circLRP6 regulates high glucose‐induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells

The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

(2019) Rui Yang et al.   Molecular Cancer

CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis

(2018) Qian Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway

(2018) Zhiqiang Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Knockdown of TLR4 attenuates high glucose-induced podocyte injury via the NALP3/ASC/Caspase-1 signaling pathway

(2018) Yang Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-β1

(2018) Wei Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Astilbin Inhibits High Glucose-Induced Inflammation and Extracellular Matrix Accumulation by Suppressing the TLR4/MyD88/NF-κB Pathway in Rat Glomerular Mesangial Cells

(2018) Fang Chen et al.   Frontiers in Pharmacology

Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathway

(2016) Ying Shao et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway

(2016) Xiaoqian Ji et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

(2015) H. Hirata et al.   CANCER RESEARCH

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

(2015) A. D. McClelland et al.   CLINICAL SCIENCE

MiR-135a promotes renal fibrosis in diabetic nephropathy by regulating TRPC1

(2014) Feng He et al.   DIABETOLOGIA

Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1

(2014) Le Zhang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Thrombomodulin's lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling

(2013) Christine Herzog et al.   CARDIOVASCULAR RESEARCH

Astilbin protects diabetic rat heart against ischemia–reperfusion injury via blockade of HMGB1-dependent NF-κB signaling pathway

(2013) Huiling Diao et al.   FOOD AND CHEMICAL TOXICOLOGY

The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy

(2013) Miao Lin et al.   KIDNEY INTERNATIONAL

High-Mobility Group Box 1 Inhibits Gastric Ulcer Healing through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products

(2013) Yuji Nadatani et al.   PLoS One

Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells

(2012) Shiyo Muratsu-Ikeda et al.   PLoS One

Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide

(2011) P. Yuan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Relationship between Oxidative Stress and Inflammatory Cytokines in Diabetic Nephropathy

(2010) Ahmed A. Elmarakby et al.   Cardiovascular Therapeutics

HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells

(2010) Zheng-Gang Luan et al.   IMMUNOBIOLOGY

Loss of MicroRNA-192 Promotes Fibrogenesis in Diabetic Nephropathy

(2010) A. Krupa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidative stress in early diabetic nephropathy: fueling the fire

(2010) Dhruv K. Singh et al.   Nature Reviews Endocrinology

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY