Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia

Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia

(2017) Meng-Lin Li et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

GSK3β Hyperactivity during an Early Critical Period Impairs Prefrontal Synaptic Plasticity and Induces Lasting Deficits in Spine Morphology and Working Memory

(2016) Bo Xing et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic Basis of Mental Illness

(2016) Eric J. Nestler et al.   NEUROSCIENTIST

Ketamine administration during the second postnatal week induces enduring schizophrenia-like behavioral symptoms and reduces parvalbumin expression in the medial prefrontal cortex of adult mice

(2015) Vivek Jeevakumar et al.   BEHAVIOURAL BRAIN RESEARCH

Schizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology

(2015) C.A. Tamminga et al.   NEUROSCIENCE

NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders

(2015) Sarah A. Monaco et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Regulation of gene transcription by Polycomb proteins

(2015) S. Aranda et al.   Science Advances

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition

(2014) Rahul Bharadwaj et al.   NEURON

DNA methylation changes in the postmortem dorsolateral prefrontal cortex of patients with schizophrenia

(2014) Shusuke Numata et al.   Frontiers in Genetics

Treating Working Memory Deficits in Schizophrenia: A Review of the Neurobiology

(2013) Tristram A. Lett et al.   BIOLOGICAL PSYCHIATRY

Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex

(2013) Marzena Maćkowiak et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Recruitment and Biological Consequences of Histone Modification of H3K27me3 and H3K9me3

(2013) J. Kim et al.   ILAR JOURNAL

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

(2013) Min Wang et al.   NEURON

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

(2013) Melissa A. Snyder et al.   Frontiers in Cellular Neuroscience

Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia

(2012) S Kano et al.   MOLECULAR PSYCHIATRY

Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia

(2012) C S Weickert et al.   MOLECULAR PSYCHIATRY

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

Gestational Methylazoxymethanol Exposure Leads to NMDAR Dysfunction in Hippocampus During Early Development and Lasting Deficits in Learning

(2012) Melissa A Snyder et al.   NEUROPSYCHOPHARMACOLOGY

Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia

(2012) Peilin Jia et al.   PLoS Computational Biology

NMDA receptors, cognition and schizophrenia – Testing the validity of the NMDA receptor hypofunction hypothesis

(2011) Gary Gilmour et al.   NEUROPHARMACOLOGY

The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus

(2011) Eva Hradetzky et al.   NEUROPSYCHOPHARMACOLOGY

Forebrain NR2B Overexpression Facilitating the Prefrontal Cortex Long-Term Potentiation and Enhancing Working Memory Function in Mice

(2011) Yihui Cui et al.   PLoS One

N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?

(2010) Joshua T. Kantrowitz et al.   BRAIN RESEARCH BULLETIN

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

(2010) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

Development of calcium-permeable AMPA receptors and their correlation with NMDA receptors in fast-spiking interneurons of rat prefrontal cortex

(2010) Huai-Xing Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

(2010) Sabine Endele et al.   NATURE GENETICS

Expression of the NR2B-NMDA receptor trafficking complex in prefrontal cortex from a group of elderly patients with schizophrenia

(2010) L.V. Kristiansen et al.   SCHIZOPHRENIA RESEARCH

Gestational methylazoxymethanol acetate administration: A developmental disruption model of schizophrenia

(2009) Daniel J. Lodge et al.   BEHAVIOURAL BRAIN RESEARCH

The molecular pathology of schizophrenia—Focus on histone and DNA modifications

(2009) Schahram Akbarian   BRAIN RESEARCH BULLETIN

Cell Type-Specific Development of NMDA Receptors in the Interneurons of Rat Prefrontal Cortex

(2009) Huai-Xing Wang et al.   NEUROPSYCHOPHARMACOLOGY

Neonatal ventral hippocampus lesions disrupt extra-dimensional shift and alter dendritic spine density in the medial prefrontal cortex of juvenile rats

(2008) Jean-Philippe Marquis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex

(2008) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA