Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

Neuroinflammation, Hyperphosphorylated Tau, Diffuse Amyloid Plaques, and Down-Regulation of the Cellular Prion Protein in Air Pollution Exposed Children and Young Adults

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Cigarette Smoking is a Risk Factor for Alzheimer's Disease: An Analysis Controlling for Tobacco Industry Affiliation

(2017) Janine K. Cataldo et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of By-Products of Lipid Oxidation in Alzheimer's Disease Brain: A Focus on Acrolein

(2017) Manjeet Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Oxidative Stress in the Progression of Alzheimer's Disease

(2017) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy

(2011) Mohamed Ameen Ismahil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice

(2011) Sanjay Srivastava et al.   ATHEROSCLEROSIS

Application of the Hard and Soft, Acids and Bases (HSAB) Theory to Toxicant–Target Interactions

(2011) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

(2011) Kristofer S. Fritz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidative Stress, DNA Damage, and Inflammation Induced by Ambient Air and Wood Smoke Particulate Matter in Human A549 and THP-1 Cell Lines

(2011) Pernille Høgh Danielsen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular Mechanism of Glyceraldehyde-3-phosphate Dehydrogenase Inactivation by α,β-Unsaturated Carbonyl Derivatives

(2011) Christopher J. Martyniuk et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology

(2011) Johannes A. H. Schwöbel et al.   CHEMICAL REVIEWS

Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease

(2011) Shannon Levesque et al.   Journal of Neuroinflammation

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity

(2011) Lihai Zhang et al.   TOXICOLOGY LETTERS

Environmental Risk Factors for Heart Disease

(2011) T.E. O'Toole et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation

(2010) Alena Rudkouskaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox sensing: orthogonal control in cell cycle and apoptosis signalling

(2010) D. P. Jones   JOURNAL OF INTERNAL MEDICINE

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Potential Role of Acrolein in Neurodegeneration and in Alzheimers Disease

(2010) Dang Thanh Nam et al.   Current Molecular Pharmacology

α,β-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases

(2009) Nadia Moretto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periods

(2009) Miwa Takahashi et al.   ARCHIVES OF TOXICOLOGY

Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts

(2009) Jian Cai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation

(2009) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acrylamide as environmental noxious agent

(2009) Birgitta Kütting et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats

(2009) Joan Garey et al.   NEUROTOXICOLOGY AND TERATOLOGY

Evaluation of human relevance and mode of action for tunica vaginalis mesotheliomas resulting from oral exposure to acrylamide

(2009) Lynne T. Haber et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water

(2009) John F. Bowyer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acrolein consumption induces systemic dyslipidemia and lipoprotein modification

(2009) Daniel J. Conklin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nasal Uptake of Inhaled Acrolein in Rats

(2008) Melanie F. Struve et al.   INHALATION TOXICOLOGY

Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes

(2008) Paul A. Grimsrud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCε signaling and cardioprotection

(2008) Guang-Wu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Critical role of acrolein in secondary injury followingex vivospinal cord trauma

(2008) Kristin Hamann et al.   JOURNAL OF NEUROCHEMISTRY

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases

(2008) Richard M. LoPachin et al.   NEUROTOXICOLOGY

Neurobehavioral effects of ambient air pollution on cognitive performance in US adults

(2008) Jiu-Chiuan Chen et al.   NEUROTOXICOLOGY

Smoke chemistry, in vitro and in vivo toxicology evaluations of the electrically heated cigarette smoking system series K

(2008) Michael S. Werley et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Synaptosomal Toxicity and Nucleophilic Targets of 4-Hydroxy-2-Nonenal

(2008) Richard M. LoPachin et al.   TOXICOLOGICAL SCIENCES

Acrolein environmental levels and potential for human exposure

(2008) O Faroon et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Smoking, dementia and cognitive decline in the elderly, a systematic review

(2008) Ruth Peters et al.   BMC Geriatrics

Smoking Is Associated With Reduced Cortical Regional Gray Matter Density in Brain Regions Associated With Incipient Alzheimer Disease

(2007) Osvaldo P. Almeida et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Protein Damage by Reactive Electrophiles: Targets and Consequences

(2007) Daniel C. Liebler   CHEMICAL RESEARCH IN TOXICOLOGY