Development of disease-modifying drugs for frontotemporal dementia spectrum disorders
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Title
Development of disease-modifying drugs for frontotemporal dementia spectrum disorders
Authors
Keywords
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Journal
Nature Reviews Neurology
Volume 16, Issue 4, Pages 213-228
Publisher
Springer Science and Business Media LLC
Online
2020-03-23
DOI
10.1038/s41582-020-0330-x
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Note: Only part of the references are listed.- A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
- (2019) Francesco Panza et al. Nature Reviews Neurology
- Toward a Glutamate Hypothesis of Frontotemporal Dementia
- (2019) Alberto Benussi et al. Frontiers in Neuroscience
- Disease-modifying therapies for tauopathies: agents in the pipeline
- (2019) Francesco Panza et al. Expert Review of Neurotherapeutics
- An update on genetic frontotemporal dementia
- (2019) Caroline V. Greaves et al. JOURNAL OF NEUROLOGY
- Precision Medicine for Frontotemporal Dementia
- (2019) Mu-N Liu et al. Frontiers in Psychiatry
- Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial
- (2019) Adam L Boxer et al. LANCET NEUROLOGY
- Neuroinflammation in frontotemporal dementia
- (2019) Fiona Bright et al. Nature Reviews Neurology
- Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
- (2019) Raygene Martier et al. Molecular Therapy-Nucleic Acids
- Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
- (2019) Thomas J. Hedl et al. Frontiers in Neuroscience
- Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome
- (2019) Richard M. Tsai et al. JAMA Neurology
- Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases
- (2018) Inga Zerr et al. Alzheimers & Dementia
- NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
- (2018) Clifford R. Jack et al. Alzheimers & Dementia
- Autoimmunity and Frontotemporal Dementia
- (2018) Antonella Alberici et al. Current Alzheimer Research
- Pharmacotherapy for the treatment of depression in patients with alzheimer’s disease: a treatment-resistant depressive disorder
- (2018) Madia Lozupone et al. EXPERT OPINION ON PHARMACOTHERAPY
- Progranulin as a therapeutic target for dementia
- (2018) Daniela Galimberti et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Plasma tau is increased in frontotemporal dementia
- (2018) Martha S Foiani et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders
- (2018) Katrin Augustin et al. LANCET NEUROLOGY
- ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
- (2018) Martina de Majo et al. NEUROBIOLOGY OF AGING
- Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum
- (2018) Lieke H.H. Meeter et al. NEUROLOGY
- A language-based sum score for the course and therapeutic intervention in primary progressive aphasia
- (2018) Elisa Semler et al. Alzheimers Research & Therapy
- CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?
- (2018) Peter Körtvelyessy et al. Frontiers in Neurology
- Memantine in Behavioral Variant Frontotemporal Dementia: Negative Results
- (2018) Martine Vercelletto et al. JOURNAL OF ALZHEIMERS DISEASE
- N-terminal Truncation of Microtubule Associated Protein Tau Dysregulates its Cellular Localization
- (2018) Kristina Paholikova et al. JOURNAL OF ALZHEIMERS DISEASE
- Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory
- (2018) Peter A. Ljubenkov et al. Annals of Clinical and Translational Neurology
- Therapeutic trial design for frontotemporal dementia and related disorders
- (2018) Philippe Desmarais et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Review: Neuropathology of non-tau frontotemporal lobar degeneration
- (2018) M. Neumann et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Nutritional interventions and cognitive-related outcomes in patients with late-life cognitive disorders: A systematic review
- (2018) Vincenzo Solfrizzi et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease
- (2018) Petr Novak et al. Alzheimers Research & Therapy
- Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials
- (2018) Adam M Staffaroni et al. BRAIN
- New routes in frontotemporal dementia drug discovery
- (2017) Laura De Conti et al. Expert Opinion on Drug Discovery
- Pharmacological Management of Psychiatric Symptoms in Frontotemporal Dementia: A Systematic Review
- (2017) Massimiliano Buoli et al. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
- Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology
- (2017) John T O’Brien et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial
- (2017) Petr Novak et al. LANCET NEUROLOGY
- Anti-tau vaccine in Alzheimer's disease: a tentative step
- (2017) Francesco Panza et al. LANCET NEUROLOGY
- Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
- (2017) Nicholas B. Hastings et al. Molecular Neurodegeneration
- Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
- (2017) Günter U. Höglinger et al. MOVEMENT DISORDERS
- A clinicopathological approach to the diagnosis of dementia
- (2017) Fanny M. Elahi et al. Nature Reviews Neurology
- TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
- (2017) Ian R. Mackenzie et al. NEURON
- Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
- (2017) Sarah L. DeVos et al. Science Translational Medicine
- A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies
- (2017) Miranda E. Orr et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target
- (2017) B. Borroni et al. Scientific Reports
- Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria
- (2017) Michael J. Strong et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Therapeutic strategies for the treatment of tauopathies: Hopes and challenges
- (2016) Mansi R. Khanna et al. Alzheimers & Dementia
- Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium
- (2016) Davide Seripa et al. Expert Review of Neurotherapeutics
- Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy
- (2016) Francesco Panza et al. Immunotherapy
- Bipolar Disorder and Frontotemporal Dementia: An Intriguing Association
- (2016) Apostolos Papazacharias et al. JOURNAL OF ALZHEIMERS DISEASE
- Neurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: an update
- (2016) Patrick Oeckl et al. JOURNAL OF NEUROCHEMISTRY
- Therapy and clinical trials in frontotemporal dementia: past, present, and future
- (2016) Richard M. Tsai et al. JOURNAL OF NEUROCHEMISTRY
- Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
- (2016) Serge Gauthier et al. LANCET
- Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
- (2016) Christopher J. Holler et al. Molecular Neurodegeneration
- Agomelatine Improves Apathy in Frontotemporal Dementia
- (2016) Ilaria Callegari et al. Neurodegenerative Diseases
- Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes
- (2016) Ian T.S. Coyle-Gilchrist et al. NEUROLOGY
- Tauopathies as clinicopathological entities
- (2016) David J. Irwin PARKINSONISM & RELATED DISORDERS
- Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts
- (2016) N. J. Kramer et al. SCIENCE
- Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
- (2016) Katannya Kapeli et al. Nature Communications
- CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
- (2016) Kelly L. Williams et al. Nature Communications
- Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium
- (2016) Davide Seripa et al. Expert Review of Neurotherapeutics
- Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration
- (2016) Ito Kawakami et al. Acta Neuropathologica Communications
- Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
- (2015) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease
- (2015) Cyril Pottier et al. ACTA NEUROPATHOLOGICA
- Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists
- (2015) S. Sakura Minami et al. BIOCHEMICAL PHARMACOLOGY
- Cerebrospinal fluid tau and amyloid-β1-42in patients with dementia
- (2015) Tobias Skillbäck et al. BRAIN
- Improving response inhibition systems in frontotemporal dementia with citalopram
- (2015) Laura E. Hughes et al. BRAIN
- Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus
- (2015) Jiaxin Hu et al. CHEMISTRY & BIOLOGY
- Progresses in treating agitation: a major clinical challenge in Alzheimer’s disease
- (2015) Francesco Panza et al. EXPERT OPINION ON PHARMACOTHERAPY
- A Case of Frontotemporal Dementia Presenting With Treatment-Refractory Psychosis and Extreme Violence
- (2015) Manish Kumar Jha et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes
- (2015) N K Magdalinou et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Cerebrospinal fluid Aβ40 is similarly reduced in patients with Frontotemporal Lobar Degeneration and Alzheimer's Disease
- (2015) Inês Baldeiras et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Frontotemporal dementia
- (2015) Jee Bang et al. LANCET
- Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
- (2015) Sang-Won Min et al. NATURE MEDICINE
- Human secreted tau increases amyloid-beta production
- (2015) Jessica Bright et al. NEUROBIOLOGY OF AGING
- Treatment with a Global Methyltransferase Inhibitor Induces the Intranuclear Aggregation of ALS-Linked FUS Mutant In Vitro
- (2015) Sakiko Fujii et al. NEUROCHEMICAL RESEARCH
- Souvenaid Reduces Behavioral Deficits and Improves Social Cognition Skills in Frontotemporal Dementia: A Proof-of-Concept Study
- (2015) Matteo Pardini et al. Neurodegenerative Diseases
- CSF Neurofilament Light Chain but not FLT3 Ligand Discriminates Parkinsonian Disorders
- (2015) Megan K. Herbert et al. Frontiers in Neurology
- Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis
- (2015) Hanne Struyfs et al. Frontiers in Neurology
- The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy
- (2015) Robert Siman et al. PLoS One
- Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine
- (2014) David J. Irwin et al. ACTA NEUROPATHOLOGICA
- A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
- (2014) Sylvie Bannwarth et al. BRAIN
- Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
- (2014) G. Elif Karagöz et al. CELL
- Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target
- (2014) Brandon B. Holmes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Does CSF p-tau181 help to discriminate Alzheimer’s disease from other dementias and mild cognitive impairment? A meta-analysis of the literature
- (2014) Wei Tang et al. JOURNAL OF NEURAL TRANSMISSION
- Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies
- (2014) Chun-ling Dai et al. JOURNAL OF NEURAL TRANSMISSION
- Assessment of CSF Aβ42 as an aid to discriminating Alzheimer's disease from other dementias and mild cognitive impairment: A meta-analysis of 50 studies
- (2014) Wei Tang et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial
- (2014) Adam L Boxer et al. LANCET NEUROLOGY
- A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy
- (2014) Eduardo Tolosa et al. MOVEMENT DISORDERS
- Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial
- (2014) Günter U. Höglinger et al. MOVEMENT DISORDERS
- Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation
- (2014) A. Alberici et al. NEUROLOGICAL SCIENCES
- Oxytocin for frontotemporal dementia: A randomized dose-finding study of safety and tolerability
- (2014) E. C. Finger et al. NEUROLOGY
- First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
- (2014) Eva Kontsekova et al. Alzheimers Research & Therapy
- Csf p-tau181/tau ratio as biomarker for TDP pathology in frontotemporal dementia
- (2014) Barbara Borroni et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies
- (2014) Reeteka Sud et al. Molecular Therapy-Nucleic Acids
- Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
- (2014) Yvonne S Davidson et al. Acta Neuropathologica Communications
- Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
- (2013) Kohji Mori et al. ACTA NEUROPATHOLOGICA
- Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS
- (2013) Tania F. Gendron et al. ACTA NEUROPATHOLOGICA
- A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment
- (2013) Bruce H. Morimoto et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
- (2013) Wing C. Lee et al. HUMAN MOLECULAR GENETICS
- Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders
- (2013) J. Janssens et al. HUMAN MOLECULAR GENETICS
- TARDBPandFUSMutations Associated with Amyotrophic Lateral Sclerosis: Summary and Update
- (2013) Serena Lattante et al. HUMAN MUTATION
- Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial
- (2013) Adam L Boxer et al. LANCET NEUROLOGY
- Tau pathology and neurodegeneration
- (2013) Maria Grazia Spillantini et al. LANCET NEUROLOGY
- NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport
- (2013) Yan Jouroukhin et al. NEUROBIOLOGY OF DISEASE
- Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP
- (2013) W. T. Hu et al. NEUROLOGY
- Criteria for the diagnosis of corticobasal degeneration
- (2013) M. J. Armstrong et al. NEUROLOGY
- Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
- (2013) Peter E.A. Ash et al. NEURON
- RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
- (2013) Christopher J. Donnelly et al. NEURON
- Effects of Davunetide on N-acetylaspartate and Choline in Dorsolateral Prefrontal Cortex in Patients with Schizophrenia
- (2013) L Fredrik Jarskog et al. NEUROPSYCHOPHARMACOLOGY
- Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
- (2013) Sefika Ozcelik et al. PLoS One
- Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice
- (2013) Peter Borghgraef et al. PLoS One
- RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
- (2013) T. Zu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
- (2013) C. Lagier-Tourenne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
- (2013) K. Mori et al. SCIENCE
- Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
- (2013) D. Sareen et al. Science Translational Medicine
- Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
- (2013) Amy M Pooler et al. Alzheimers Research & Therapy
- Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
- (2013) Takashi Nonaka et al. Cell Reports
- Development and Validation of Pedigree Classification Criteria for Frontotemporal Lobar Degeneration
- (2013) Elisabeth M. Wood et al. JAMA Neurology
- Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations
- (2012) Manuela Neumann et al. ACTA NEUROPATHOLOGICA
- The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)
- (2012) Adam L. Boxer et al. Alzheimers & Dementia
- Degradation of tau protein by autophagy and proteasomal pathways: Figure 1
- (2012) Yipeng Wang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development
- (2012) Shiro Soga et al. CURRENT PHARMACEUTICAL DESIGN
- A Pan-European Study of theC9orf72Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats
- (2012) Julie van der Zee et al. HUMAN MUTATION
- Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype
- (2012) Matthis Synofzik et al. NEUROBIOLOGY OF AGING
- C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts
- (2012) C. Dobson-Stone et al. NEUROLOGY
- Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies
- (2011) Zeshan Ahmed et al. ACTA NEUROPATHOLOGICA
- Transportin1: a marker of FTLD-FUS
- (2011) Jack Brelstaff et al. ACTA NEUROPATHOLOGICA
- Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?
- (2011) Heiko Braak et al. ACTA NEUROPATHOLOGICA
- Neuropathological background of phenotypical variability in frontotemporal dementia
- (2011) Keith A. Josephs et al. ACTA NEUROPATHOLOGICA
- A harmonized classification system for FTLD-TDP pathology
- (2011) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- Serotonergic Function and Treatment of Behavioral and Psychological Symptoms of Frontotemporal Dementia
- (2011) Nathan Herrmann et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- The effects of oxytocin on social cognition and behaviour in frontotemporal dementia
- (2011) Sarah Jesso et al. BRAIN
- FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
- (2011) Manuela Neumann et al. BRAIN
- Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
- (2011) J. D. Rohrer et al. BRAIN
- Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
- (2011) Katya Rascovsky et al. BRAIN
- Tau and p-tau as CSF biomarkers in dementia: a meta-analysis
- (2011) Argonde C. van Harten et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Frontotemporal Dementia Caused by CHMP2B Mutations
- (2011) A. M. Isaacs et al. Current Alzheimer Research
- Phenotypic signatures of genetic frontotemporal dementia
- (2011) Jonathan D. Rohrer et al. CURRENT OPINION IN NEUROLOGY
- Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription
- (2011) Basar Cenik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
- (2011) A. Capell et al. JOURNAL OF NEUROSCIENCE
- Classification of primary progressive aphasia and its variants
- (2011) M. L. Gorno-Tempini et al. NEUROLOGY
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking
- (2011) Yanqiu Zheng et al. PLoS One
- Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia
- (2011) Daniel C. Javitt et al. SCHIZOPHRENIA RESEARCH
- The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
- (2011) W. Tang et al. SCIENCE
- World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Alzheimer's disease and other dementias
- (2011) Ralf Ihl et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
- (2010) Brian C. Kraemer et al. ACTA NEUROPATHOLOGICA
- FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
- (2010) Hazel Urwin et al. ACTA NEUROPATHOLOGICA
- Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis
- (2010) Iuga Liepelt et al. Alzheimers & Dementia
- Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia
- (2010) J. Yan et al. NEUROLOGY
- Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
- (2010) Fenghua Hu et al. NEURON
- FUS pathology in basophilic inclusion body disease
- (2009) David G. Munoz et al. ACTA NEUROPATHOLOGICA
- Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
- (2009) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- TARDBPmutations in motoneuron disease with frontotemporal lobar degeneration
- (2009) Lina Benajiba et al. ANNALS OF NEUROLOGY
- Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
- (2009) N. Finch et al. BRAIN
- A new subtype of frontotemporal lobar degeneration with FUS pathology
- (2009) M. Neumann et al. BRAIN
- Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease
- (2009) F. Liu et al. BRAIN
- Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models
- (2009) Makiko Yamashita et al. FEBS LETTERS
- Stimulant Treatment of Frontotemporal Dementia in 8 Patients
- (2009) Edward D. Huey et al. JOURNAL OF CLINICAL PSYCHIATRY
- Behavioural abnormalities associated with rapid deterioration of language functions in semantic dementia respond to sertraline
- (2009) C I Prodan et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- "Frontotemporoparietal" dementia: Clinical phenotype associated with the c.709-1G>A PGRN mutation
- (2009) F. Moreno et al. NEUROLOGY
- The heritability and genetics of frontotemporal lobar degeneration
- (2009) J. D. Rohrer et al. NEUROLOGY
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- Frontotemporal dementia and related disorders: Deciphering the enigma
- (2008) Keith A. Josephs ANNALS OF NEUROLOGY
- The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†
- (2008) Sadasivam Jeganathan et al. BIOCHEMISTRY
- Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions
- (2008) Ian R. A. Mackenzie et al. BRAIN
- Galantamine in Frontotemporal Dementia and Primary Progressive Aphasia
- (2008) A. Kertesz et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
- (2008) Philip Van Damme et al. JOURNAL OF CELL BIOLOGY
- A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease
- (2008) Y. Matsuoka et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration
- (2008) R. Ghidoni et al. NEUROLOGY
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