Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

(2020) Lettine van den Brink et al.   Stem Cell Research

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

(2020) Idit Goldfracht et al.   Nature Communications

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

(2020) Elisa Giacomelli et al.   Cell Stem Cell

The Role of Membrane Capacitance in Cardiac Impulse Conduction: An Optogenetic Study With Non-excitable Cells Coupled to Cardiomyocytes

(2020) Stefano Andrea De Simone et al.   Frontiers in Physiology

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

(2020) Xiaohang Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation

(2020) Viviana Meraviglia et al.   Stem Cell Research

A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties

(2020) Milica Dostanic et al.   JOURNAL OF MICROELECTROMECHANICAL SYSTEMS

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

(2019) Richard J. Mills et al.   Cell Stem Cell

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

(2019) Idit Goldfracht et al.   Acta Biomaterialia

Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform

(2019) Glyn N Stacey et al.   Regenerative Medicine

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

(2019) Hiroyuki Koike et al.   NATURE

Bioreactor-based 3D human myocardial ischemia/reperfusion in vitro model: a novel tool to unveil key paracrine factors upon AMI

(2019) Maria J. Sebastião et al.   Translational Research

Understanding Multicellularity: The Functional Organization of the Intercellular Space

(2019) Leonardo Bich et al.   Frontiers in Physiology

Vascularization of Engineered Spatially Patterned Myocardial Tissue Derived From Human Pluripotent Stem Cells in vivo

(2019) Maureen Wanjare et al.   Frontiers in Bioengineering and Biotechnology

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

(2019) Olya Mastikhina et al.   BIOMATERIALS

Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets

(2019) Shinpei Tsuruyama et al.   Regenerative Therapy

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics?

(2018) Said Assou et al.   STEM CELLS

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload

(2018) Zhen Ma et al.   Nature Biomedical Engineering

Considering sex as a biological variable in preclinical research

(2017) Leah R. Miller et al.   FASEB JOURNAL

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

(2017) Richard J. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Differentiation of TBX18+/WT1+ Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds

(2017) Jianmin Zhao et al.   STEM CELLS AND DEVELOPMENT

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

(2017) Ilya Y. Shadrin et al.   Nature Communications

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)

(2017) Luca Sala et al.   Jove-Journal of Visualized Experiments

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification

(2017) Eugene K. Lee et al.   Stem Cell Reports

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

(2017) Juan Antonio Guadix et al.   Stem Cell Reports

MUSCLEMOTION

(2017) Luca Sala et al.   CIRCULATION RESEARCH

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

(2017) Liudmila Polonchuk et al.   Scientific Reports

Recounting Cardiac Cellular Composition

(2016) Pingzhu Zhou et al.   CIRCULATION RESEARCH

View from the heart: cardiac fibroblasts in development, scarring and regeneration

(2016) Milena B. Furtado et al.   DEVELOPMENT

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

(2016) Stephanie M. Ravenscroft et al.   TOXICOLOGICAL SCIENCES

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

(2016) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Recapitulating Cell–Cell Interactions for Organoid Construction – Are Biomaterials Dispensable?

(2016) Andrew C.A. Wan   TRENDS IN BIOTECHNOLOGY

Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) Josè Manuel Pioner et al.   Stem Cell Reports

Human Engineered Heart Tissue: Analysis of Contractile Force

(2016) Ingra Mannhardt et al.   Stem Cell Reports

Cardiac fibroblast-derived VCAM-1 enhances cardiomyocyte proliferation for fabrication of bioengineered cardiac tissue

(2016) Takahiro Iwamiya et al.   Regenerative Therapy

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses

(2016) Nathaniel Huebsch et al.   Scientific Reports

Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels

(2016) Wendy Keung et al.   Scientific Reports

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?

(2015) Christiaan C. Veerman et al.   STEM CELLS AND DEVELOPMENT

Impact of detubulation on force and kinetics of cardiac muscle contraction

(2014) Cecilia Ferrantini et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue

(2014) Miao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

(2011) Nathaniel L. Tulloch et al.   CIRCULATION RESEARCH

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology

(2011) Sebastian Schaaf et al.   PLoS One

Cell Communications in the Heart

(2010) Daniela Tirziu et al.   CIRCULATION

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epicardium and Myocardium Originate From a Common Cardiogenic Precursor Pool

(2010) Bram van Wijk et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Scaffold-Free Human Cardiac Tissue Patch Created from Embryonic Stem Cells

(2008) Kelly R. Stevens et al.   TISSUE ENGINEERING PART A