B cells and the microbiota: a missing connection in food allergy

Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation

(2020) Chao Yang et al.   Cell Host & Microbe

Epidemiology and Burden of Food Allergy

(2020) Christopher M. Warren et al.   CURRENT ALLERGY AND ASTHMA REPORTS

The Role of Lung and Gut Microbiota in the Pathology of Asthma

(2020) Weronika Barcik et al.   IMMUNITY

TLR5 Activation Exacerbates Airway Inflammation in Asthma

(2020) G. S. Whitehead et al.   LUNG

Structure of the secretory immunoglobulin A core

(2020) Nikit Kumar et al.   SCIENCE

Origins of peanut allergy-causing antibodies

(2020) Duane R. Wesemann et al.   SCIENCE

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

(2020) Helia N. Sanchez et al.   Nature Communications

Using Precisely Defined in vivo Microbiotas to Understand Microbial Regulation of IgE

(2020) Madeleine Wyss et al.   Frontiers in Immunology

Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses

(2020) Jan Kevin Maerz et al.   Frontiers in Immunology

Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy

(2020) Ramona A. Hoh et al.   Science Immunology

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Sialylation of immunoglobulin E is a determinant of allergic pathogenicity

(2020) Kai-Ting C. Shade et al.   NATURE

Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization

(2020) Biyan Zhang et al.   Science Immunology

Update on IgG4-mediated autoimmune diseases: New insights and new family members

(2020) Inga Koneczny   AUTOIMMUNITY REVIEWS

Healthy infants harbor intestinal bacteria that protect against food allergy

(2019) Taylor Feehley et al.   NATURE MEDICINE

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

(2019) Michele Proietti et al.   Nature Communications

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

(2019) Ziad Al Nabhani et al.   IMMUNITY

The Microbiome and Food Allergy

(2019) Onyinye I. Iweala et al.   Annual Review of Immunology

Clinical and Laboratory Features of 184 Italian Pediatric Patients Affected with Selective IgA Deficiency (SIgAD): a Longitudinal Single-Center Study

(2019) Vassilios Lougaris et al.   JOURNAL OF CLINICAL IMMUNOLOGY

PD-1-expressing B cells suppress CD4+ and CD8+ T cells via PD-1/PD-L1-dependent pathway

(2019) Xufu Wang et al.   MOLECULAR IMMUNOLOGY

Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

(2019) Sung-Wook Hong et al.   Science Advances

Individually dosed omalizumab facilitates peanut oral immunotherapy in peanut allergic adolescents

(2019) Josef Brandström et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy

(2019) Rita Nocerino et al.   JOURNAL OF PEDIATRICS

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

(2019) Azza Abdel-Gadir et al.   NATURE MEDICINE

Detection of serum and salivary IgE and IgG1 immunoglobulins specific for diagnosis of food allergy

(2019) Marília Porto Oliveira Nunes et al.   PLoS One

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

(2019) Friederike Jönsson et al.   Science Translational Medicine

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1

(2019) Cynthia M. Fehres et al.   Frontiers in Immunology

Critical roles of regulatory B and T cells in helminth parasite‐induced protection against allergic airway inflammation

(2019) X. Gao et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10–producing regulatory B cells

(2019) Yoshiyuki Mishima et al.   JOURNAL OF CLINICAL INVESTIGATION

IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

(2019) Jason R. Catanzaro et al.   Scientific Reports

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Dietary Antigens Induce Germinal Center Responses in Peyer's Patches and Antigen-Specific IgA Production

(2019) Satoko Hara et al.   Frontiers in Immunology

Early-life gut microbiome and egg allergy

(2018) M. Fazlollahi et al.   ALLERGY

IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis

(2018) J. J. Heeringa et al.   ALLERGY

IgA Function in Relation to the Intestinal Microbiota

(2018) Andrew J. Macpherson et al.   Annual Review of Immunology

Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota

(2018) Carolina Tropini et al.   CELL

How to diagnose food allergy

(2018) Sakura Sato et al.   Current Opinion in Allergy and Clinical Immunology

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management

(2018) Scott H. Sicherer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy

(2018) M.Cecilia Berin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of food allergy

(2018) Hugh A. Sampson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes

(2018) Xi Shen et al.   Mucosal Immunology

The impact of a helminth-modified microbiome on host immunity

(2018) Tara P. Brosschot et al.   Mucosal Immunology

Microbial ecology perturbation in human IgA deficiency

(2018) Jehane Fadlallah et al.   Science Translational Medicine

The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

(2018) Holly Turula et al.   Viruses-Basel

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

(2018) J. M. Orengo et al.   Nature Communications

Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses

(2018) Stefan Schülke   Frontiers in Immunology

Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

(2018) Gina-Maria Lilienthal et al.   Frontiers in Immunology

The soluble isoform of human FcɛRI is an endogenous inhibitor of IgE-mediated mast cell responses

(2018) Sherezade Moñino-Romero et al.   ALLERGY

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

(2018) April E. Price et al.   IMMUNITY

IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria

(2018) Akira Nakajima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity

(2018) Hyeseon Cho et al.   Mucosal Immunology

The Effect of Digestion and Digestibility on Allergenicity of Food

(2018) Isabella Pali-Schöll et al.   Nutrients

Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies

(2018) Amanda J. Stranks et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development

(2018) Yong-Soo Lee et al.   Cell Host & Microbe

Ratios of specific IgG4 over IgE antibodies do not improve prediction of peanut allergy nor of its severity compared to specific IgE alone

(2018) Mareen R. Datema et al.   CLINICAL AND EXPERIMENTAL ALLERGY

IgE-Mediated Food Allergy

(2018) Sara Anvari et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles

(2018) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review

(2018) Petra Zimmermann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different flavors of IL-21 in regulation of intestinal IgA to commensals

(2018) Yingzi Cong et al.   Mucosal Immunology

Peanut oral immunotherapy increases IgG4 to Ara h 1, 2, and 6 but does not affect IgG4 to other allergens

(2018) Riikka Uotila et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States

(2018) Ruchi S. Gupta et al.   PEDIATRICS

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin

(2018) Adriana Flores-Langarica et al.   Frontiers in Immunology

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

(2017) Nicola L. Harris et al.   IMMUNITY

Therapeutic reversal of food allergen sensitivity by mature retinoic acid–differentiated dendritic cell induction of LAG3 + CD49b − Foxp3 − regulatory T cells

(2017) Wojciech Dawicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience

(2017) Bradley E. Chipps et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development

(2017) Majda Dzidic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The pathophysiology of anaphylaxis

(2017) Laurent L. Reber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antibody-encoding repertoires of bone marrow and peripheral blood—a focus on IgE

(2017) Mattias Levin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High-avidity IgA protects the intestine by enchaining growing bacteria

(2017) Kathrin Moor et al.   NATURE

Extensively hydrolyzed casein formula alone or with L. rhamnosus GG reduces β-lactoglobulin sensitization in mice

(2017) Rosita Aitoro et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Natural polyreactive IgA antibodies coat the intestinal microbiota

(2017) Jeffrey J. Bunker et al.   SCIENCE

IgA-coatedE. colienriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation

(2017) Monica Viladomiu et al.   Science Translational Medicine

IgG1 memory B cells keep the memory of IgE responses

(2017) Jin-Shu He et al.   Nature Communications

Ana o 3-specific IgE is a good predictor for clinically relevant cashew allergy in children

(2016) L. Lange et al.   ALLERGY

Immunoglobulin E, what is it good for?

(2016) Brian T. Kelly et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease

(2016) Duane R. Wesemann et al.   IMMUNITY

Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells

(2016) Jae-Uoong Shim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase–Akt pathway activation

(2016) Takashi Matsushita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of the host immune system by helminth parasites

(2016) Rick M. Maizels et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human IgE-independent systemic anaphylaxis

(2016) Fred D. Finkelman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human B-cell isotype switching origins of IgE

(2016) Timothy J. Looney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells

(2016) Y Wang et al.   Mucosal Immunology

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow’s milk casein-induced allergic responses in mice

(2016) A-Ram Kim et al.   Scientific Reports

A regulatory CD9+B-cell subset inhibits HDM-induced allergic airway inflammation

(2015) F. Braza et al.   ALLERGY

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

(2015) Hana Kozakova et al.   Cellular & Molecular Immunology

Food Allergies: The Basics

(2015) Rudolf Valenta et al.   GASTROENTEROLOGY

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

Food Allergy

(2015) Jessica Savage et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

(2015) Roberto Berni Canani et al.   ISME Journal

Thrombospondin-1 (TSP1)-producing B Cells Restore Antigen (Ag)-specific Immune Tolerance in an Allergic Environment

(2015) Gui Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children

(2014) K. Beyer et al.   ALLERGY

B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses

(2014) Egest J. Pone et al.   AUTOIMMUNITY

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity

(2014) Oliver T. Burton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunoglobulin A and immunoglobulin G antibodies against β-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6

(2014) Laura Orivuori et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

(2014) E. W. Rogier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal bacteria protect against food allergen sensitization

(2014) A. T. Stefka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerogenic CX3CR1+B cells suppress food allergy-induced intestinal inflammation in mice

(2013) Z.-Q. Liu et al.   ALLERGY

Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

(2013) Julia Cahenzli et al.   Cell Host & Microbe

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Egg-white-specific IgA and IgA2 antibodies in egg-allergic children: Is there a role in tolerance induction?

(2013) George N. Konstantinou et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

(2012) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis

(2012) Magali Noval Rivas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sequential class switching is required for the generation of high affinity IgE antibodies

(2012) Huizhong Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab

(2012) D Bedoret et al.   Mucosal Immunology

Chlamydia pneumoniae-Specific IgE Is Prevalent in Asthma and Is Associated with Disease Severity

(2012) David L. Hahn et al.   PLoS One

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

(2012) Egest J. Pone et al.   Nature Communications

Clinical Utility of IgE Antibodies to ω-5 Gliadin in the Diagnosis of Wheat Allergy: A Pediatric Multicenter Challenge Study

(2011) Motohiro Ebisawa et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy

(2011) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recognition of Gram-positive Intestinal Bacteria by Hybridoma- and Colostrum-derived Secretory Immunoglobulin A Is Mediated by Carbohydrates

(2011) Amandine Mathias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

(2011) Duane R. Wesemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis

(2011) M. V. Khodoun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

(2010) L. Van Maele et al.   JOURNAL OF IMMUNOLOGY

Differential regulation of TLR4 expression in human B cells and monocytes

(2010) Lisa M. Ganley-Leal et al.   MOLECULAR IMMUNOLOGY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

IgA Deficiency: Correlation Between Clinical and Immunological Phenotypes

(2008) Asghar Aghamohammadi et al.   JOURNAL OF CLINICAL IMMUNOLOGY