Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective

Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease

(2020) Julio M. Martinez-Moreno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells

(2020) Guangzhi Li et al.   LIFE SCIENCES

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

(2019) Guochun Chen et al.   KIDNEY INTERNATIONAL

Long noncoding RNA NONHSAG053901 promotes diabetic nephropathy via stimulating Egr‐1/TGF‐β‐mediated renal inflammation

(2019) Wenfang Peng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

circLRP6 regulates high glucose‐induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells

(2019) Bin Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

(2019) Monika A. Niewczas et al.   NATURE MEDICINE

Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

(2019) Fangfang Zha et al.   Aging-US

Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease

(2019) Jia Guo et al.   CLINICAL SCIENCE

Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease

(2019) Keiichiro Matoba et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long non-coding RNA Rpph1 promotes inflammation and proliferation of mesangial cells in diabetic nephropathy via an interaction with Gal-3

(2019) Panyang Zhang et al.   Cell Death & Disease

Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

(2019) Caroline Gluck et al.   Nature Communications

Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1

(2019) Dong-Wei Liu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Circ_0080425 inhibits cell proliferation and fibrosis in diabetic nephropathy via sponging miR‐24‐3p and targeting fibroblast growth factor 11

(2019) Huifang Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Definition, Classification and Diagnosis of Diabetes Mellitus

(2019) Astrid Petersmann et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy

(2018) Jian Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy

(2018) Junjie Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy

(2018) Shan Wang et al.   CELL PROLIFERATION

Badanie zależności między metylacją regionu promotora genu MMP-9 a nefropatią cukrzycową

(2018) Xiao-Hui Yang et al.   Endokrynologia Polska

Up-regulation of microRNA-93 inhibits TGF-β1-induced EMT and renal fibrogenesis by down-regulation of Orai1

(2018) Jifang Ma et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cytosine methylation predicts renal function decline in American Indians

(2018) Chengxiang Qiu et al.   KIDNEY INTERNATIONAL

Effect of TET2 on the pathogenesis of diabetic nephropathy through activation of transforming growth factor β1 expression via DNA demethylation

(2018) liling Yang et al.   LIFE SCIENCES

JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial

(2018) Katherine R Tuttle et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

(2018) Ailing Li et al.   Cell Death & Disease

LncRNA LINC00968 accelerates the proliferation and fibrosis of diabetic nephropathy by epigenetically repressing p21 via recruiting EZH2

(2018) Zhenjin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-423-5p suppresses high-glucose-induced podocyte injury by targeting Nox4

(2018) Yuxiang Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression

(2018) Xiaoping Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy

(2018) Zhiqiang Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-β1

(2018) Wei Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Angiopoietin-like protein 2 promotes the progression of diabetic kidney disease

(2018) Toshihisa Ishii et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Biogenesis, Functions, and Challenges of Circular RNAs

(2018) Xiang Li et al.   MOLECULAR CELL

lncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy

(2018) Juan Wang et al.   Molecular Therapy-Nucleic Acids

Early growth response protein 1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease

(2018) Yan-Lin Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy

(2018) Ying Feng et al.   BIOSCIENCE REPORTS

Pancreas Pathology During the Natural History of Type 1 Diabetes

(2018) Teresa Rodriguez-Calvo et al.   Current Diabetes Reports

Histone demethylase UTX is a therapeutic target for diabetic kidney disease

(2018) Hong Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

miR29b regulates aberrant methylation in In-Vitro diabetic nephropathy model of renal proximal tubular cells

(2018) Piyush Gondaliya et al.   PLoS One

The Use of Targeted Next Generation Sequencing to Explore Candidate Regulators of TGF-β1’s Impact on Kidney Cells

(2018) Bo Wang et al.   Frontiers in Physiology

Functional Role of SUV39H1 in Human Renal Tubular Epithelial Cells Under High-glucose Ambiance

(2017) Jiayi Wang et al.   INFLAMMATION

LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with β-catenin

(2017) Mengsi Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway

(2017) Fei Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-30e targets GLIPR-2 to modulate diabetic nephropathy: in vitro and in vivo experiments

(2017) Dong Zhao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Progressive Renal Disease Established by Renin-Coding Adeno-Associated Virus–Driven Hypertension in Diverse Diabetic Models

(2017) Shannon M. Harlan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury

(2017) Li Zhang et al.   KIDNEY INTERNATIONAL

Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice

(2017) Hongyu Zhang et al.   KIDNEY INTERNATIONAL

MicroRNA-326-3p ameliorates high glucose and ox-LDL-IC- induced fibrotic injury in renal mesangial cells by targeting FcγRIII

(2017) Yiting Wang et al.   NEPHROLOGY

The association between methylation levels of targeted genes and albuminuria in patients with early diabetic kidney disease

(2017) Ozgur Aldemir et al.   RENAL FAILURE

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy

(2017) Hong Yi et al.   Cell Death & Disease

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Down-regulation of miR-23a inhibits high glucose-induced EMT and renal fibrogenesis by up-regulation of SnoN

(2017) Haiping Xu et al.   Human Cell

Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy

(2016) Hang Yuan et al.   ANTIOXIDANTS & REDOX SIGNALING

Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population

(2016)   DIABETES CARE

Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum

(2016) William T. Cefalu et al.   DIABETES CARE

Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

(2016) Zhuo Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy

(2016) Shawn S. Badal et al.   Nature Communications

Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy

(2016) Feng Liu et al.   Scientific Reports

Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

(2015) Yangwei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc

(2015) Yinghui Li et al.   CANCER RESEARCH

Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy

(2015) C. Hu et al.   CURRENT MEDICINAL CHEMISTRY

Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat

(2015) Sabbir Khan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy

(2015) K. Bhatt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The function of miR-199a-5p/Klotho regulating TLR4/NF-κB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism

(2015) Can Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes

(2014) Feng Miao et al.   DIABETES

Epigenetic mechanisms in diabetic complications and metabolic memory

(2014) Marpadga A. Reddy et al.   DIABETOLOGIA

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

(2014) H. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

(2014) B. Tampe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetic nephropathy—emerging epigenetic mechanisms

(2014) Mitsuo Kato et al.   Nature Reviews Nephrology

Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease

(2014) Helena M. Kok et al.   Nature Reviews Nephrology

Potential of epigenetic therapies in non-cancerous conditions

(2014) Theresa Mau et al.   Frontiers in Genetics

Glycemic Memories and the Epigenetic Component of Diabetic Nephropathy

(2013) Samuel T. Keating et al.   Current Diabetes Reports

MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice

(2013) Hai-Yong Chen et al.   MOLECULAR THERAPY

AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: A “glycoxidation-centric” point of view

(2013) N.C. Chilelli et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

(2013) Robert V. Intine et al.   Jove-Journal of Visualized Experiments

Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy

(2012) S. Putta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles

(2012) Vidisha Tripathi et al.   MOLECULAR BIOLOGY OF THE CELL

Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes

(2011) Anna Syreeni et al.   DIABETES

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

(2011) Hongting Zheng et al.   DIABETES

DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy

(2011) Carmen Sapienza et al.   Epigenetics

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats

(2011) V. M. Surse et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Epigenetic changes and alteration ofFbn1andCol3A1gene expression under hyperglycaemic and hyperinsulinaemic conditions

(2010) Anil B. Gaikwad et al.   BIOCHEMICAL JOURNAL

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

(2010) Christopher G Bell et al.   BMC Medical Genomics

Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway

(2010) Cairong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic Histone Methylation Modulates Fibrotic Gene Expression

(2010) G. Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10

(2010) Sufyan G. Sayyed et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells

(2009) Shali Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Hypothesis: the “metabolic memory”, the new challenge of diabetes

(2009) Antonio Ceriello   DIABETES RESEARCH AND CLINICAL PRACTICE

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-κB

(2009) Jane Chiu et al.   NUTRITION

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy

(2008) Y. Qian et al.   DIABETES

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

(2008) Louisa M. Villeneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY