Cardiolipin, Mitochondria, and Neurological Disease

Uncovering pathophysiological changes in frontotemporal dementia using serum lipids

(2020) Katherine Phan et al.   Scientific Reports

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

(2020) Yevgeniya A. Abramzon et al.   Frontiers in Neuroscience

AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome

(2020) Suya Wang et al.   CIRCULATION RESEARCH

Development of disease-modifying drugs for frontotemporal dementia spectrum disorders

(2020) Francesco Panza et al.   Nature Reviews Neurology

Phospholipid Acyl Chain Diversity Controls the Tissue-Specific Assembly of Mitochondrial Cardiolipins

(2020) Gregor Oemer et al.   Cell Reports

Cardiolipin remodeling in Barth syndrome and other hereditary cardiomyopathies

(2020) Edoardo Bertero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial damage & lipid signaling in traumatic brain injury

(2020) Andrew M. Lamade et al.   EXPERIMENTAL NEUROLOGY

Cardiolipin-deficient cells have decreased levels of the iron-sulfur biogenesis protein frataxin

(2020) Yiran Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid ebb and flow makes mitochondria go

(2020) Michelle Grace Acoba et al.   JOURNAL OF CELL BIOLOGY

Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis

(2020) Richard G. Lee et al.   JOURNAL OF CELL SCIENCE

Mitochondrial protein interaction landscape of SS-31

(2020) Juan D. Chavez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter

(2020) Sagnika Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes

(2020) Ruchika Anand et al.   Life Science Alliance

The mitochondrial ADP/ATP carrier exists and functions as a monomer

(2020) Edmund R.S. Kunji et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure of the dimeric ATP synthase from bovine mitochondria

(2020) Tobias E. Spikes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiolipin, conformation, and respiratory complex-dependent oligomerization of the major mitochondrial ADP/ATP carrier in yeast

(2020) N. Senoo et al.   Science Advances

Function-related asymmetry of the specific cardiolipin binding sites on the mitochondrial ADP/ATP carrier

(2020) Xiaoting Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cardiolipin-dependent mitophagy guides outcome after traumatic brain injury

(2019) Honglu Chao et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular cardiolipin regulates select immune functions of microglia and microglia-like cells

(2019) Caitlin B. Pointer et al.   BRAIN RESEARCH BULLETIN

Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases

(2019) Chengjie Song et al.   AGING CELL

Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice

(2019) S. Lores-Arnaiz et al.   EXPERIMENTAL GERONTOLOGY

Assembly of the complexes of oxidative phosphorylation triggers the remodeling of cardiolipin

(2019) Yang Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipidomic Alterations in the Mitochondria of Aged Parkin Null Mice Relevant to Autophagy

(2019) Angel Gaudioso et al.   Frontiers in Neuroscience

Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes

(2019) Stephanie Ghio et al.   ACS Chemical Neuroscience

Detection of brain specific cardiolipins in plasma after experimental pediatric head injury

(2019) Tamil S. Anthonymuthu et al.   EXPERIMENTAL NEUROLOGY

A Bayesian Analysis to Determine the Prevalence of Barth Syndrome in the Pediatric Population

(2019) Paighton C. Miller et al.   JOURNAL OF PEDIATRICS

Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis

(2019) Adriano Britto Chaves-Filho et al.   Scientific Reports

Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals

(2019) Takaoki Kasahara et al.   FASEB JOURNAL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

(2018) Elahu G. Sustarsic et al.   Cell Metabolism

How cardiolipin peroxidation alters the properties of the inner mitochondrial membrane?

(2018) Marjut Vähäheikkilä et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26–Mic27 Antagonism and Cardiolipin

(2018) Heike Rampelt et al.   JOURNAL OF MOLECULAR BIOLOGY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular structural diversity of mitochondrial cardiolipins

(2018) Gregor Oemer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

(2018) Tammy Ryan et al.   Nature Communications

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease

(2018) Timothy J. Tracey et al.   Frontiers in Molecular Neuroscience

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Ying Cheng et al.   Frontiers in Neuroscience

The Effects of PPAR Stimulation on Cardiac Metabolic Pathways in Barth Syndrome Mice

(2018) Caitlin Schafer et al.   Frontiers in Pharmacology

Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice

(2018) Laura K. Cole et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome

(2018) Silveli Suzuki-Hatano et al.   HUMAN GENE THERAPY

Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Vera F. Monteiro-Cardoso et al.   JOURNAL OF ALZHEIMERS DISEASE

SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury

(2018) Yihao Zhu et al.   Oxidative Medicine and Cellular Longevity

Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target

(2018) Mariona Jové et al.   Redox Biology

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

(2017) Gao-Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin promotes electron transport between ubiquinone and complex I to rescuePINK1deficiency

(2017) Melissa Vos et al.   JOURNAL OF CELL BIOLOGY

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

(2017) Milena Vukotic et al.   MOLECULAR CELL

Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion

(2017) Aaron F. Phillips et al.   MOLECULAR CELL

Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin

(2017) Tadato Ban et al.   NATURE CELL BIOLOGY

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50

(2017) Ketan Malhotra et al.   Science Advances

Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice

(2016) Z. Zhao et al.   BLOOD

Mitochondrial contact site and cristae organizing system

(2016) Martin van der Laan et al.   CURRENT OPINION IN CELL BIOLOGY

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

(2016) Paul S. Baxter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury

(2016) Louis J. Sparvero et al.   JOURNAL OF NEUROCHEMISTRY

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

(2016) Ian T.S. Coyle-Gilchrist et al.   NEUROLOGY

Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases

(2016) Anna L. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of α-synuclein with biomembranes in Parkinson's disease —role of cardiolipin

(2016) Stephanie Ghio et al.   PROGRESS IN LIPID RESEARCH

LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease

(2015) Y. Y. Tyurina et al.   FREE RADICAL RESEARCH

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

(2015) Natalia Stepanyants et al.   MOLECULAR BIOLOGY OF THE CELL

LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons

(2014) Charleen T Chu et al.   Autophagy

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

The role of lipid peroxidation in neurological disorders

(2014) Mototada Shichiri   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Barth syndrome without tetralinoleoyl cardiolipin deficiency: a possible ameliorated phenotype

(2014) Ann Bowron et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Clinical laboratory studies in Barth Syndrome

(2014) Hilary J. Vernon et al.   MOLECULAR GENETICS AND METABOLISM

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

TRIAP1/PRELI Complexes Prevent Apoptosis by Mediating Intramitochondrial Transport of Phosphatidic Acid

(2013) Christoph Potting et al.   Cell Metabolism

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin

(2013) Giuseppe Petrosillo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial lipid transport at a glance

(2013) M. Scharwey et al.   JOURNAL OF CELL SCIENCE

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Lack of the Mitochondrial Protein Acylglycerol Kinase Causes Sengers Syndrome

(2012) Johannes A. Mayr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The stability and activity of respiratory Complex II is cardiolipin-dependent

(2012) Christine T. Schwall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Loss of Cardiolipin Leads to Perturbation of Mitochondrial and Cellular Iron Homeostasis

(2012) Vinay A. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness

(2012) Saskia B Wortmann et al.   NATURE GENETICS

Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis

(2011) Ji Zhang et al.   Cell Metabolism

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

(2010) Devrim Acehan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

(2010) Teuntje M. J. C. Andriessen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cardiolipin and mitochondrial carriers

(2009) Martin Klingenberg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of cardiolipin in the structural organization of mitochondrial membranes

(2009) Michael Schlame et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial Cardiolipin Involved in Outer-Membrane Protein Biogenesis: Implications for Barth Syndrome

(2009) Natalia Gebert et al.   CURRENT BIOLOGY

Peroxidase Mechanism of Lipid-dependent Cross-linking of Synuclein with Cytochromec

(2009) Hülya Bayır et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane

(2008) Steven M. Claypool et al.   JOURNAL OF CELL BIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dysfunction in rat brain with agingInvolvement of complex I, reactive oxygen species and cardiolipin

(2008) G PETROSILLO et al.   NEUROCHEMISTRY INTERNATIONAL

Bloodspot Assay Using HPLC-Tandem Mass Spectrometry for Detection of Barth Syndrome

(2007) W. Kulik et al.   CLINICAL CHEMISTRY