Histone demethylase UTX is a therapeutic target for diabetic kidney disease

Update of pathophysiology and management of diabetic kidney disease

(2018) Yi-Chih Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease

(2017) Syamantak Majumder et al.   JOURNAL OF CLINICAL INVESTIGATION

ELABELA and an ELABELA Fragment Protect against AKI

(2017) Hong Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

(2017) Yu Zhang et al.   Nature Communications

Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy

(2017) Fengjuan Tang et al.   Drug Design Development and Therapy

RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor

(2017) Amitabh Das et al.   Scientific Reports

Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin

(2016) HIKARU WATARAI et al.   ANTICANCER RESEARCH

Emerging therapeutics for the treatment of diabetic nephropathy

(2016) Jehrod Brenneman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage

(2016) Samy L. Habib et al.   CELL CYCLE

The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs

(2016) Cristian Doñas et al.   JOURNAL OF AUTOIMMUNITY

UTX demethylase activity is required for satellite cell–mediated muscle regeneration

(2016) Hervé Faralli et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of DNA damage responses in p53 biology

(2015) Daniel Speidel   ARCHIVES OF TOXICOLOGY

Apelin protects against acute renal injury by inhibiting TGF-β1

(2015) Hong Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology

(2015) David Grundy   JOURNAL OF PHYSIOLOGY-LONDON

Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis

(2015) R. Mohamed et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammatory Cytokines in Diabetic Nephropathy

(2015) Javier Donate-Correa et al.   Journal of Diabetes Research

MPHOSPH1: A Potential Therapeutic Target for Hepatocellular Carcinoma

(2014) X. Liu et al.   CANCER RESEARCH

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

(2014) R. Roset et al.   GENES & DEVELOPMENT

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

(2014) Yoshiro Maezawa et al.   Journal of Diabetes Investigation

DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding

(2013) Y Ding et al.   INTERNATIONAL JOURNAL OF OBESITY

Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse

(2013) Hong Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

(2013) Kadir C. Akdemir et al.   NUCLEIC ACIDS RESEARCH

Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in Response to DNA Damage

(2013) Chengwan Zhang et al.   PLoS One

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Inflammation and the pathogenesis of diabetic nephropathy

(2012) Jun Wada et al.   CLINICAL SCIENCE

Inflammation in Diabetic Nephropathy

(2012) Andy K. H. Lim et al.   MEDIATORS OF INFLAMMATION

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

(2012) G. G. Welstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative DNA damage and obesity in type 2 diabetes mellitus

(2011) Hayder A Al-Aubaidy et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice

(2011) Hong Chen et al.   PEPTIDES

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE