Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics?

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

(2017) Florian T. Merkle et al.   NATURE

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

(2016) Noa Lamm et al.   Cell Stem Cell

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Raising the standards of stem cell line quality

(2016) Michael P. Yaffe et al.   NATURE CELL BIOLOGY

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Whole-genome mutational burden analysis of three pluripotency induction methods

(2016) Kunal Bhutani et al.   Nature Communications

Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability

(2016) Kurt Jacobs et al.   Stem Cell Reports

Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells

(2016) Duncan Baker et al.   Stem Cell Reports

Human induced pluripotent stem cells: A disruptive innovation

(2016) J. De Vos et al.   Current Research in Translational Medicine

Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays

(2015) A. C. Y. Mak et al.   GENETICS

Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells

(2015) Amy P Wong et al.   Nature Protocols

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Concise Review: Induced Pluripotency by Defined Factors: Prey of Oxidative Stress

(2015) Suxia Qi et al.   STEM CELLS

Temporal Analysis of Genome Alterations Induced by Single-Cell Passaging in Human Embryonic Stem Cells

(2015) Qiang Bai et al.   STEM CELLS AND DEVELOPMENT

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

(2015) Sergio Ruiz et al.   Nature Communications

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

(2015) Xiao-Hui Zhang et al.   Molecular Therapy-Nucleic Acids

Increased Risk of Genetic and Epigenetic Instability in Human Embryonic Stem Cells Associated with Specific Culture Conditions

(2015) Ibon Garitaonandia et al.   PLoS One

Culture Adaptation Alters Transcriptional Hierarchies among Single Human Embryonic Stem Cells Reflecting Altered Patterns of Differentiation

(2015) Paul J. Gokhale et al.   PLoS One

Replication stress and cancer: It takes two to tango

(2014) Emilio Lecona et al.   EXPERIMENTAL CELL RESEARCH

Guidelines for investigating causality of sequence variants in human disease

(2014) D. G. MacArthur et al.   NATURE

Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges

(2014) Pedro H. Oliveira et al.   STEM CELLS

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells

(2014) Luhan Yang et al.   Nature Communications

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Embryonic Stem Cells or Induced Pluripotent Stem Cells? A DNA Integrity Perspective

(2013) Qiang Bai et al.   CURRENT GENE THERAPY

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

(2013) S. W. Cho et al.   GENOME RESEARCH

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

BCL-XL Mediates the Strong Selective Advantage of a 20q11.21 Amplification Commonly Found in Human Embryonic Stem Cell Cultures

(2013) Stuart Avery et al.   Stem Cell Reports

Standardization of pluripotent stem cell cultures for toxicity testing

(2012) Francesca Pistollato et al.   Expert Opinion on Drug Metabolism & Toxicology

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

(2012) Alexej Abyzov et al.   NATURE

Adapting human pluripotent stem cells to high-throughput and high-content screening

(2012) Sabrina C Desbordes et al.   Nature Protocols

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

(2011) Louise C. Laurent et al.   Cell Stem Cell

Genomic instability in iPS: time for a break

(2011) Maria A Blasco et al.   EMBO JOURNAL

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Copy number variation and selection during reprogramming to pluripotency

(2011) Samer M. Hussein et al.   NATURE

Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells

(2011) Seth M Taapken et al.   NATURE BIOTECHNOLOGY

Recurrent copy number variations in human induced pluripotent stem cells

(2011) Kristen Martins-Taylor et al.   NATURE BIOTECHNOLOGY

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

(2011)   NATURE BIOTECHNOLOGY

Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

(2011) H. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Genomic Stability of Human Induced Pluripotent Stem Cells

(2011) Kristen Martins-Taylor et al.   STEM CELLS

Genetic instability in human induced pluripotent stem cells: Classification of causes and possible safeguards

(2010) Uri Ben-David et al.   CELL CYCLE

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

A Fresh Look at iPS Cells

(2009) Shinya Yamanaka   CELL

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

(2009) Ángel Raya et al.   NATURE

Origins and functional impact of copy number variation in the human genome

(2009) Donald F. Conrad et al.   NATURE

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

(2009) E. P. Papapetrou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human embryonic stem cells and genomic instability

(2009) Nathalie Lefort et al.   Regenerative Medicine

Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes

(2009)   Stem Cell Reviews and Reports

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells

(2008) Nimet Maherali et al.   Cell Stem Cell

Human embryonic stem cells reveal recurrent genomic instability at 20q11.21

(2008) Nathalie Lefort et al.   NATURE BIOTECHNOLOGY

Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

(2008) T. Aoi et al.   SCIENCE