Gut microbiota shape B cell in health and disease settings

Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation

(2020) Chao Yang et al.   Cell Host & Microbe

Specific microbiota enhances intestinal IgA levels by inducing TGF‐β in T follicular helper cells of Peyer's patches in mice

(2020) Alexander Beller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell Subsets in Intestinal Immunity and Inflammation

(2020) Tian Sun et al.   JOURNAL OF IMMUNOLOGY

Microbiota-targeted maternal antibodies protect neonates from enteric infection

(2020) Wen Zheng et al.   NATURE

Biodiversity and richness shifts of mucosa-associated gut microbiota with progression of colorectal cancer

(2020) Hong-Wei Pan et al.   RESEARCH IN MICROBIOLOGY

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

(2020) Helia N. Sanchez et al.   Nature Communications

Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses

(2020) Jan Kevin Maerz et al.   Frontiers in Immunology

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Early and Short-Term Interventions in the Gut Microbiota Affects Lupus Severity, Progression, and Treatment in MRL/lpr Mice

(2020) Yun Zhang et al.   Frontiers in Microbiology

Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats

(2020) Chunyue Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development

(2020) J. Stewart New et al.   IMMUNITY

Influence of gut microbiota on mucosal IgA antibody response to the polio vaccine

(2020) Ting Zhao et al.   npj Vaccines

B cells and the microbiota: a missing connection in food allergy

(2020) Evelyn Campbell et al.   Mucosal Immunology

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Selective IgA deficiency in humans is associated with reduced gut microbial diversity

(2019) Silje Fjellgård Jørgensen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

(2019) Joana Torres et al.   GUT

Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43

(2019) Wenjing Yang et al.   JOURNAL OF IMMUNOLOGY

Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

(2019) Sung-Wook Hong et al.   Science Advances

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement

(2019) Maria Carlota Dao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

(2019) Yiyangzi Ma et al.   MOLECULAR MEDICINE

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

(2019) Chih‐Yung Chiu et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

T cell–mediated regulation of the microbiota protects against obesity

(2019) Charisse Petersen et al.   SCIENCE

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

(2019) Chandran Ramakrishna et al.   Nature Communications

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

(2019) Marisa Stebegg et al.   Nature Communications

Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis

(2019) Leyre Mestre et al.   Frontiers in Immunology

Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10–producing regulatory B cells

(2019) Yoshiyuki Mishima et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

(2019) Sunny H. Wong et al.   Nature Reviews Gastroenterology & Hepatology

B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

(2019) Lieselotte SM Kreuk et al.   eLife

Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity

(2019) Xiaohang Long et al.   Nature Microbiology

IgA and the intestinal microbiota: the importance of being specific

(2019) Oliver Pabst et al.   Mucosal Immunology

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

(2019) Helen Luck et al.   Nature Communications

The Plasma Interleukin (IL)-35 Level and Frequency of Circulating IL-35+ Regulatory B Cells are Decreased in a Cohort of Chinese Patients with New-onset Systemic Lupus Erythematosus

(2019) Zhuang Ye et al.   Scientific Reports

IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

(2019) Jason R. Catanzaro et al.   Scientific Reports

Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy

(2019) Ahmed Dawood Mohammed et al.   Frontiers in Immunology

The role of gut microbiota in obesity, diabetes mellitus, and effect of metformin: new insights into old diseases

(2019) Alessia Pascale et al.   CURRENT OPINION IN PHARMACOLOGY

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis

(2018) Joel R. Wilmore et al.   Cell Host & Microbe

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

(2018) Michela Miani et al.   Cell Metabolism

MicroRNAs 15A and 16–1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors

(2018) Ronghua Liu et al.   GASTROENTEROLOGY

Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

(2018) Vrishketan Sethi et al.   GASTROENTEROLOGY

Reassessing B cell contributions in multiple sclerosis

(2018) Rui Li et al.   NATURE IMMUNOLOGY

Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag−/− Mice

(2018) Krysta M. Felix et al.   Frontiers in Cellular and Infection Microbiology

Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy

(2018) Xingming Deng et al.   Frontiers in Microbiology

Modulation of Inflammatory Arthritis in Mice by Gut Microbiota Through Mucosal Inflammation and Autoantibody Generation

(2018) Widian K. Jubair et al.   Arthritis & Rheumatology

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice

(2018) Daniel Triner et al.   GASTROENTEROLOGY

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

(2018) Arnau Vich Vila et al.   Science Translational Medicine

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

The role of the microbiota in infectious diseases

(2018) Josie Libertucci et al.   Nature Microbiology

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals

(2017) Giuliana Magri et al.   IMMUNITY

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development

(2017) Majda Dzidic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

(2017) Gera Goverse et al.   JOURNAL OF IMMUNOLOGY

The regulation of gut mucosal IgA B-cell responses: recent developments

(2017) N Y Lycke et al.   Mucosal Immunology

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

IgA-coatedE. colienriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation

(2017) Monica Viladomiu et al.   Science Translational Medicine

The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option

(2017) Fengli Lv et al.   Oncotarget

Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly

(2017) Hirosuke Sugahara et al.   Frontiers in Microbiology

Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5−/dim B-helper T cell induction

(2017) Toshiki Eri et al.   Scientific Reports

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

(2016) Meghan A. Koch et al.   CELL

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

(2016) Mark R. Charbonneau et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Multiple Curricula for B Cell Developmental Programming

(2016) Ellen V. Rothenberg   IMMUNITY

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens

(2016) Melody Y. Zeng et al.   IMMUNITY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells

(2016) Y Wang et al.   Mucosal Immunology

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

A subpopulation of high IL-21-producing CD4+ T cells in Peyer’s Patches is induced by the microbiota and regulates germinal centers

(2016) Leigh Jones et al.   Scientific Reports

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism

(2016) Lin Chen et al.   EBioMedicine

Role of the Gut Microbiome in Modulating Arthritis Progression in Mice

(2016) Xiaofei Liu et al.   Scientific Reports

Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome

(2015) Kei E. Fujimura et al.   Cell Host & Microbe

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

(2015) Jason L. Kubinak et al.   Cell Host & Microbe

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

(2015) Hana Kozakova et al.   Cellular & Molecular Immunology

The role of toll-like receptors in B-cell development and immunopathogenesis of common variable immunodeficiency

(2015) Laleh Sharifi et al.   Expert Review of Clinical Immunology

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

(2015) Jun Yu et al.   GUT

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

(2015) Y Jung et al.   Mucosal Immunology

New insights into gastrointestinal anthrax infection

(2015) Jennifer L. Owen et al.   TRENDS IN MOLECULAR MEDICINE

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Impaired Colonic B-Cell Responses by Gastrointestinal Bacillus anthracis Infection

(2014) Bikash Sahay et al.   JOURNAL OF INFECTIOUS DISEASES

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

(2014) Elizabeth C Rosser et al.   NATURE MEDICINE

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Enteric bacteria promote human and mouse norovirus infection of B cells

(2014) M. K. Jones et al.   SCIENCE

A role for gut-associated lymphoid tissue in shaping the human B cell repertoire

(2013) Anna Vossenkämper et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbial colonization influences early B-lineage development in the gut lamina propria

(2013) Duane R. Wesemann et al.   NATURE

B-1 B Cell Development in the Fetus and Adult

(2012) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

Infant B Cell Memory Differentiation and Early Gut Bacterial Colonization

(2012) A.-C. Lundell et al.   JOURNAL OF IMMUNOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Human milk glycobiome and its impact on the infant gastrointestinal microbiota

(2010) A. M. Zivkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Signaling and Fate Decision

(2009) Tomohiro Kurosaki et al.   Annual Review of Immunology

Dietary Cycloinulooligosaccharides Enhance Intestinal Immunoglobulin A Production in Mice

(2009) Tomomi ISHIKAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY