Acrylamide and its metabolite induce neurotoxicity via modulation of protein kinase C and AMP-activated protein kinase pathways

Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways

(2020) Arulkumar Nagappan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain

(2020) Demetrio Raldúa et al.   Scientific Reports

Mechanistic Interplay between Autophagy and Apoptotic Signaling in Endosulfan-induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity

(2019) Chunjuan Song et al.   TOXICOLOGICAL SCIENCES

Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats

(2019) Mehdi Goudarzi et al.   NEUROLOGICAL RESEARCH

Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro

(2019) Cai Zong et al.   ARCHIVES OF TOXICOLOGY

Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling

(2019) Sam Tsz Wai Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes

(2019) Juan He et al.   Frontiers in Physiology

Alpha-lipoic acid alleviated 6-OHDA-induced cell damage by inhibiting AMPK/mTOR mediated autophagy

(2019) Lina Zhou et al.   NEUROPHARMACOLOGY

AMP-activated protein kinase inhibits MPP+-induced oxidative stress and apoptotic death of SH-SY5Y cells through sequential stimulation of Akt and autophagy

(2019) Maja Jovanovic-Tucovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of acrylamide on oxidant/antioxidant parameters and CYP2E1 expression in rat pancreatic endocrine cells

(2018) Jelena Marković et al.   ACTA HISTOCHEMICA

Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes

(2018) Ying Du et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

(2018) Julia A. Callender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acrylamide-induced oxidative stress and inflammatory response are alleviated by N -acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs

(2018) Xiaoqi Pan et al.   TOXICOLOGY LETTERS

Protective effect of calpeptin on acrylamide-induced microtubule injury in sciatic nerve

(2018) Qiangdong Guan et al.   TOXICOLOGY

Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells

(2017) Liang Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Evidence of acrylamide- and glycidamide-induced oxidative stress and apoptosis in Leydig and Sertoli cells

(2017) BO Yilmaz et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

(2017) Fang Wang et al.   Nature Communications

Protective effects of lipoic acid against acrylamide-induced neurotoxicity: involvement of mitochondrial energy metabolism and autophagy

(2017) Ge Song et al.   Food & Function

Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes

(2016) A. L. Katen et al.   BIOLOGY OF REPRODUCTION

Mitochondrion-Mediated Apoptosis Induced by Acrylamide is Regulated by a Balance Between Nrf2 Antioxidant and MAPK Signaling Pathways in PC12 Cells

(2016) Xiaoqi Pan et al.   MOLECULAR NEUROBIOLOGY

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

(2016) Ziyan Zhang et al.   NEUROCHEMICAL RESEARCH

Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury

(2016) Alicia K. Au et al.   Neurocritical Care

CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

(2016) Sung-Mi Kim et al.   Scientific Reports

Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells

(2015) Jong-Hang Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1–p70S6K–RPS6 signaling

(2015) Timothy D. Calamaras et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Acrylamide neurotoxicity

(2013) Pinar Erkekoglu et al.   NUTRITIONAL NEUROSCIENCE

Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells

(2013) Christopher J. Martyniuk et al.   TOXICOLOGY LETTERS

Neurotoxicity of Acrylamide in Exposed Workers

(2013) Manuela Pennisi et al.   International Journal of Environmental Research and Public Health

Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

(2012) Richard M. LoPachin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain

(2012) Dipti V Tillu et al.   Molecular Pain

Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells

(2012) M. Lin et al.   NEUROSCIENCE

Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway

(2012) Hyun-Gyo Lee et al.   NEUROTOXICOLOGY

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

Human CYP2E1 mediates the formation of glycidamide from acrylamide

(2008) Eva Settels et al.   ARCHIVES OF TOXICOLOGY

Acrylamide-Induced Nerve Terminal Damage: Relevance to Neurotoxic and Neurodegenerative Mechanisms

(2008) Richard M. LoPachin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents

(2008) Lars Ole Goffeng et al.   NEUROTOXICOLOGY AND TERATOLOGY