On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease

Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation

(2020) Susan D. Lee et al.   RNA Biology

Structure of an active human histone pre-mRNA 3′-end processing machinery

(2020) Yadong Sun et al.   SCIENCE

FttA is a CPSF73 homologue that terminates transcription in Archaea

(2020) Travis J. Sanders et al.   Nature Microbiology

Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases

(2020) Katarzyna Kaczmarek Michaels et al.   NUCLEIC ACIDS RESEARCH

Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5’-3’ exonuclease

(2020) Xiao-cui Yang et al.   RNA

The Integrator Complex in Transcription and Development

(2020) María Saraí Mendoza-Figueroa et al.   TRENDS IN BIOCHEMICAL SCIENCES

Termination of Transcription by RNA Polymerase II: BOOM!

(2020) Joshua D. Eaton et al.   TRENDS IN GENETICS

Alternative Polyadenylation: a new frontier in post transcriptional regulation

(2020) Fanggang Ren et al.   Biomarker Research

Ipa1 Is an RNA Polymerase II Elongation Factor that Facilitates Termination by Maintaining Levels of the Poly(A) Site Endonuclease Ysh1

(2019) Erika L. Pearson et al.   Cell Reports

Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex

(2019) Chris H. Hill et al.   MOLECULAR CELL

Nuclear eIF4E Stimulates 3′-End Cleavage of Target RNAs

(2019) Margaret Rose Davis et al.   Cell Reports

LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer

(2019) Kaili Luo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Alternative cleavage and polyadenylation in health and disease

(2019) Andreas J. Gruber et al.   NATURE REVIEWS GENETICS

JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing

(2019) Junya Kakegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

(2019) Christopher Swale et al.   Science Translational Medicine

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism

(2019) Michael A. Cortazar et al.   MOLECULAR CELL

Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery

(2019) Yixiao Zhang et al.   MOLECULAR CELL

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

(2019) Nathan T. Ross et al.   Nature Chemical Biology

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

(2018) Joshua D. Eaton et al.   GENES & DEVELOPMENT

Heat shock causes a reversible increase in RNA polymerase II occupancy downstream of mRNA genes consistent with a global loss in transcriptional termination

(2018) Joseph F. Cardiello et al.   MOLECULAR AND CELLULAR BIOLOGY

3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk

(2018) Hyun Jung Park et al.   NATURE GENETICS

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

(2018) Marcello Clerici et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker

(2018) Aleksandra Skrajna et al.   NUCLEIC ACIDS RESEARCH

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

(2018) Marcello Clerici et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

(2018) Richard J. Wall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Polymerase II Read-Through Promotes Expression of Neighboring Genes in SAL1-PAP-XRN Retrograde Signaling

(2018) Peter A. Crisp et al.   PLANT PHYSIOLOGY

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

(2018) Ilaria Pettinati et al.   eLife

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

(2017) Yadong Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative analysis reveals genomic features of stress-induced transcriptional readthrough

(2017) Anna Vilborg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage and polyadenylation: Ending the message expands gene regulation

(2017) Jonathan Neve et al.   RNA Biology

Birth and Death of Histone mRNAs

(2017) William F. Marzluff et al.   TRENDS IN GENETICS

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

(2017) Ebere Sonoiki et al.   Nature Communications

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

(2017) Marcello Clerici et al.   eLife

Alternative Polyadenylation: Another Foe in Cancer

(2016) A. E. Erson-Bensan et al.   MOLECULAR CANCER RESEARCH

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site

(2015) Yongsheng Shi et al.   GENES & DEVELOPMENT

Refining the treatment of NSCLC according to histological and molecular subtypes

(2015) Anish Thomas et al.   Nature Reviews Clinical Oncology

Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal

(2014) B. Lackford et al.   EMBO JOURNAL

CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing

(2014) Serena L. Chan et al.   GENES & DEVELOPMENT

Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33

(2014) Lars Schönemann et al.   GENES & DEVELOPMENT

Delineating the Structural Blueprint of the Pre-mRNA 3'-End Processing Machinery

(2014) K. Xiang et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Genome-Wide Mapping of Yeast RNA Polymerase II Termination

(2014) Paul Schaughency et al.   PLoS Genetics

Polyadenylation site–induced decay of upstream transcripts enforces promoter directionality

(2013) Evgenia Ntini et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors

(2013) I. Sabath et al.   RNA

A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing

(2012) X.-C. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Archaeal β-CASP ribonucleases of the aCPSF1 family are orthologs of the eukaryal CPSF-73 factor

(2012) Duy Khanh Phung et al.   NUCLEIC ACIDS RESEARCH

Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers

(2011) Svetlana Borozdenkova et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Characterization of Components of the Staphylococcus aureus mRNA Degradosome Holoenzyme-Like Complex

(2011) C. M. Roux et al.   JOURNAL OF BACTERIOLOGY

Structure and Activity of a Novel Archaeal β-CASP Protein with N-Terminal KH Domains

(2011) Ana P.G. Silva et al.   STRUCTURE

Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3' processing

(2010) Q. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii

(2010) Yuya Nishida et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

DOG 1.0: illustrator of protein domain structures

(2009) Jian Ren et al.   CELL RESEARCH

Poly(A) Tail Length Is Controlled by the Nuclear Poly(A)-binding Protein Regulating the Interaction between Poly(A) Polymerase and the Cleavage and Polyadenylation Specificity Factor

(2009) Uwe Kühn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Core Complex of CPSF73, CPSF100, and Symplekin May Form Two Different Cleavage Factors for Processing of Poly(A) and Histone mRNAs

(2009) Kelly D. Sullivan et al.   MOLECULAR CELL

FLASH, a Proapoptotic Protein Involved in Activation of Caspase-8, Is Essential for 3′ End Processing of Histone Pre-mRNAs

(2009) Xiao-cui Yang et al.   MOLECULAR CELL

Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex

(2009) Yongsheng Shi et al.   MOLECULAR CELL

CSR1 induces cell death through inactivation of CPSF3

(2008) Z-H Zhu et al.   ONCOGENE

Triple-negative/basal-like breast cancer: review

(2008) Emad A. Rakha et al.   PATHOLOGY