Inhibitors of Xanthine Oxidase: Scaffold Diversity and Structure-Based Drug Design

Synthesis, structure-activity relationships, and mechanistic studies of 5-arylazo-tropolone derivatives as novel xanthine oxidase (XO) inhibitors

(2018) Daisuke Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1 H -tetrazoles

(2018) Itrat Fatima et al.   BIOORGANIC CHEMISTRY

Novel Xanthine Oxidase (XO) inhibitory phenylindanes produced by thermal reaction of caffeic acid

(2018) Yuya Fukuyama et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[ b ]furan scaffold

(2018) Hong-Jin Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1 H -imidazole derivatives as xanthine oxidase inhibitors

(2018) Tingjian Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors

(2018) Ailong Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, screening and docking of fused pyrano[3,2- d ]pyrimidine derivatives as xanthine oxidase inhibitor

(2017) Manroopraj Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of N -(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives as novel xanthine oxidase inhibitors

(2017) Ting-jian Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors

(2016) Marili V.N. Rodrigues et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

(2016) Jeong Uk Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[ b ]furan derivatives based on salvianolic acid C

(2016) Hong-Jin Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG–AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases

(2016) Jun Fang et al.   JOURNAL OF CONTROLLED RELEASE

2-Arylquinazolin-4(3H)-ones: Inhibitory Activities Against Xanthine Oxidase

(2016) Humaira Zafar et al.   Medicinal Chemistry

Use of Osteoporosis Medications after Hospitalization for Hip Fracture: A Cross-national Study

(2015) Seoyoung C. Kim et al.   AMERICAN JOURNAL OF MEDICINE

Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors

(2015) Jeong Uk Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Novel Aryl-2H-pyrazole Derivatives as Potent Non-purine Xanthine Oxidase Inhibitors

(2015) Zhi-Gang Sun et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers

(2015) Md Rahmat Ali et al.   Chemical Biology & Drug Design

Xanthine oxidase inhibitory properties and anti-inflammatory activity of 2-amino-5-alkylidene-thiazol-4-ones

(2015) Zaklina Smelcerovic et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors

(2015) Shaolei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors

(2015) Harpreet S. Virdi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, crystal structures, fluorescence and xanthine oxidase inhibitory activity of pyrazole-based 1,3,4-oxadiazole derivatives

(2015) De-Qiang Qi et al.   JOURNAL OF MOLECULAR STRUCTURE

Screening of a library of 4-aryl/heteroaryl-4H-fused pyrans for xanthine oxidase inhibition: synthesis, biological evaluation and docking studies

(2015) Ramandeep Kaur et al.   MEDICINAL CHEMISTRY RESEARCH

Xanthine Oxidase: Isolation, Assays of Activity, and Inhibition

(2015) Danijela A. Kostić et al.   Journal of Chemistry

4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a New Class of Xanthine Oxidase Inhibitors

(2014) Shiwani Shukla et al.   ARCHIV DER PHARMAZIE

Synthesis and evaluation of naphthoflavones as a new class of non purine xanthine oxidase inhibitors

(2014) Harbinder Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase

(2014) Johan Evenäs et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives

(2014) Deependra Kumar et al.   BIOORGANIC CHEMISTRY

Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout

(2014) Tatsuo Hosoya et al.   Clinical and Experimental Nephrology

Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors

(2014) Qi Guan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Augmenting the Xanthine Oxidase Inhibitory Activity of Febuxostat by its Structural Modification

(2014) Kuruva Chandra Sekhar et al.   Letters in Drug Design & Discovery

Synthesis, Antioxidant, and Xanthine Oxidase Inhibitory Activities of 5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione Derivatives

(2013) A. Bushra Begum et al.   ARCHIV DER PHARMAZIE

3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: A potential therapeutic agent for treatment of hyperuricemia and gout

(2013) Jian-Ming Lü et al.   BIOCHEMICAL PHARMACOLOGY

Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors

(2013) Sahil Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In VitroEvaluation of Selected Benzimidazole Derivatives as an Antioxidant and Xanthine Oxidase Inhibitors

(2013) Shivraj H. Nile et al.   Chemical Biology & Drug Design

Serum uric acid and gout: from the past to molecular biology

(2013) L. Punzi et al.   CURRENT MEDICAL RESEARCH AND OPINION

Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk

(2013) Davide Grassi et al.   CURRENT PHARMACEUTICAL DESIGN

Two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones as new non-purine xanthine oxidase inhibitors and anti-inflammatory agents

(2013) Andrija Smelcerovic et al.   FOOD AND CHEMICAL TOXICOLOGY

Study on the activity of non-purine xanthine oxidase inhibitor by 3D-QSAR modeling and molecular docking

(2013) Peizhen Li et al.   JOURNAL OF MOLECULAR STRUCTURE

Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

(2012) Chandrika B-Rao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors

(2012) Babasaheb P. Bandgar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

(2012) Smriti Khanna et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lead optimization of isocytosine-derived xanthine oxidase inhibitors

(2012) Komal Bajaj et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel thiazolo-pyrazolyl derivatives as xanthine oxidase inhibitors and free radical scavengers

(2012) Supriya D. Beedkar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The gout pipeline crystallizes

(2012) Joanne Kotz   NATURE REVIEWS DRUG DISCOVERY

Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout

(2012) R. Grainger et al.   RHEUMATOLOGY

N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors

(2011) Kunal Nepali et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors

(2011) Kunal Nepali et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gout. Epidemiology of gout

(2011) Edward Roddy et al.   ARTHRITIS RESEARCH & THERAPY

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives

(2010) K.R. Sathisha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chronic gout: epidemiology, disease progression, treatment and disease burden

(2010) Richard A. Brook et al.   CURRENT MEDICAL RESEARCH AND OPINION

Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors

(2010) Shaojie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene–maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia–reperfusion injury

(2010) Jun Fang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Substrate Orientation and Catalytic Specificity in the Action of Xanthine Oxidase

(2010) Hongnan Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase

(2010) K. Matsumoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate

(2010) Ken Okamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gout therapeutics: new drugs for an old disease

(2010) Christopher M Burns et al.   LANCET

Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect?

(2010) Ankoor Shah et al.   Current Rheumatology Reports

Management of hyperuricemia in gout: focus on febuxostat

(2010) Mark Reinders et al.   Clinical Interventions in Aging

Therapeutic strategies by modulating oxygen stress in cancer and inflammation

(2009) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia

(2009) Takahiro Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitors

(2009) Hamed I. Ali et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

SMA–copolymer conjugate of AHPP: A polymeric inhibitor of xanthine oxidase with potential antihypertensive effect

(2009) Jun Fang et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives:in silicoapproach

(2009) Chandrahas N. Khobragade et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Gout

(2009) Pascal Richette et al.   LANCET

New relief for gout

(2009) Jill U Adams   NATURE BIOTECHNOLOGY

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

(2009) H. Matsuo et al.   Science Translational Medicine

Structure–activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities

(2008) Hsiu-Chen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors

(2008) Takahiro Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted Pyrazolo[3,4-d]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation

(2008) Ana M. F. Oliveira-Campos et al.   HELVETICA CHIMICA ACTA

Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase

(2008) James M. Pauff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

Mechanism of Inhibition of Xanthine Oxidoreductase by Allopurinol: Crystal Structure of Reduced Bovine Milk Xanthine Oxidoreductase Bound with Oxipurinol

(2008) Ken Okamoto et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors

(2007) Sanjay Gupta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY