Disentangling the Structure–Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Disentangling the Structure–Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs
Authors
Keywords
-
Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 7, Pages 3578-3603
Publisher
American Chemical Society (ACS)
Online
2021-03-23
DOI
10.1021/acs.jmedchem.1c00125
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition
- (2020) Tingting Zou et al. MOLECULES
- Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography
- (2020) Chiara Platella et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology
- (2020) Tam Vo et al. ACS Medicinal Chemistry Letters
- Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models
- (2020) Ahmed A. Ahmed et al. ACS Medicinal Chemistry Letters
- A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells
- (2020) Ahmed Abdullah Ahmed et al. Scientific Reports
- On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model
- (2020) Valentina Pirota et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains
- (2019) Yue Ma et al. MOLECULES
- Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands
- (2019) Valentina Pirota et al. MOLECULES
- Cyclic Naphthalene Diimide Dimer with a Strengthened Ability to Stabilize Dimeric G‐Quadruplex
- (2019) Ryusuke Takeuchi et al. CHEMISTRY-A EUROPEAN JOURNAL
- Dyads of G‐Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration
- (2019) Filippo Doria et al. CHEMISTRY-A EUROPEAN JOURNAL
- Shedding light on the interaction of polydatin and resveratrol with G-quadruplex and duplex DNA: a biophysical, computational and biological approach
- (2019) Chiara Platella et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- The Oncogenic Signaling Pathways in BRAF-Mutant Melanoma Cells are Modulated by Naphthalene Diimide-Like G-Quadruplex Ligands
- (2019) Recagni et al. Cells
- Cyclic Naphthalene Diimide with a Ferrocene Moiety as a Redox‐Active Tetraplex‐DNA Ligand
- (2019) Shuma Kaneyoshi et al. CHEMISTRY-A EUROPEAN JOURNAL
- Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands
- (2018) Chiara Platella et al. ANALYTICA CHIMICA ACTA
- A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line
- (2018) Mekala Gunaratnam et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule
- (2018) Chiara Marchetti et al. JOURNAL OF MEDICINAL CHEMISTRY
- OUP accepted manuscript
- (2018) NUCLEIC ACIDS RESEARCH
- Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells
- (2018) Daniela Muoio et al. FEBS Journal
- Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide
- (2018) Martina Tassinari et al. JOURNAL OF MEDICINAL CHEMISTRY
- Interactions Between Spermine-Derivatized Tentacle Porphyrins and The Human Telomeric DNA G-Quadruplex
- (2018) Navin Sabharwal et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tailoring a lead-like compound targeting multiple G-quadruplex structures
- (2018) Jussara Amato et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains
- (2017) Andrea Milelli et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
- (2017) Hong Xu et al. Nature Communications
- Extended Naphthalene Diimides with Donor/Acceptor Hydrogen-Bonding Properties Targeting G-Quadruplex Nucleic Acids
- (2016) Filippo Doria et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Limits to Personalized Cancer Medicine
- (2016) Ian F. Tannock et al. NEW ENGLAND JOURNAL OF MEDICINE
- A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications
- (2016) Erica Salvati et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Molecular recognition of naphthalene diimide ligands by telomeric quadruplex-DNA: the importance of the protonation state and mediated hydrogen bonds
- (2016) A. Spinello et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer
- (2016) Alessia Lopergolo et al. Oncotarget
- Therapeutic Targeting of Telomerase
- (2016) Kathrin Jäger et al. Genes
- Macrocyclic naphthalene diimides as G-quadruplex binders
- (2015) Chiara Marchetti et al. BIOORGANIC & MEDICINAL CHEMISTRY
- GEMMs as preclinical models for testing pancreatic cancer therapies
- (2015) Aarthi Gopinathan et al. Disease Models & Mechanisms
- Thermodynamics of Binding of Di- and Tetrasubstituted Naphthalene Diimide Ligands to DNA G-Quadruplex
- (2015) Gary Prato et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative
- (2015) Md. Islam et al. MOLECULES
- G-quadruplexes and their regulatory roles in biology
- (2015) Daniela Rhodes et al. NUCLEIC ACIDS RESEARCH
- A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer
- (2015) Stephan A Ohnmacht et al. Scientific Reports
- Interactions of cyclic and non-cyclic naphthalene diimide derivatives with different nucleic acids
- (2014) Izabella Czerwinska et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design of tetraplex specific ligands: cyclic naphthalene diimide
- (2014) Yugo Esaki et al. CHEMICAL COMMUNICATIONS
- Personalised cancer medicine
- (2014) Sarah E. Jackson et al. INTERNATIONAL JOURNAL OF CANCER
- Assessment of gene promoter G-quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells
- (2014) MATTEO NADAI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues
- (2014) Giulia Biffi et al. PLoS One
- The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds
- (2013) Sheila Mpima et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells
- (2013) Marialuisa Micco et al. JOURNAL OF MEDICINAL CHEMISTRY
- G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets
- (2013) Joanna Bidzinska et al. MOLECULES
- Quantitative visualization of DNA G-quadruplex structures in human cells
- (2013) Giulia Biffi et al. Nature Chemistry
- State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders
- (2012) Bruno Pagano et al. CURRENT PHARMACEUTICAL DESIGN
- New insights from molecular dynamic simulation studies of the multiple binding modes of a ligand with G-quadruplex DNA
- (2012) Jin-Qiang Hou et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands
- (2012) Gavin W. Collie et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Water soluble extended naphthalene diimides as pH fluorescent sensors and G-quadruplex ligands
- (2012) Filippo Doria et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures
- (2012) Filippo Doria et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Fluorescence intercalator displacement assay for screening G4 ligands towards a variety of G-quadruplex structures
- (2011) Phong Lan Thao Tran et al. BIOCHIMIE
- Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex
- (2011) Matteo Nadai et al. BIOCHIMIE
- Targeting pancreatic cancer with a G-quadruplex ligand
- (2011) Mekala Gunaratnam et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The application of DNA and RNA G-quadruplexes to therapeutic medicines
- (2011) Gavin W. Collie et al. CHEMICAL SOCIETY REVIEWS
- Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
- (2011) Shankar Balasubramanian et al. NATURE REVIEWS DRUG DISCOVERY
- Targeted therapy of chronic myeloid leukemia
- (2010) Con Sullivan et al. BIOCHEMICAL PHARMACOLOGY
- Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells
- (2010) Sonja M. Hampel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- G-quadruplex nucleic acids as therapeutic targets
- (2009) Shankar Balasubramanian et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer
- (2009) Stephen Neidle FEBS Journal
- Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes
- (2009) Bruno Pagano et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule
- (2009) Mekala Gunaratnam et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands
- (2008) Francisco Cuenca et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes
- (2008) Gary N. Parkinson et al. JOURNAL OF MOLECULAR BIOLOGY
- A hitchhiker's guide to G-quadruplex ligands
- (2007) David Monchaud et al. ORGANIC & BIOMOLECULAR CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started