Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity

(2012) T. Kaneko et al.   JOURNAL OF IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

(2012) A. M. Khalil et al.   SCIENCE

Regulation of NF-κB induction by TCR/CD28

(2011) Jing Cheng et al.   IMMUNOLOGIC RESEARCH

The Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1 Is an Intrinsic Central Regulator of Dendritic Cell Function

(2011) Indu R. Ramachandran et al.   JOURNAL OF IMMUNOLOGY

Impact of age on T cell signaling: A general defect or specific alterations?

(2010) Anis Larbi et al.   AGEING RESEARCH REVIEWS

Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes

(2010) Claudine Irles et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells

(2010) Randi Mosenden et al.   CELLULAR SIGNALLING

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Multiple Sclerosis in the Elderly Patient

(2010) Amer Awad et al.   DRUGS & AGING

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis

(2010) Carl F. Fortin et al.   INTERNATIONAL IMMUNOLOGY

Immune Aging and Rheumatoid Arthritis

(2010) Jorg J. Goronzy et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Lck and the nature of the T cell receptor trigger

(2010) Simon J. Davis et al.   TRENDS IN IMMUNOLOGY

Aging and cancer cell biology, 2009

(2009) Judith Campisi et al.   AGING CELL

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45

(2009) A.E. Saunders et al.   CELLULAR SIGNALLING

Immunosenescence: what does it mean to health outcomes in older adults?

(2009) Janet E McElhaney et al.   CURRENT OPINION IN IMMUNOLOGY

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

Mechanisms of costimulation

(2009) Arlene H. Sharpe   IMMUNOLOGICAL REVIEWS

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

Human innate immunosenescence: causes and consequences for immunity in old age

(2009) Alexander Panda et al.   TRENDS IN IMMUNOLOGY