The Inside-Out of End-Stage Liver Disease: Hepatocytes are the Keystone

OPTN/SRTR 2018 Annual Data Report: Liver

(2020) A. Kwong et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The myths and realities of portopulmonary hypertension

(2020) Hilary M. DuBrock et al.   HEPATOLOGY

Telomere dysfunction activates p53 and represses HNF4α expression leading to impaired human hepatocyte development and function

(2020) Michael Munroe et al.   HEPATOLOGY

Treatment of Hepatitis C: A New Paradigm toward Viral Eradication

(2020) James E. Squires et al.   JOURNAL OF PEDIATRICS

Understanding, predicting and achieving liver transplant tolerance: from bench to bedside

(2020) Angus W. Thomson et al.   Nature Reviews Gastroenterology & Hepatology

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

A Critical Review of MELD as a Reliable Tool for Transplant Prioritization

(2019) Sophie-Caroline Sacleux et al.   SEMINARS IN LIVER DISEASE

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

(2019) Josepmaria Argemi et al.   Nature Communications

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

(2019) Kai-Wen Huang et al.   Molecular Therapy-Nucleic Acids

Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor (EGFR) Signaling Causes Liver Failure in Normal Mice

(2018) Anastasia Tsagianni et al.   AMERICAN JOURNAL OF PATHOLOGY

Predictors of clinical outcomes in cirrhosis patients

(2018) Mona Haj et al.   CURRENT OPINION IN GASTROENTEROLOGY

Potential clinical targets in hepatopulmonary syndrome: lessons from experimental models

(2018) Sarah Raevens et al.   HEPATOLOGY

Cirrhotic cardiomyopathy

(2018) Søren Møller et al.   JOURNAL OF HEPATOLOGY

The molecular functions of hepatocyte nuclear factors – In and beyond the liver

(2018) Hwee Hui Lau et al.   JOURNAL OF HEPATOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Liver Transplantation Today: Where we are now and where we are going

(2018) Adam S. Bodzin et al.   LIVER TRANSPLANTATION

Gap junctions in liver disease: Implications for pathogenesis and therapy

(2018) Manuel Hernández-Guerra et al.   JOURNAL OF HEPATOLOGY

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation

(2017) David Goldberg et al.   GASTROENTEROLOGY

Hepatostat: Liver regeneration and normal liver tissue maintenance

(2017) George K. Michalopoulos   HEPATOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation

(2016) Shirish Paranjpe et al.   HEPATOLOGY

Loss of G s α impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling

(2016) Changli Lu et al.   JOURNAL OF HEPATOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Acute-on-chronic liver failure: terminology, mechanisms and management

(2016) Shiv K. Sarin et al.   Nature Reviews Gastroenterology & Hepatology

Antifibrotic Therapies: Where Are We Now?

(2016) Young Yoon et al.   SEMINARS IN LIVER DISEASE

Liver transplantation: Current status and challenges

(2016) Caroline C Jadlowiec   WORLD JOURNAL OF GASTROENTEROLOGY

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Promotion of mitochondrial energy metabolism during hepatocyte apoptosis in a rat model of acute liver failure

(2015) LI-YAN CHEN et al.   Molecular Medicine Reports

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

Future Economics of Liver Transplantation: A 20-Year Cost Modeling Forecast and the Prospect of Bioengineering Autologous Liver Grafts

(2015) Dany Habka et al.   PLoS One

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

(2014) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease

(2014) Taichiro Nishikawa et al.   JOURNAL OF HEPATOLOGY

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

Transcriptional Regulation and Its Misregulation in Disease

(2013) Tong Ihn Lee et al.   CELL

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver transplantation: past, present and future

(2013) Ali Zarrinpar et al.   Nature Reviews Gastroenterology & Hepatology

Gap junctional communication promotes apoptosis in a connexin-type-dependent manner

(2013) P Kameritsch et al.   Cell Death & Disease

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functional aspects on the pathophysiology of portal hypertension in cirrhosis

(2012) Juan-Carlos García-Pagán et al.   JOURNAL OF HEPATOLOGY

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

(2012) Kakajan Komurov et al.   Molecular Systems Biology

Connexins and Diabetes

(2012) Josephine A. Wright et al.   Cardiology Research and Practice

Metabolomics for mitochondrial and cancer studies

(2011) Deepak Nagrath et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis

(2011) Liping Liu et al.   HEPATOLOGY

Renal failure and cirrhosis: A systematic review of mortality and prognosis

(2011) Giuseppe Fede et al.   JOURNAL OF HEPATOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

The Ratio of Th-17 to Treg Cells is Associated with Survival of Patients with Acute-on-Chronic Hepatitis B Liver Failure

(2011) Song Zhai et al.   VIRAL IMMUNOLOGY

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney

(2010) Tomonori Kanazawa et al.   DEVELOPMENTAL DYNAMICS

Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis

(2010) Vasiliki Arvaniti et al.   GASTROENTEROLOGY

Hepatic venous pressure gradient in 2010: Optimal measurement is key

(2010) Andrew K. Burroughs et al.   HEPATOLOGY

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Clinical course of alcoholic liver cirrhosis: A Danish population-based cohort study

(2009) Peter Jepsen et al.   HEPATOLOGY

Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis

(2009) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

Management of adult patients with ascites due to cirrhosis: An update

(2009) Bruce A. Runyon   HEPATOLOGY

Angiogenesis in liver disease

(2009) Mercedes Fernández et al.   JOURNAL OF HEPATOLOGY

The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease

(2008) Young-Suk Lim et al.   Clinics in Liver Disease

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE