

Blockade of X4-Tropic HIV-1 Cellular Entry by GSK812397, a Potent Noncompetitive CXCR4 Receptor Antagonist

(2009) S. Jenkinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

(2009) S. Hopkins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication

(2009) Xiaoling Liu et al.   CELLULAR MICROBIOLOGY

Plerixafor

(2009) Antona J. Wagstaff   DRUGS

The Anti-Hepatitis C Agent Nitazoxanide Induces Phosphorylation of Eukaryotic Initiation Factor 2α Via Protein Kinase Activated by Double-Stranded RNA Activation

(2009) Menashe Elazar et al.   GASTROENTEROLOGY

Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonresponders

(2009) Vinod K. Rustgi et al.   HEPATOLOGY

A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment-naïve patients with chronic hepatitis C: ViSER1 results

(2009) Yves Benhamou et al.   HEPATOLOGY

The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity

(2009) Romain Parent et al.   HEPATOLOGY

Safety and efficacy of viramidine versus ribavirin in ViSER2: Randomized, double-blind study in therapy-naive hepatitis C patients

(2009) Patrick Marcellin et al.   JOURNAL OF HEPATOLOGY

Heat Shock Protein 90: Inhibitors in Clinical Trials

(2009) Marco A. Biamonte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Mechanism of BST2/Tetherin Downregulation by K5/MIR2 of Kaposi's Sarcoma-Associated Herpesvirus

(2009) M. Mansouri et al.   JOURNAL OF VIROLOGY

Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein

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