K27‐linked noncanonic ubiquitination in immune regulation

TRIM26 is a critical host factor for HCV replication and contributes to host tropism

(2021) Yisha Liang et al.   Science Advances

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

(2021) Yan Zeng et al.   PLoS Pathogens

Emerging Roles and Research Tools of Atypical Ubiquitination

(2020) Qiuling Huang et al.   PROTEOMICS

The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response

(2020) Mariska van Huizen et al.   Frontiers in Cell and Developmental Biology

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression

(2020) Yaoxing Wu et al.   Autophagy

Proteasomal degradation of nonstructural protein 12 by RNF114 suppresses porcine reproductive and respiratory syndrome virus replication

(2020) Yuanzhe Bai et al.   VETERINARY MICROBIOLOGY

HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection

(2020) Yu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7

(2020) Zhi Li et al.   JOURNAL OF IMMUNOLOGY

E3 Ubiquitin Ligase RNF114 Inhibits Innate Immune Response to Red-Spotted Grouper Nervous Necrosis Virus Infection in Sea Perch by Targeting MAVS and TRAF3 to Mediate Their Degradation

(2020) Yangxi Xiang et al.   JOURNAL OF IMMUNOLOGY

Linear ubiquitination at a glance

(2019) Maureen Spit et al.   JOURNAL OF CELL SCIENCE

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

(2019) Jonathan J. Cho et al.   Nature Communications

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1

(2019) Cao-Qi Lei et al.   JOURNAL OF IMMUNOLOGY

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

(2019) Qing Yin et al.   Nature Communications

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

(2019) Xin Wu et al.   Nature Communications

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells

(2018) Najla El-Hachem et al.   CELL DEATH AND DIFFERENTIATION

TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis

(2018) Ramesh Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR

(2018) Daisuke Aki et al.   NATURE IMMUNOLOGY

Bartonella quintana type IV secretion effector BepE ‐induced selective autophagy by conjugation with K63 polyubiquitin chain

(2018) Chunyan Wang et al.   CELLULAR MICROBIOLOGY

The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

(2018) Swarupa Panda et al.   Nature Communications

TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production

(2018) Hui Liu et al.   Frontiers in Immunology

Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals

(2017) Mallenahally Kusha Vidya et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation

(2017) Yunfei Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endoplasmic Reticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing Its K27-Linked Polyubiquitylation

(2017) Heng Liu et al.   JOURNAL OF VIROLOGY

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

(2017) Shouheng Jin et al.   MOLECULAR CELL

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

(2017) Martin A. Michel et al.   MOLECULAR CELL

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

USP13 negatively regulates antiviral responses by deubiquitinating STING

(2017) He Sun et al.   Nature Communications

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

(2017) Qiang Wang et al.   PLoS Pathogens

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis

(2016) Man Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins

(2016) Carlos A. Castañeda et al.   STRUCTURE

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

(2016) Frederick C. Nucifora et al.   Nature Communications

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

USP8 and PARK2/parkin-mediated mitophagy

(2015) Thomas M Durcan et al.   Autophagy

HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion

(2015) Vivek Reddy Palicharla et al.   CELLULAR SIGNALLING

Protein monoubiquitylation: targets and diverse functions

(2015) Tadashi Nakagawa et al.   GENES TO CELLS

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

Quantifying Ubiquitin Signaling

(2015) Alban Ordureau et al.   MOLECULAR CELL

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

Ubiquitination in the antiviral immune response

(2015) Meredith E. Davis et al.   VIROLOGY

PRRs are watching you: Localization of innate sensing and signaling regulators

(2015) Jonathan Chow et al.   VIROLOGY

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

(2015) Yong Ran et al.   Journal of Molecular Cell Biology

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

(2015) Peng Wang et al.   PLoS Pathogens

A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

(2014) Sky W. Brubaker et al.   CELL

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

(2014) Juan Liu et al.   NATURE IMMUNOLOGY

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

STUB1 is essential for T-cell activation by ubiquitinating CARMA1

(2013) Shuai Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia

(2012) Tian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway

(2012) Weiming Xu et al.   MOLECULES

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

(2011) S Mehdi Belgnaoui et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Noncanonical K27-Linked Polyubiquitination of TIEG1 Regulates Foxp3 Expression and Tumor Growth

(2011) D.-J. Peng et al.   JOURNAL OF IMMUNOLOGY

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

(2011) Marissa L. Matsumoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains

(2010) Silvia Zucchelli et al.   HUMAN MOLECULAR GENETICS

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

(2010) K.-i. Arimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS