The application of DNA and RNA G-quadruplexes to therapeutic medicines

Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer

(2011) Daniel Shiu-Hin Chan et al.   BIOCHIMIE

Electrochemical aptasensor based on the dual-amplification of G-quadruplex horseradish peroxidase-mimicking DNAzyme and blocking reagent-horseradish peroxidase

(2011) Yali Yuan et al.   BIOSENSORS & BIOELECTRONICS

Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening

(2011) Armin Benz et al.   CHEMBIOCHEM

Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment

(2011) Liang Xu et al.   CHEMICAL COMMUNICATIONS

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

Synthesis and Binding Studies of Novel Diethynyl-Pyridine Amides with Genomic Promoter DNA G-Quadruplexes

(2011) Jyotirmayee Dash et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selection of G-Quadruplex Folding Topology with LNA-Modified Human Telomeric Sequences in K+Solution

(2011) Devranjan Pradhan et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

(2011) Nancy H. Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

(2010) Yen-An Shieh et al.   ACS Nano

G-Quadruplex-based DNAzyme for colorimetric detection ofcocaine: Using magnetic nanoparticles as the separation and amplification element

(2010) Yan Du et al.   ANALYST

A Robust Electronic Switch Made of Immobilized Duplex/Quadruplex DNA

(2010) Bixia Ge et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Dynamers at the Solid-Liquid Interface: Controlling the Reversible Assembly/Reassembly Process between Two Highly Ordered Supramolecular Guanine Motifs (Angew. Chem. Int. Ed. 11/2010)

(2010) Artur Ciesielski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monomorphic RNA G-Quadruplex and Polymorphic DNA G-Quadruplex Structures Responding to Cellular Environmental Factors

(2010) Dong-Hao Zhang et al.   BIOCHEMISTRY

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

The role of G-quadruplex in RNA metabolism: Involvement of FMRP and FMR2P

(2010) Mireille Melko et al.   BIOCHIMIE

Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA

(2010) Dan Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

(2010) Sonja M. Hampel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nanopatterning the surface with ordered supramolecular architectures of N9-alkylated guanines: STM reveals

(2010) Artur Ciesielski et al.   CHEMICAL COMMUNICATIONS

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

(2010) Caterina Maria Lombardo et al.   CHEMICAL COMMUNICATIONS

Selenium Derivatization of Nucleic Acids for X-Ray Crystal-Structure and Function Studies

(2010) Jia Sheng et al.   CHEMISTRY & BIODIVERSITY

Pyridyl-Substituted Corrole Isomers: Synthesis and their Regulation to G-quadruplex Structures

(2010) Heng Ma et al.   Chemistry-An Asian Journal

Functional nucleic acid nanostructures and DNA machines

(2010) Carsten Teller et al.   CURRENT OPINION IN BIOTECHNOLOGY

Models of macromolecular crowding effects and the need for quantitative comparisons with experiment

(2010) Adrian H Elcock   CURRENT OPINION IN STRUCTURAL BIOLOGY

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

Turning off Transcription of thebcl-2Gene by Stabilizing thebcl-2Promoter Quadruplex with Quindoline Derivatives

(2010) Xiao-Dong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macrocyclic Pyridyl Polyoxazoles: Selective RNA and DNA G-Quadruplex Ligands as Antitumor Agents

(2010) Suzanne G. Rzuczek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular dynamics studies of the 3D structure and planar ligand binding of a quadruplex dimer

(2010) Ming-Hui Li et al.   JOURNAL OF MOLECULAR MODELING

Rational Design of Acridine-Based Ligands with Selectivity for Human Telomeric Quadruplexes

(2010) Silvia Sparapani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrospray Mass Spectrometry of Telomeric RNA (TERRA) Reveals the Formation of Stable Multimeric G-Quadruplex Structures

(2010) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A U-Tetrad Stabilizes Human Telomeric RNA G-Quadruplex Structure

(2010) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coexistence of Two Distinct G-Quadruplex Conformations in the hTERT Promoter

(2010) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3)

(2010) M. Clarke Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle

(2010) Sandro Cosconati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

Fluorescence-based duplex–quadruplex competition test to screen for telomerase RNA quadruplex ligands

(2010) Laurent Lacroix et al.   NUCLEIC ACIDS RESEARCH

Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene

(2010) D. Sun et al.   NUCLEIC ACIDS RESEARCH

RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles

(2010) Melissa A. Mullen et al.   NUCLEIC ACIDS RESEARCH

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids

(2010) Erik B. Pedersen et al.   NUCLEIC ACIDS RESEARCH

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

(2010) Dennis Gomez et al.   NUCLEIC ACIDS RESEARCH

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

(2010) Mridula Nambiar et al.   NUCLEIC ACIDS RESEARCH

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

5'-UTR G-quadruplex structures acting as translational repressors

(2010) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Tetramolecular G-quadruplex formation pathways studied by electrospray mass spectrometry

(2010) F. Rosu et al.   NUCLEIC ACIDS RESEARCH

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures

(2010) Stefano Masiero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

(2010) Anthony Bugaut et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Anti-bovine Prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its β isoform with high affinity

(2010) Kazuyoshi Murakami et al.   Prion

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

(2010) P. H. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERRA transcripts are bound by a complex array of RNA-binding proteins

(2010) Isabel López de Silanes et al.   Nature Communications

Aptamer−DNAzyme Hairpins for Amplified Biosensing

(2009) Carsten Teller et al.   ANALYTICAL CHEMISTRY

Design of a G-Quadruplex Topology through Glycosidic Bond Angles

(2009) Mateus Webba da Silva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click Chemistry for the Identification of G-Quadruplex Structures: Discovery of a DNA-RNA G-Quadruplex

(2009) Yan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology

(2009) Jakob T. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Unusually Stable G-Quadruplex within the 5′-UTR of the MT3 Matrix Metalloproteinase mRNA Represses Translation in Eukaryotic Cells

(2009) Mark J. Morris et al.   BIOCHEMISTRY

Repression of Translation of Human Estrogen Receptor α by G-Quadruplex Formation

(2009) Graham D. Balkwill et al.   BIOCHEMISTRY

Selectivity in Ligand Recognition of G-Quadruplex Loops†

(2009) Nancy H. Campbell et al.   BIOCHEMISTRY

Characterization of a K+-Induced Conformational Switch in a Human Telomeric DNA Oligonucleotide Using 2-Aminopurine Fluorescence

(2009) Robert D. Gray et al.   BIOCHEMISTRY

Predicting and understanding the stability of G-quadruplexes

(2009) Oliver Stegle et al.   BIOINFORMATICS

A comparison of DNA and RNA quadruplex structures and stabilities

(2009) Astrid Joachimi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conformation and thermostability of oligonucleotide d(GGTTGGTGTGGTTGG) containing thiophosphoryl internucleotide bonds at different positions

(2009) Marina Zaitseva et al.   BIOPHYSICAL CHEMISTRY

Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes

(2009) Nicolas Smargiasso et al.   BMC GENOMICS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

(2009) Gavin Collie et al.   CHEMICAL COMMUNICATIONS

Guanosine Hydrogen-Bonded Scaffolds: A New Way to Control the Bottom-Up Realisation of Well-Defined Nanoarchitectures

(2009) Stefano Lena et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nucleic Acid Aptamers Based on the G-Quadruplex Structure: Therapeutic and Diagnostic Potential

(2009) B. Gatto et al.   CURRENT MEDICINAL CHEMISTRY

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Structure of Long Telomeric RNA Transcripts

(2009) Adrian Randall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Recombination Hot Spot in HIV-1 Contains Guanosine Runs That Can Form a G-quartet Structure and Promote Strand Transferin Vitro

(2009) Wen Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial Synthesis of Thrombin-Binding Aptamers Containing iso-Guanine

(2009) Subba Rao Nallagatla et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

pH-Dependent Structures of an i-Motif DNA in Solution

(2009) Kyeong Sik Jin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Differential Biophysical Behavior of Human Telomeric RNA and DNA Quadruplex

(2009) Amit Arora et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A genome-inspired DNA ligand for the affinity capture of insulin and insulin-like growth factor-2

(2009) Junfeng Xiao et al.   JOURNAL OF SEPARATION SCIENCE

Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+Solution

(2009) Herry Martadinata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Persistent, Well-Defined, Monodisperse, π-Conjugated Organic NanoparticlesviaG-Quadruplex Self-Assembly

(2009) David González-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment

(2009) J. Norseen et al.   JOURNAL OF VIROLOGY

MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription

(2009) C. Caslini et al.   MOLECULAR AND CELLULAR BIOLOGY

Selection for the G4 DNA motif at the 5′ end of human genes

(2009) Johanna Eddy et al.   MOLECULAR CARCINOGENESIS

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

Direct visualization of G-quadruplexes in DNA using atomic force microscopy

(2009) Kelly J. Neaves et al.   NUCLEIC ACIDS RESEARCH

Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein

(2009) T. Mashima et al.   NUCLEIC ACIDS RESEARCH

FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure

(2009) Mounia Bensaid et al.   NUCLEIC ACIDS RESEARCH

Predictable suppression of gene expression by 5′-UTR-based RNA quadruplexes

(2009) Kangkan Halder et al.   NUCLEIC ACIDS RESEARCH

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

(2009) Nassima Temime-Smaali et al.   PLoS One

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA

(2009) J. Nandakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of theNRASProto-oncogene†

(2008) Sunita Kumari et al.   BIOCHEMISTRY

Structural Diversity and Extreme Stability of UnimolecularOxytricha novaTelomeric G-Quadruplex†

(2008) Ja Yil Lee et al.   BIOCHEMISTRY

Ligands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders

(2008) D. Monchaud et al.   BIOCHIMIE

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Inhibition of Dicing of Guanosine-Rich shRNAs by Quadruplex-Binding Compounds

(2008) Anja Henn et al.   CHEMBIOCHEM

PlasmodiumTelomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds

(2008) Anne De Cian et al.   CHEMBIOCHEM

G-Quadruplex Formation Interferes with P1 Helix Formation in the RNA Component of Telomerase hTERC

(2008) Julien Gros et al.   CHEMBIOCHEM

Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC

(2008) Pravin S. Shirude et al.   CHEMICAL COMMUNICATIONS

G-quadruplex recognition by bis-indole carboxamides

(2008) Jyotirmayee Dash et al.   CHEMICAL COMMUNICATIONS

Multifunctional G-Quadruplex Aptamers and Their Application to Protein Detection

(2008) Tao Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

Effect of Locked-Nucleic Acid on a Biologically Active G-Quadruplex. A Structure-Activity Relationship of the Thrombin Aptamer

(2008) Laura Bonifacio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Study of binding affinity and selectivity of perylene and coronene derivatives towards duplex and quadruplex DNA by ESI-MS

(2008) Valentina Casagrande et al.   JOURNAL OF MASS SPECTROMETRY

Identification of a New G-Quadruplex Motif in theKRASPromoter and Design of Pyrene-Modified G4-Decoys with Antiproliferative Activity in Pancreatic Cancer Cells

(2008) Susanna Cogoi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Immobilized DNA Switches as Electronic Sensors for Picomolar Detection of Plasma Proteins

(2008) Yu Chuan Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+Solution

(2008) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex DNA Assemblies: Loop Length, Cation Identity, and Multimer Formation†

(2008) Nicolas Smargiasso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

4-Thio-deoxyuridylate-modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growth on subendothelial matrix

(2008) S. MENDELBOUM RAVIV et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents

(2008) D. Sun et al.   MOLECULAR CANCER THERAPEUTICS

The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae

(2008) Brian Luke et al.   MOLECULAR CELL

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

(2008) SunMi L. Palumbo et al.   NUCLEIC ACIDS RESEARCH

Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases

(2008) D. Michalowski et al.   NUCLEIC ACIDS RESEARCH

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer

(2008) Marie-Cécile Didiot et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH

T40214/PEI complex: A potent therapeutics for prostate cancer that targets STAT3 signaling

(2008) Priya Weerasinghe et al.   PROSTATE

Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif

(2008) A. Arora et al.   RNA

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY