An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

(2013) Yulia A. Nevzorova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ–Induced Signaling in Human Monocytes

(2013) Marianne R. Spalinger et al.   GASTROENTEROLOGY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Discovery of novel src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma

(2013) Wei-Tien Tai et al.   HEPATOLOGY

Hepatocyte-specificPtpn6deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ

(2013) Elaine Xu et al.   HEPATOLOGY

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases

(2013) Tamiko R. Katsumoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein Tyrosine Phosphatase with Proline-Glutamine-Serine-Threonine-Rich Motifs Negatively Regulates TLR-Triggered Innate Responses by Selectively Inhibiting I B Kinase  /NF- B Activation

(2013) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance

(2012) E. Xu et al.   DIABETES

microRNA are Central Players in Anti- and Profibrotic Gene Regulation during Liver Fibrosis

(2012) Andrea Noetel et al.   Frontiers in Physiology

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

MicroRNA in TLR signaling and endotoxin tolerance

(2011) Md A Nahid et al.   Cellular & Molecular Immunology

Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice

(2011) Xin Zeng et al.   HEPATOLOGY

Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture

(2011) Yixin Chen et al.   HEPATOLOGY

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

(2011) Mohammad R Ebrahimkhani et al.   NATURE MEDICINE

MicroRNAs and STAT interplay

(2011) Gary Kohanbash et al.   SEMINARS IN CANCER BIOLOGY

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

Hepatocyte Nuclear Factor 4  Suppresses the Development of Hepatocellular Carcinoma

(2010) B.-F. Ning et al.   CANCER RESEARCH

The role of intestinal endotoxin in liver injury: A long and evolving history

(2010) James P. Nolan   HEPATOLOGY

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

MicroRNA control of signal transduction

(2010) Masafumi Inui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatic nuclear factor 1-α: inflammation, genetics, and atherosclerosis

(2009) Angela D Armendariz et al.   CURRENT OPINION IN LIPIDOLOGY

Hepatocyte nuclear factor 4  attenuates hepatic fibrosis in rats

(2009) H.-Y. Yue et al.   GUT

Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats

(2009) Wei Zhong et al.   HEPATOLOGY

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

(2009) Marianna Hösel et al.   HEPATOLOGY

Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation

(2009) Yajaira Suárez et al.   JOURNAL OF IMMUNOLOGY

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Pathways in Liver Homeostasis and Liver Injury

(2008) Frank Tacke et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS