Article
Chemistry, Medicinal
Rachel J. J. Stephenson, Istvan Toth
Summary: Cocaine is a widely used illegal drug that has significant medical and social consequences. The lack of effective pharmacological treatments has led to the development of anti-cocaine vaccines. Despite years of research, no approved pharmacological treatments exist to help individuals overcome cocaine addiction or prevent relapse.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Nursing
Barbara Riegel, Sandra B. Dunbar, Donna Fitzsimons, Kenneth E. Freedland, Christopher S. Lee, Sandy Middleton, Anna Stromberg, Ercole Vellone, David E. Webber, Tiny Jaarsma
Summary: This article discusses the importance and objectives of self-care research, proposes a future research agenda, and shares the vision and mission of a research center dedicated to self-care. It emphasizes the importance of addressing challenges in self-care and strategies to tackle knowledge gaps.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Medicine, General & Internal
Melissa J. Alldred, Alessandra C. Martini, David Patterson, James Hendrix, Ann-Charlotte Granholm
Summary: Down syndrome is a form of accelerated aging due to the overexpression of multiple genes on Chromosome 21, leading to a predisposition to aging-related conditions and significant accumulation of abnormalities in the brain. This review highlights the major advancements in research over the past few decades, current research status, and essential areas for future studies, as well as discussing comorbidities and clinical research efforts in the United States and Europe. The review also addresses funding efforts and recent recommendations to the NIH regarding research on Down syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Neda Rahimian, Hamid Reza Miraei, Atefeh Amiri, Mohammad Saeid Ebrahimi, Javid Sadri Nahand, Hossein Tarrahimofrad, Michael R. Hamblin, Haroon Khan, Hamed Mirzaei
Summary: Therapeutic vaccines are effective in treating cancer at later stages, with the recent approval of the first therapeutic cancer vaccine by the FDA. Further studies are expected to lead to the development of vaccines with improved efficacy.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Albert Jang, David M. Adler, Grant P. Rauterkus, Mehmet A. Bilen, Pedro C. Barata
Summary: Genitourinary malignancies encompass various cancers along the urinary and male reproductive tracts. Traditional immunotherapies have shown success in treating certain types of these cancers, while immune checkpoint inhibitors have emerged as a more precise method to enhance the immune system's ability to fight tumor cells. Despite promising data from clinical trials, there is still limited understanding of biomarkers that can predict response to these inhibitors, and the efficacy of ICIs varies across different tumor types in the genitourinary system.
Editorial Material
Cell Biology
Md Mobashir Hasan Shandhi, Jessilyn P. Dunn
Summary: Advancements in AI have enabled personalized healthcare by investigating disease origins at the genetic or molecular level, understanding individual drug effects, and integrating multi-modal personal data to uncover new aspects of pathophysiology. Future efforts should focus on addressing equity, fairness, explainability, and generalizability of AI models.
CELL REPORTS MEDICINE
(2022)
Review
Chemistry, Physical
Swaminath Bharadwaj, Bart-Jan Niebuur, Katja Nothdurft, Walter Richtering, Nico F. A. van der Vegt, Christine M. Papadakis
Summary: Cononsolvency is an intriguing phenomenon where a polymer collapses in a mixture of good solvents. It has been widely observed in different systems and has applications in various fields. In the past decade, there has been a renewed interest in understanding the molecular mechanisms driving cononsolvency.
Review
Oncology
Huihua Zeng, Fen Liu, Hairong Zhou, Changchun Zeng
Summary: Innovative research in cancer biology and immunology has revolutionized the management of patients with melanoma, providing new therapies like targeted therapy and immunotherapy. Despite significant therapeutic outcomes, some patients still experience therapeutic resistance and disease recurrence, emphasizing the need for further understanding of genetic variations and personalized treatment options for melanoma.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Jules Mesnier, Vassili Panagides, Jorge Nuche, Josep Rodes-Cabau
Summary: This article summarizes the current indications for transcatheter aortic valve replacement (TAVR) and explores future directions for its expansion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Multidisciplinary Sciences
Kailibinuer Abulikemu, Fengxia Hu, Junqin Liang, Xiaojing Kang
Summary: Pemphigus refers to a group of autoimmune skin disorders characterized by blistering, which can negatively impact quality of life. The current standard treatment involves the use of systemic corticosteroids and immunosuppressive agents, but their long-term use can lead to serious side effects. Therefore, researchers are exploring new and safer therapeutic approaches.
Review
Ophthalmology
Alyse J. Richard, Jacob S. Duker, Elias Reichel
Summary: AMD is a common eye disease in the elderly population, with no current treatments to prevent the onset or progression of GA. Ophthalmic research has made significant advancements in disease characterization, genetic and environmental risk factor classification, biomarker discovery, and mechanism of pathogenesis categorization. Multiple clinical treatment trials targeting proposed pathways and biomarkers associated with GA are in progress, showing promising results.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zuming Zhang, Zihui Xu, Fa Yuan, Kangxin Jin, Mengqing Xiang
Summary: This article discusses the historical background of retinal organoid technology, current methods of organoid induction, obstacles and potential solutions for next-generation retinal organoids, research progress in cell/tissue transplantation to treat retinal diseases, and the pros and cons of transplanting single-cell suspension versus retinal organoid sheet for cell therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
I. Lisko, J. Kulmala, M. Annetorp, T. Ngandu, F. Mangialasche, M. Kivipelto
Summary: The aging population has led to a significant increase in older individuals living with dementia and disabilities, with dementia identified as the main cause of disability in old age. The World Health Organization's risk reduction guidelines highlight 12 modifiable risk factors that could contribute to approximately 40% of dementia cases worldwide. The FINGER trial has shown that multidomain lifestyle-based intervention can prevent cognitive and functional decline in at-risk older adults, supporting the need for integrated preventive interventions to address the shared risk factors between dementia and physical disability.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Physiology
Paresh C. Giri, Anand M. Chowdhury, Armando Bedoya, Hengji Chen, Hyun Suk Lee, Patty Lee, Craig Henriquez, Neil R. MacIntyre, Yuh-Chin T. Huang
Summary: Machine learning has the potential to greatly benefit the analysis of pulmonary function tests by improving interpretation accuracy, discovering novel physiological biomarkers, and enabling precision medicine by combining mobile spirometry results with clinical profiles. However, there are challenges in developing and commercializing ML-assisted PFT interpretation programs, including the need for high quality data, varying data formats, and the importance of collaboration among clinicians, biomedical engineers, and information technologists. Despite these hurdles, the future advancements in this field represent significant progress for PFT in clinical medicine.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Business
Sher Jahan Khan, Puneet Kaur, Fauzia Jabeen, Amandeep Dhir
Summary: Environmental pollution has worsened in recent decades, putting pressure on firms to adopt green process innovations. However, existing literature on GPcIs is disjointed, lacking a comprehensive understanding. A systematic literature review identified seven themes and gaps in the literature, suggesting future research directions.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2021)