On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease
出版年份 2021 全文链接
标题
On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease
作者
关键词
CPSF73/CPSF3, polyadenylation, mRNA 3′ end processing, transcription termination, gene expression, cancer
出版物
TRENDS IN BIOCHEMICAL SCIENCES
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2021-04-30
DOI
10.1016/j.tibs.2021.04.003
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation
- (2020) Susan D. Lee et al. RNA Biology
- Structure of an active human histone pre-mRNA 3′-end processing machinery
- (2020) Yadong Sun et al. SCIENCE
- FttA is a CPSF73 homologue that terminates transcription in Archaea
- (2020) Travis J. Sanders et al. Nature Microbiology
- Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases
- (2020) Katarzyna Kaczmarek Michaels et al. NUCLEIC ACIDS RESEARCH
- Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5’-3’ exonuclease
- (2020) Xiao-cui Yang et al. RNA
- The Integrator Complex in Transcription and Development
- (2020) María Saraí Mendoza-Figueroa et al. TRENDS IN BIOCHEMICAL SCIENCES
- Termination of Transcription by RNA Polymerase II: BOOM!
- (2020) Joshua D. Eaton et al. TRENDS IN GENETICS
- Alternative Polyadenylation: a new frontier in post transcriptional regulation
- (2020) Fanggang Ren et al. Biomarker Research
- Ipa1 Is an RNA Polymerase II Elongation Factor that Facilitates Termination by Maintaining Levels of the Poly(A) Site Endonuclease Ysh1
- (2019) Erika L. Pearson et al. Cell Reports
- Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex
- (2019) Chris H. Hill et al. MOLECULAR CELL
- Nuclear eIF4E Stimulates 3′-End Cleavage of Target RNAs
- (2019) Margaret Rose Davis et al. Cell Reports
- LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer
- (2019) Kaili Luo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Alternative cleavage and polyadenylation in health and disease
- (2019) Andreas J. Gruber et al. NATURE REVIEWS GENETICS
- JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing
- (2019) Junya Kakegawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection
- (2019) Christopher Swale et al. Science Translational Medicine
- Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism
- (2019) Michael A. Cortazar et al. MOLECULAR CELL
- Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery
- (2019) Yixiao Zhang et al. MOLECULAR CELL
- CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
- (2019) Nathan T. Ross et al. Nature Chemical Biology
- Cancer statistics, 2018
- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity
- (2018) Joshua D. Eaton et al. GENES & DEVELOPMENT
- Heat shock causes a reversible increase in RNA polymerase II occupancy downstream of mRNA genes consistent with a global loss in transcriptional termination
- (2018) Joseph F. Cardiello et al. MOLECULAR AND CELLULAR BIOLOGY
- 3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
- (2018) Hyun Jung Park et al. NATURE GENETICS
- Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex
- (2018) Marcello Clerici et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker
- (2018) Aleksandra Skrajna et al. NUCLEIC ACIDS RESEARCH
- Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex
- (2018) Marcello Clerici et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Clinical and veterinary trypanocidal benzoxaboroles target CPSF3
- (2018) Richard J. Wall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA Polymerase II Read-Through Promotes Expression of Neighboring Genes in SAL1-PAP-XRN Retrograde Signaling
- (2018) Peter A. Crisp et al. PLANT PHYSIOLOGY
- Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease
- (2018) Ilaria Pettinati et al. eLife
- The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting
- (2017) Dongming Liang et al. MOLECULAR CELL
- Architecture of the human interactome defines protein communities and disease networks
- (2017) Edward L. Huttlin et al. NATURE
- Molecular basis for the recognition of the human AAUAAA polyadenylation signal
- (2017) Yadong Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparative analysis reveals genomic features of stress-induced transcriptional readthrough
- (2017) Anna Vilborg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cleavage and polyadenylation: Ending the message expands gene regulation
- (2017) Jonathan Neve et al. RNA Biology
- Birth and Death of Histone mRNAs
- (2017) William F. Marzluff et al. TRENDS IN GENETICS
- A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
- (2017) Ebere Sonoiki et al. Nature Communications
- Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex
- (2017) Marcello Clerici et al. eLife
- Alternative Polyadenylation: Another Foe in Cancer
- (2016) A. E. Erson-Bensan et al. MOLECULAR CANCER RESEARCH
- Alternative polyadenylation of mRNA precursors
- (2016) Bin Tian et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A global genetic interaction network maps a wiring diagram of cellular function
- (2016) M. Costanzo et al. SCIENCE
- A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances
- (2015) Marco Y. Hein et al. CELL
- The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
- (2015) Yongsheng Shi et al. GENES & DEVELOPMENT
- Refining the treatment of NSCLC according to histological and molecular subtypes
- (2015) Anish Thomas et al. Nature Reviews Clinical Oncology
- Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal
- (2014) B. Lackford et al. EMBO JOURNAL
- CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing
- (2014) Serena L. Chan et al. GENES & DEVELOPMENT
- Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33
- (2014) Lars Schönemann et al. GENES & DEVELOPMENT
- Delineating the Structural Blueprint of the Pre-mRNA 3'-End Processing Machinery
- (2014) K. Xiang et al. MOLECULAR AND CELLULAR BIOLOGY
- Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types
- (2014) Zheng Xia et al. Nature Communications
- Genome-Wide Mapping of Yeast RNA Polymerase II Termination
- (2014) Paul Schaughency et al. PLoS Genetics
- Polyadenylation site–induced decay of upstream transcripts enforces promoter directionality
- (2013) Evgenia Ntini et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- 3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors
- (2013) I. Sabath et al. RNA
- A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing
- (2012) X.-C. Yang et al. MOLECULAR AND CELLULAR BIOLOGY
- Archaeal β-CASP ribonucleases of the aCPSF1 family are orthologs of the eukaryal CPSF-73 factor
- (2012) Duy Khanh Phung et al. NUCLEIC ACIDS RESEARCH
- Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers
- (2011) Svetlana Borozdenkova et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Characterization of Components of the Staphylococcus aureus mRNA Degradosome Holoenzyme-Like Complex
- (2011) C. M. Roux et al. JOURNAL OF BACTERIOLOGY
- Structure and Activity of a Novel Archaeal β-CASP Protein with N-Terminal KH Domains
- (2011) Ana P.G. Silva et al. STRUCTURE
- Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3' processing
- (2010) Q. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii
- (2010) Yuya Nishida et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
- (2009) Christine Mayr et al. CELL
- DOG 1.0: illustrator of protein domain structures
- (2009) Jian Ren et al. CELL RESEARCH
- Poly(A) Tail Length Is Controlled by the Nuclear Poly(A)-binding Protein Regulating the Interaction between Poly(A) Polymerase and the Cleavage and Polyadenylation Specificity Factor
- (2009) Uwe Kühn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Core Complex of CPSF73, CPSF100, and Symplekin May Form Two Different Cleavage Factors for Processing of Poly(A) and Histone mRNAs
- (2009) Kelly D. Sullivan et al. MOLECULAR CELL
- FLASH, a Proapoptotic Protein Involved in Activation of Caspase-8, Is Essential for 3′ End Processing of Histone Pre-mRNAs
- (2009) Xiao-cui Yang et al. MOLECULAR CELL
- Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex
- (2009) Yongsheng Shi et al. MOLECULAR CELL
- CSR1 induces cell death through inactivation of CPSF3
- (2008) Z-H Zhu et al. ONCOGENE
- Triple-negative/basal-like breast cancer: review
- (2008) Emad A. Rakha et al. PATHOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started