Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10–producing regulatory B cells

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

(2019) Graham J. Britton et al.   IMMUNITY

The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease

(2018) Katharine G. Harris et al.   CLINICAL SCIENCE

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

(2018) Leonie Brockmann et al.   Nature Communications

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

(2017) R. Balfour Sartor et al.   GASTROENTEROLOGY

Circulating and Tissue-Resident CD4 + T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

(2017) Ahmed N. Hegazy et al.   GASTROENTEROLOGY

Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling

(2016) Cong Wu et al.   IMMUNOLOGY

The expanding family of regulatory B cells

(2015) Claudia Mauri et al.   INTERNATIONAL IMMUNOLOGY

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

(2015) B-H Yang et al.   Mucosal Immunology

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Induction of Bacterial Antigen-Specific Colitis by a Simplified Human Microbiota Consortium in Gnotobiotic Interleukin-10-/- Mice

(2014) C. S. Eun et al.   INFECTION AND IMMUNITY

Innate PI3K p110  Regulates Th1/Th17 Development and Microbiota-Dependent Colitis

(2014) E. C. Steinbach et al.   JOURNAL OF IMMUNOLOGY

Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

(2014) Elizabeth C Rosser et al.   NATURE MEDICINE

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN- +CD4+ T Cell Numbers during Colitis Development in Mice

(2013) D. Maseda et al.   JOURNAL OF IMMUNOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage

(2012) Donna Kirkland et al.   IMMUNITY

Intracellular IL-10 detection in T cells by flowcytometry: The use of protein transport inhibitors revisited

(2012) Anne-Hilde Muris et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

(2012) Seong Gyu Jeon et al.   PLoS Pathogens

Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice

(2011) Bo Liu et al.   GASTROENTEROLOGY

Transient TLR Activation Restores Inflammatory Response and Ability To Control Pulmonary Bacterial Infection in Germfree Mice

(2011) C. T. Fagundes et al.   JOURNAL OF IMMUNOLOGY

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

(2011) M. Mohamadzadeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

An imbalance in mucosal cytokine profile causes transient intestinal inflammation following an animal's first exposure to faecal bacteria and antigens

(2010) B. C. Sydora et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells

(2010) YanMei Liang et al.   CLINICAL IMMUNOLOGY

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Decreased production of interleukin-10 and transforming growth factor-β in Toll-like receptor-activated intestinal B cells in SAMP1/Yit mice

(2010) Yoshiyuki Mishima et al.   IMMUNOLOGY

Toll-Like Receptor 2- and MyD88-Dependent Phosphatidylinositol 3-Kinase and Rac1 Activation Facilitates the Phagocytosis of Listeria monocytogenes by Murine Macrophages

(2010) Y. Shen et al.   INFECTION AND IMMUNITY

TLR-2-Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells

(2010) A. Sayi et al.   JOURNAL OF IMMUNOLOGY

Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn’s disease

(2009) D. K. AMRE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

(2009) R. Madan et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease

(2008) D. E. Fassi et al.   GUT

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS