Evolving therapies for liver fibrosis

1024 In Vivo Efficacy of C12-200 Lipid-Like SiRNA Carriers to Inhibit Hepatic Fibrosis

(2015) Carolina Jiménez Calvente et al.   GASTROENTEROLOGY

Stem cell therapies for liver failure and cirrhosis

(2013) Zheng Zhang et al.   JOURNAL OF HEPATOLOGY

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis

(2012) Imre Noth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of Disease Progression in NASH

(2012) Brittany N. Bohinc et al.   Clinics in Liver Disease

Fibroproliferative Disorders and Their Mechanobiology

(2012) Chenyu Huang et al.   CONNECTIVE TISSUE RESEARCH

Th17 Cells Regulate Liver Fibrosis by Targeting Multiple Cell Types: Many Birds With One Stone

(2012) Bin Gao et al.   GASTROENTEROLOGY

Noninvasive Methods to Assess Liver Disease in Patients With Hepatitis B or C

(2012) Laurent Castera   GASTROENTEROLOGY

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

MicroRNAs in Liver Disease

(2012) Xin Wei Wang et al.   GASTROENTEROLOGY

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Hepatic vein arrival time as assessed by contrast-enhanced ultrasonography is useful for the assessment of portal hypertension in compensated cirrhosis

(2012) Moon Young Kim et al.   HEPATOLOGY

Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: A pilot study

(2012) Giovanna Ferraioli et al.   HEPATOLOGY

AASLD Abstracts

(2012)   HEPATOLOGY

Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice

(2012) Hacer Sahin et al.   HEPATOLOGY

A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice

(2012) Juan E. Puche et al.   HEPATOLOGY

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

α11β1 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: Evidence for integrin-coordinated collagen proteolysis

(2012) Malgorzata M. Barczyk et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

(2012) Sabine Klein et al.   JOURNAL OF HEPATOLOGY

Anti-fibrotic therapy: Lost in translation?

(2012) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Microparticles: Modulators and biomarkers of liver disease

(2012) Miroslaw Kornek et al.   JOURNAL OF HEPATOLOGY

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Beneficial effects of candesartan, an angiotensin-blocking agent, on compensated alcoholic liver fibrosis - A randomized open-label controlled study

(2012) Moon Young Kim et al.   LIVER INTERNATIONAL

Treatment of Idiopathic Pulmonary Fibrosis with Losartan: A Pilot Project

(2012) Marisa Couluris et al.   LUNG

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

(2012) Gabriel A Kwong et al.   NATURE BIOTECHNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges

(2012) Filomena de Nigris et al.   Recent Patents on Anti-Cancer Drug Discovery

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

(2012) Feng Fang et al.   ARTHRITIS RESEARCH & THERAPY

The Role of Chemokines in Acute Liver Injury

(2012) Yedidya Saiman et al.   Frontiers in Physiology

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of integrins in fibrosing liver diseases

(2011) Eleonora Patsenker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Therapeutic targets in liver fibrosis

(2011) Jonathan A. Fallowfield   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obesity, diabetes mellitus, and liver fibrosis

(2011) Dian J. Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Innate immunity in alcoholic liver disease

(2011) Bin Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppression of hepatic stellate cell activation by microRNA-29b

(2011) Yumiko Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll-like receptor-4 antagonist eritoran tetrasodium for severe sepsis

(2011) Mark Tidswell et al.   Expert Review of Anti-Infective Therapy

Accelerated and Progressive and Lethal Liver Fibrosis in Mice That Lack Interleukin (IL)-10, IL-12p40, and IL-13Rα2

(2011) Margaret M. Mentink–Kane et al.   GASTROENTEROLOGY

Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

(2011) Yury Popov et al.   GASTROENTEROLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Biomarkers of liver fibrosis: What lies beneath the receiver operating characteristic curve?

(2011) Indra Neil Guha et al.   HEPATOLOGY

Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial

(2011) Claudia O. Zein et al.   HEPATOLOGY

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

(2011) Won-Il Jeong et al.   HEPATOLOGY

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

(2011) Dominique Thabut et al.   HEPATOLOGY

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

(2011) Ruchi Bansal et al.   HEPATOLOGY

Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open- label trial

(2011) Dawn M. Torres et al.   HEPATOLOGY

Targeted therapy of liver fibrosis/cirrhosis and its complications

(2011) Klaas Poelstra et al.   JOURNAL OF HEPATOLOGY

The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis

(2011) Tatiana Kisseleva et al.   JOURNAL OF HEPATOLOGY

New horizons for stem cell therapy in liver disease

(2011) Stuart J. Forbes et al.   JOURNAL OF HEPATOLOGY

Targeted Drug Delivery Using Immunoconjugates

(2011) Maria Valentina Pasquetto et al.   JOURNAL OF IMMUNOTHERAPY

Clinical use of CCR5 inhibitors in HIV and beyond

(2011) Bruce L Gilliam et al.   Journal of Translational Medicine

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent

(2011) Marcus R Makowski et al.   NATURE MEDICINE

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families

(2011) Yoshiki Murakami et al.   PLoS One

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis

(2010) Yury Popov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis

(2010) J.S. Duffield et al.   DRUG NEWS & PERSPECTIVES

Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Dead or Alive?

(2010) Yury Popov et al.   GASTROENTEROLOGY

Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis In Vivo

(2010) Joy X. Jiang et al.   GASTROENTEROLOGY

Serum fibrosis markers are associated with liver disease progression in non-responder patients with chronic hepatitis C

(2010) R. J. Fontana et al.   GUT

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Enhanced liver fibrosis test can predict clinical outcomes in patients with chronic liver disease

(2010) J. Parkes et al.   GUT

The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes

(2010) Karlin Raja Karlmark et al.   HEPATOLOGY

Noninvasive assessment of liver fibrosis

(2010) Stella M. Martínez et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Anti-PDGF-B monoclonal antibody reduces liver fibrosis development

(2010) Shinji Ogawa et al.   HEPATOLOGY RESEARCH

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

(2010) Marie-Luise Berres et al.   JOURNAL OF CLINICAL INVESTIGATION

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?

(2010) Dominique Thabut et al.   JOURNAL OF HEPATOLOGY

A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

(2010) Henning W. Zimmermann et al.   PLoS One

Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis

(2010) C. Stockmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Death and Fibrogenesis

(2010) Wajahat Mehal et al.   SEMINARS IN LIVER DISEASE

Chemokines in Liver Inflammation and Fibrosis

(2010) Hermann Wasmuth et al.   SEMINARS IN LIVER DISEASE

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

(2009) Jordi Colmenero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanical Stretch Regulates the Expression of Matrix Metalloproteinase in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

(2009) Ping Wang et al.   CONNECTIVE TISSUE RESEARCH

Regulation of Matrix Synthesis, Remodeling and Accumulation in Glomerulosclerosis

(2009) Ambra Pozzi et al.   CURRENT PHARMACEUTICAL DESIGN

Pirfenidone in idiopathic pulmonary fibrosis

(2009) H. Taniguchi et al.   EUROPEAN RESPIRATORY JOURNAL

Antifibrotic Effects of CXCL9 and Its Receptor CXCR3 in Livers of Mice and Humans

(2009) Hermann E. Wasmuth et al.   GASTROENTEROLOGY

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY

Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection

(2009) John McHutchison et al.   GASTROENTEROLOGY

Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis

(2009) Eleonora Patsenker et al.   HEPATOLOGY

Portal fibroblasts: Underappreciated mediators of biliary fibrosis

(2009) Jonathan A. Dranoff et al.   HEPATOLOGY

Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies

(2009) Yury Popov et al.   HEPATOLOGY

Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

(2009) Vlad Ratziu et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis

(2009) Mirko Moreno Zaldivar et al.   HEPATOLOGY

CCR1 and CCR5 promote hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine signaling contributes to ethanol-induced fatty liver in mice

(2009) Zhongsheng Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

(2009) Joy X. Jiang et al.   JOURNAL OF HEPATOLOGY

Effect of Treatment of Hepatic Histopathology in Children and Adolescents With Autoimmune Hepatitis

(2009) Alexandre Rodrigues Ferreira et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

Mononuclear cells in liver fibrosis

(2009) Fabio Marra et al.   Seminars in Immunopathology

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

(2008) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

(2008) Erwin Gäbele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diagnosis and Quantitation of Fibrosis

(2008) Diarmuid S. Manning et al.   GASTROENTEROLOGY

Magnetic Resonance Elastography for the Noninvasive Staging of Liver Fibrosis

(2008) Laurent Huwart et al.   GASTROENTEROLOGY

Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans

(2008) Youngmi Jung et al.   GASTROENTEROLOGY

Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression

(2008) Eleonora Patsenker et al.   GASTROENTEROLOGY

Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis

(2008) Guruprasad P. Aithal et al.   GASTROENTEROLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay

(2008) Marlyn J. Mayo et al.   HEPATOLOGY

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

(2008) Ogyi Park et al.   HEPATOLOGY

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

(2008) Alessia Omenetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

(2008) Yury Popov et al.   JOURNAL OF HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose Peginterferon

(2008) Adrian M. Di Bisceglie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE