The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors

Uric Acid and Arterial Stiffness

(2020) Adriana Albu et al.   Therapeutics and Clinical Risk Management

Allopurinol hypersensitivity: Pathogenesis and prevention

(2020) Lisa K. Stamp et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury

(2020) Quan Hong et al.   MEDIATORS OF INFLAMMATION

Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury

(2020) Hong-yong Su et al.   Biomed Research International

Renal lipid accumulation, oxidative stress and uric acid handling in a rodent model of obesity and metabolic syndrome

(2020) Tara R Rosenthal et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Rest-Phase Hypothermia Reveals a Link Between Aging and Oxidative Stress: A Novel Hypothesis

(2020) Elisavet Zagkle et al.   Frontiers in Physiology

Inhibitors of Xanthine Oxidase: Scaffold Diversity and Structure-Based Drug Design

(2019) Giuseppe Luna et al.   ChemMedChem

Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cyto-toxicity

(2019) Hina Qamar et al.   CURRENT DRUG TARGETS

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

(2019) Daniel B. Harmon et al.   DIABETES

Synthesis and biological evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole derivatives as xanthine oxidase inhibitors

(2019) Song-ye Li et al.   Medicinal Chemistry

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice

(2019) Yu Mizuno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Beyond urate lowering: Analgesic and anti-inflammatory properties of allopurinol

(2019) Naomi Schlesinger et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats

(2019) Jierong Luo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Severe Hypouricemia Impairs Endothelium‐Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo‐Controlled, and Crossover Study

(2019) Benjamin De Becker et al.   Journal of the American Heart Association

The role of xanthine oxidoreductase and uric acid in metabolic syndrome

(2018) Maria Giulia Battelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Uric acid and cardiovascular disease

(2018) Gjin Ndrepepa   CLINICA CHIMICA ACTA

Investigational drugs for hyperuricemia, an update on recent developments

(2018) Tristan Pascart et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanistic insights into the inhibition of quercetin on xanthine oxidase

(2018) Cen Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study

(2018) Masanari Shiramoto et al.   RHEUMATOLOGY

Levels of cytokines and microRNAs in individuals with asymptomatic hyperuricemia and ultrasonographic findings of gout: a bench-to-bedside approach

(2018) Irving O. Estevez-Garcia et al.   ARTHRITIS CARE & RESEARCH

Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate

(2018) Anne Ruiz et al.   Frontiers in Physiology

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial

(2018) Kenjiro Kimura et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The teratogenicity of allopurinol: A comprehensive review of animal and human studies

(2018) Melek Simsek et al.   REPRODUCTIVE TOXICOLOGY

Uric Acid and Cognitive Function in Older Individuals

(2018) Claudio Tana et al.   Nutrients

Association of Gout With Long‐Term Cardiovascular Outcomes Among Patients With Obstructive Coronary Artery Disease

(2018) Neha J. Pagidipati et al.   Journal of the American Heart Association

Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy

(2018) Jing Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

Natural Compounds with xanthine oxidase inhibitory activity: A review

(2018) Arshad Mehmood et al.   Chemical Biology & Drug Design

Mechanistic insights of soluble uric acid-related kidney disease

(2018) Jing Pan et al.   CURRENT MEDICINAL CHEMISTRY

How should we manage asymptomatic hyperuricemia?

(2018) Gérard Chalès   JOINT BONE SPINE

Relationship between oxidative stress and inflammation in hyperuricemia

(2018) You Zhou et al.   MEDICINE

Association of Chronic Kidney Disease With Allopurinol Use in Gout Treatment

(2018) Ana Beatriz Vargas-Santos et al.   JAMA Internal Medicine

Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase

(2018) Maria Giulia Battelli et al.   Redox Biology

Acupuncture for serum uric acid in patients with asymptomatic hyperuricemia: A randomized, double-blind, placebo-controlled trial

(2017) Yingjuan Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction

(2017) Theodoros Eleftheriadis et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases

(2017) Raj Kumar et al.   MEDICINAL RESEARCH REVIEWS

Long-term allopurinol use decreases the risk of prostate cancer in patients with gout: a population-based study

(2017) H-J Shih et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Recent pharmacological advances in the management of gout

(2017) Kristen Davies et al.   RHEUMATOLOGY

Effects of Febuxostat in Early Gout

(2017) Nicola Dalbeth et al.   Arthritis & Rheumatology

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial

(2017) Theodoros Eleftheriadis et al.   Journal of Advanced Research

Update on Importance of Diet in Gout

(2016) Randall N. Beyl et al.   AMERICAN JOURNAL OF MEDICINE

A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia

(2016) Martin Windpessl et al.   AMERICAN JOURNAL OF NEPHROLOGY

Structure and function of mammalian aldehyde oxidases

(2016) Mineko Terao et al.   ARCHIVES OF TOXICOLOGY

9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors

(2016) Marili V.N. Rodrigues et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

(2016) Jeong Uk Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study

(2016) Tatsuo Hosoya et al.   CLINICAL RHEUMATOLOGY

Xanthine oxidoreductase and its inhibitors: relevance for gout

(2016) R. O. Day et al.   CLINICAL SCIENCE

Uric acid in metabolic syndrome: From an innocent bystander to a central player

(2016) Mehmet Kanbay et al.   European Journal of Internal Medicine

Allopurinol: insights from studies of dose–response relationships

(2016) Richard O. Day et al.   Expert Opinion on Drug Metabolism & Toxicology

An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015)

(2016) Ritu Ojha et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The treatment of hyperuricemia

(2016) Micaela Gliozzi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Regulation of uric acid metabolism and excretion

(2016) Jessica Maiuolo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Allopurinol and kidney function: An update

(2016) Lisa K. Stamp et al.   JOINT BONE SPINE

Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double-blind, placebo-controlled study

(2016) T. Hosoya et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Gout

(2016) Nicola Dalbeth et al.   LANCET

Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects

(2016) Maria Giulia Battelli et al.   Oxidative Medicine and Cellular Longevity

Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview

(2016) Changyi Chen et al.   MEDICAL SCIENCE MONITOR

The Molecular Physiology of Uric Acid Homeostasis

(2015) Asim K. Mandal et al.   Annual Review of Physiology

Dispelling dogma and misconceptions regarding the most pharmacologically targetable source of reactive species in inflammatory disease, xanthine oxidoreductase

(2015) Eric E. Kelley   ARCHIVES OF TOXICOLOGY

Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment

(2015) Daisuke Kadowaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Molecular basis of oxidative stress in gouty arthropathy

(2015) Yessica Zamudio-Cuevas et al.   CLINICAL RHEUMATOLOGY

Effects of Febuxostat on Oxidative Stress

(2015) Toshiki Fukui et al.   CLINICAL THERAPEUTICS

Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors

(2015) Shaolei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase

(2015) Tomoko Nishino et al.   FEBS Journal

Serum uric acid and the risk of cardiovascular and renal disease

(2015) Claudio Borghi et al.   JOURNAL OF HYPERTENSION

Allopurinol hypersensitivity: investigating the cause and minimizing the risk

(2015) Lisa K. Stamp et al.   Nature Reviews Rheumatology

Renal Oxidative Stress Induced by Long-Term Hyperuricemia Alters Mitochondrial Function and Maintains Systemic Hypertension

(2015) Magdalena Cristóbal-García et al.   Oxidative Medicine and Cellular Longevity

EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway

(2015) Hua Xie et al.   Oxidative Medicine and Cellular Longevity

Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents fromPlumula nelumbinis

(2015) Xiao Ding et al.   Journal of Chemistry

Xanthine oxidoreductase in cancer: more than a differentiation marker

(2015) Maria Giulia Battelli et al.   Cancer Medicine

Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress

(2014) Maria Giulia Battelli et al.   ATHEROSCLEROSIS

Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme

(2014) Maria Giulia Battelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperuricemia

(2014) Kiyoko Kaneko et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives

(2014) Deependra Kumar et al.   BIOORGANIC CHEMISTRY

ALDR Enhanced Endothelial Injury in Hyperuricemia Screened using SILAC

(2014) Yang Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout

(2014) Tatsuo Hosoya et al.   Clinical and Experimental Nephrology

Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis

(2014) You-Jin Choi et al.   FASEB JOURNAL

3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: A potential therapeutic agent for treatment of hyperuricemia and gout

(2013) Jian-Ming Lü et al.   BIOCHEMICAL PHARMACOLOGY

Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors

(2013) Sahil Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In VitroEvaluation of Selected Benzimidazole Derivatives as an Antioxidant and Xanthine Oxidase Inhibitors

(2013) Shivraj H. Nile et al.   Chemical Biology & Drug Design

Sugar, Uric Acid, and the Etiology of Diabetes and Obesity

(2013) R. J. Johnson et al.   DIABETES

Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis

(2013) Bruce N. Cronstein et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Genetic Disorders Resulting in Hyper- or Hypouricemia

(2012) Ivan Sebesta   ADVANCES IN CHRONIC KIDNEY DISEASE

The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome

(2012) Andréa Name Colado Simão et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Uric Acid-Induced Endothelial Dysfunction Is Associated with Mitochondrial Alterations and Decreased Intracellular ATP Concentrations

(2012) Laura Gabriela Sánchez-Lozada et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

High plasma uric acid concentration: causes and consequences

(2012) Erick Prado de Oliveira et al.   Diabetology & Metabolic Syndrome

N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors

(2011) Kunal Nepali et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effect of nitric oxide on mitochondrial activity of human synovial cells

(2011) Berta Cillero-Pastor et al.   BMC MUSCULOSKELETAL DISORDERS

Uric acid, hyperuricemia and vascular diseases

(2011) Ming Jin   Frontiers in Bioscience-Landmark

Recent advances in management of gout

(2011) E. Suresh et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Xanthine Oxidase and Uric Acid in Cardiovascular Disease: Clinical Impact and Therapeutic Options

(2011) Wolfram Doehner et al.   SEMINARS IN NEPHROLOGY

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolism and Excretion of [14C] Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase, in Healthy Male Subjects

(2010) Brian A. Grabowski et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction

(2010) Min-A Yu et al.   JOURNAL OF HYPERTENSION

Insights into the inhibition of xanthine oxidase by curcumin

(2009) Liang Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure

(2009) Corinna Bergamini et al.   EUROPEAN JOURNAL OF HEART FAILURE

Xanthine Oxidoreductase Depletion Induces Renal Interstitial Fibrosis Through Aberrant Lipid and Purine Accumulation in Renal Tubules

(2009) Toshio Ohtsubo et al.   HYPERTENSION

Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin–angiotensin system

(2009) Dalila B Corry et al.   JOURNAL OF HYPERTENSION

Clinical Efficacy and Safety of Successful Longterm Urate Lowering with Febuxostat or Allopurinol in Subjects with Gout

(2009) M. A. BECKER et al.   JOURNAL OF RHEUMATOLOGY

Gout

(2009) Pascal Richette et al.   LANCET

Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia

(2008) Chao-Liang Long et al.   JOURNAL OF HYPERTENSION

Uric Acid: The Oxidant-Antioxidant Paradox

(2008) Yuri Y. Sautin et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS