CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

Regulation of AMP-activated protein kinase by natural and synthetic activators

(2016) David Grahame Hardie   Acta Pharmaceutica Sinica B

Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine

(2015) Mazen Noureddin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH)

(2014) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Liver Cytochrome P450 3A4 Ubiquitination

(2014) YongQiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: Hey U(PS): Metabolic and Proteolytic Homeostasis Linked via AMPK and the Ubiquitin Proteasome System

(2014) Sarah M. Ronnebaum et al.   MOLECULAR ENDOCRINOLOGY

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

(2014) Jörn M. Schattenberg et al.   Redox Biology

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis

(2013) Priya Handa et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

CHIP protects against cardiac pressure overload through regulation of AMPK

(2013) Jonathan C. Schisler et al.   JOURNAL OF CLINICAL INVESTIGATION

Forkhead box class O transcription factors in liver function and disease

(2013) Irina Tikhanovich et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK

(2013) Defeng Wu et al.   Redox Biology

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

(2012) Geoffrey C. Farrell et al.   Gut and Liver

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism

(2012) Xiwen Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF2 – at the crossroad of nuclear and cytosolic functions

(2012) Eric Lau et al.   JOURNAL OF CELL SCIENCE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2−/− but not in c-Jun N-terminal kinase 1−/− mice

(2011) Xiaodong Wang et al.   HEPATOLOGY

Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1

(2011) YongQiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1

(2011) H Gaude et al.   ONCOGENE

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

(2011) Hong Wa Yung et al.   PLoS One

New Insights from Rodent Models of Fatty Liver Disease

(2010) Jacquelyn J. Maher   ANTIOXIDANTS & REDOX SIGNALING

Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling

(2010) Peter L.J. de Keizer et al.   ANTIOXIDANTS & REDOX SIGNALING

Liver Cytochrome P450 3A Ubiquitinationin Vivoby gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

(2010) Sung-Mi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

JNK regulation of hepatic manifestations of the metabolic syndrome

(2010) Mark J. Czaja   TRENDS IN ENDOCRINOLOGY AND METABOLISM

C Terminus of Hsc70-interacting Protein Promotes Smooth Muscle Cell Proliferation and Survival through Ubiquitin-mediated Degradation of FoxO1

(2009) Fang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mitochondria-Targeted Triphenylphosphonium-Conjugated Nitroxide Functions as a Radioprotector/Mitigator

(2009) Jianfei Jiang et al.   RADIATION RESEARCH

The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis

(2008) J.-Y. Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY