Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome

(2018) Wei Wang et al.   JOURNAL OF NEUROSCIENCE

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

(2018) Wolfgang Dubiel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior

(2017) A C Brumback et al.   MOLECULAR PSYCHIATRY

Kctd13 deletion reduces synaptic transmission via increased RhoA

(2017) Christine Ochoa Escamilla et al.   NATURE

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

(2017) Holly A F Stessman et al.   NATURE GENETICS

Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder

(2017) L A Ajram et al.   Translational Psychiatry

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor

(2016) Colleen A. McGourty et al.   CELL

Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

(2016) Zhen Yan et al.   JOURNAL OF NEUROSCIENCE

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications

(2016) Hsin-Yi Chen et al.   Cell Division

Striatal Circuits as a Common Node for Autism Pathophysiology

(2016) Marc V. Fuccillo   Frontiers in Neuroscience

A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation

(2015) Gonzalo Quassollo et al.   CURRENT BIOLOGY

Striatal circuits, habits, and implications for obsessive–compulsive disorder

(2015) Eric Burguière et al.   CURRENT OPINION IN NEUROBIOLOGY

A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth

(2015) Alessia Peserico et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Spatiotemporal 16p11.2 Protein Network Implicates Cortical Late Mid-Fetal Brain Development and KCTD13-Cul3-RhoA Pathway in Psychiatric Diseases

(2015) Guan Ning Lin et al.   NEURON

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan

(2015) Sungji Ha et al.   Experimental Neurobiology

Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis

(2014) L Tebartz van Elst et al.   MOLECULAR PSYCHIATRY

Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders

(2014) D Schubert et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Neural Signatures of Autism Spectrum Disorders: Insights into Brain Network Dynamics

(2014) Leanna M Hernandez et al.   NEUROPSYCHOPHARMACOLOGY

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism

(2013) Marieke Langen et al.   BIOLOGICAL PSYCHIATRY

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Epigenetic Signatures of Autism

(2011) Hennady P. Shulha   ARCHIVES OF GENERAL PSYCHIATRY

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Microduplications of 16p11.2 are associated with schizophrenia

(2009) Shane E McCarthy et al.   NATURE GENETICS

The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase

(2008) Huaye Zhang et al.   DEVELOPMENTAL CELL

Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons

(2008) Carlos Cepeda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Association between Microdeletion and Microduplication at 16p11.2 and Autism

(2008) Lauren A. Weiss et al.   NEW ENGLAND JOURNAL OF MEDICINE