Paradoxical changes in innate immunity in aging: recent progress and new directions

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

(2015) Talibah U. Metcalf et al.   AGING CELL

Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma

(2015) Xiting Yan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Aging and DNA methylation

(2015) Marc Jung et al.   BMC BIOLOGY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

16thIHIW: Immunogenetics of Aging

(2015) E. Naumova et al.   International Journal of Immunogenetics

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

(2014) Jon Hazeldine et al.   AGING CELL

Characterization of age signatures of DNA methylation in normal and cancer tissues from multiple studies

(2014) Jihyun Kim et al.   BMC GENOMICS

Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study

(2014) Juulia Jylhävä et al.   BMC Medical Genomics

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Effect of aging on microRNAs and regulation of pathogen recognition receptors

(2014) Fabiola Olivieri et al.   CURRENT OPINION IN IMMUNOLOGY

Effects of polymorphisms in immunity-related genes on the immune system and successful aging

(2014) Qingwei Ruan et al.   CURRENT OPINION IN IMMUNOLOGY

Expanding roles of neutrophils in aging hosts

(2014) Ching Wen Tseng et al.   CURRENT OPINION IN IMMUNOLOGY

A systems biology approach to the effect of aging, immunosenescence and vaccine response

(2014) Gregory A Poland et al.   CURRENT OPINION IN IMMUNOLOGY

Hematopoietic stem cell aging

(2014) Hartmut Geiger et al.   CURRENT OPINION IN IMMUNOLOGY

B cell function and influenza vaccine responses in healthy aging and disease

(2014) Daniela Frasca et al.   CURRENT OPINION IN IMMUNOLOGY

Aging of the human innate immune system in HIV infection

(2014) Heidi J Zapata et al.   CURRENT OPINION IN IMMUNOLOGY

Epigenetic regulation of hematopoietic stem cell aging

(2014) Isabel Beerman et al.   EXPERIMENTAL CELL RESEARCH

H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

(2014) Agustín F. Fernández et al.   GENOME RESEARCH

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CyTOF supports efficient detection of immune cell subsets from small samples

(2014) Yi Yao et al.   JOURNAL OF IMMUNOLOGICAL METHODS

mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia

(2014) L. Xie et al.   JOURNAL OF IMMUNOLOGY

Prolonged Proinflammatory Cytokine Production in Monocytes Modulated by Interleukin 10 After Influenza Vaccination in Older Adults

(2014) Subhasis Mohanty et al.   JOURNAL OF INFECTIOUS DISEASES

Multiplexed ion beam imaging of human breast tumors

(2014) Michael Angelo et al.   NATURE MEDICINE

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors

(2014) William E. O’Gorman et al.   VACCINE

Age-related variations in the methylome associated with gene expression in human monocytes and T cells

(2014) Lindsay M. Reynolds et al.   Nature Communications

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

(2013) Karel G. M. Beenakker et al.   AGING CELL

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

(2013) Erik B. van den Akker et al.   AGING CELL

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Lipidomics in longevity and healthy aging

(2013) Vanessa Gonzalez-Covarrubias   BIOGERONTOLOGY

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

Changes in Adipose Tissue Macrophages and T Cells During Aging

(2013) Sanjay K. Garg et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

(2013) A. L. Brubaker et al.   JOURNAL OF IMMUNOLOGY

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

(2013) D. Furman et al.   Molecular Systems Biology

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Entering the era of single-cell transcriptomics in biology and medicine

(2013) Rickard Sandberg   NATURE METHODS

Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand

(2013) Ashley M. Fenn et al.   NEUROBIOLOGY OF AGING

Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages

(2013) Viviana Cobos Jiménez et al.   PHYSIOLOGICAL GENOMICS

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

(2013) Sebastiano Collino et al.   PLoS One

Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics

(2013) Collin R. Brooks et al.   RESPIROLOGY

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

(2012) Fabiola Olivieri et al.   AGE

Human serum metabolic profiles are age dependent

(2012) Zhonghao Yu et al.   AGING CELL

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

MicroRNA in Aging: From Discovery to Biology

(2012) Hwa Jin Jung et al.   CURRENT GENOMICS

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin

(2012) H. W. Stout-Delgado et al.   JOURNAL OF IMMUNOLOGY

Age and low levels of circulating vitamin D are associated with impaired innate immune function

(2012) Lorena Alvarez-Rodriguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

TLR7 Recognition Is Dispensable for Influenza Virus A Infection but Important for the Induction of Hemagglutinin-Specific Antibodies in Response to the 2009 Pandemic Split Vaccine in Mice

(2012) V. Jeisy-Scott et al.   JOURNAL OF VIROLOGY

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

(2012) Fabiola Olivieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Innate Immune Dysfunctions in Aged Mice Facilitate the Systemic Dissemination of Methicillin-Resistant S. aureus

(2012) Ching Wen Tseng et al.   PLoS One

Genetics of longevity. Data from the studies on Sicilian centenarians

(2012) Carmela R Balistreri et al.   Immunity & Ageing

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

(2011) Pooja Shivshankar et al.   AGING CELL

Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

(2011) Feng Qian et al.   AGING CELL

Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells

(2011) Yang Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53

(2011) Alejandro P Ugalde et al.   EMBO JOURNAL

Impaired Interferon Signaling in Dendritic Cells From Older Donors Infected In Vitro With West Nile Virus

(2011) Feng Qian et al.   JOURNAL OF INFECTIOUS DISEASES

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Widespread and tissue specific age-related DNA methylation changes in mice

(2010) S. Maegawa et al.   GENOME RESEARCH

Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

(2010) Joseph Nyugen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Highly multiparametric analysis by mass cytometry

(2010) Olga Ornatsky et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

(2009) Ernesto Hinojosa et al.   JOURNAL OF INFECTIOUS DISEASES

Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly

(2008) K.-F. Kong et al.   JOURNAL OF VIROLOGY