IgA and the intestinal microbiota: the importance of being specific

Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies

(2019) Alan Shaw et al.   Nature Nanotechnology

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

(2019) Shinji Saito et al.   PLoS Pathogens

BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer’s patches

(2019) Adi Biram et al.   NATURE IMMUNOLOGY

B Cell Responses: Cell Interaction Dynamics and Decisions

(2019) Jason G. Cyster et al.   CELL

Adaptive Evolution within Gut Microbiomes of Healthy People

(2019) Shijie Zhao et al.   Cell Host & Microbe

Enchained growth and cluster dislocation: A possible mechanism for microbiota homeostasis

(2019) Florence Bansept et al.   PLoS Computational Biology

Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model

(2019) Bryan B. Hsu et al.   Cell Host & Microbe

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

(2019) Justina Briliūtė et al.   Nature Microbiology

Therapeutic monoclonal antibody N-glycosylation – Structure, function and therapeutic potential

(2018) Florian Cymer et al.   BIOLOGICALS

Microbial symbionts regulate the primary Ig repertoire

(2018) Yuezhou Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen

(2018) Tim Rollenske et al.   NATURE IMMUNOLOGY

Recent advances in the physiopathology of IgA nephropathy

(2018) Renato C. Monteiro   Nephrologie & Therapeutique

Diversity-Generating Machines: Genetics of Bacterial Sugar-Coating

(2018) Rafał J. Mostowy et al.   TRENDS IN MICROBIOLOGY

IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria

(2018) Akira Nakajima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The regulation of gut mucosal IgA B-cell responses: recent developments

(2017) N Y Lycke et al.   Mucosal Immunology

High-avidity IgA protects the intestine by enchaining growing bacteria

(2017) Kathrin Moor et al.   NATURE

Natural polyreactive IgA antibodies coat the intestinal microbiota

(2017) Jeffrey J. Bunker et al.   SCIENCE

Inflammation boosts bacteriophage transfer between Salmonella spp.

(2017) Médéric Diard et al.   SCIENCE

Defining Natural Antibodies

(2017) Nichol E. Holodick et al.   Frontiers in Immunology

Mouse and Human Liver Contain Immunoglobulin A–Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens

(2016) Ludovic Moro-Sibilot et al.   GASTROENTEROLOGY

Catch-bond mechanism of the bacterial adhesin FimH

(2016) Maximilian M. Sauer et al.   Nature Communications

The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

(2016) Beth M Stadtmueller et al.   eLife

Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species

(2016) Kathrin Moor et al.   Frontiers in Immunology

Antimicrobial Defense of the Intestine

(2015) Sohini Mukherjee et al.   IMMUNITY

Site-Specific Glycosylation of Secretory Immunoglobulin A from Human Colostrum

(2015) Jincui Huang et al.   JOURNAL OF PROTEOME RESEARCH

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Antibiotic-Driven Dysbiosis Mediates Intraluminal Agglutination and Alternative Segregation of Enterococcus faecium from the Intestinal Epithelium

(2015) A. P. A. Hendrickx et al.   mBio

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Segmented Filamentous Bacterium Uses Secondary and Tertiary Lymphoid Tissues to Induce Gut IgA and Specific T Helper 17 Cell Responses

(2014) Emelyne Lécuyer et al.   IMMUNITY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism

(2014) Michele Proietti et al.   IMMUNITY

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

(2014) E. W. Rogier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections

(2014) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine

(2012) Cornelia Lindner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal and affinity-matured gut IgA responses

(2012) P Bergqvist et al.   Mucosal Immunology

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

(2012) S. Kawamoto et al.   SCIENCE

The Human Intestinal IgA Response; Burning Questions

(2012) Jo Spencer et al.   Frontiers in Immunology

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

Structure and function relationships in IgA

(2011) J M Woof et al.   Mucosal Immunology

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

(2011) Min Wei et al.   NATURE IMMUNOLOGY

IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans

(2010) Francesca Barone et al.   GASTROENTEROLOGY

Gut inflammation provides a respiratory electron acceptor for Salmonella

(2010) Sebastian E. Winter et al.   NATURE

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

(2010) Kathrin Endt et al.   PLoS Pathogens

O-linked oligosaccharides of the IgA1 hinge region: roles of its aberrant structure in the occurrence and/or progression of IgA nephropathy

(2009) Yoshiyuki Hiki   Clinical and Experimental Nephrology

Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces

(2009) Jiri Mestecky et al.   IMMUNOLOGY LETTERS

Mucosal Immunity: Induction, Dissemination, and Effector Functions

(2009) P. Brandtzaeg   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

T cell–independent development and induction of somatic hypermutation in human IgM+IgD+CD27+B cells

(2008) Ferenc A. Scheeren et al.   JOURNAL OF EXPERIMENTAL MEDICINE