Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7

Noncanonical Role of FBXO6 in Regulating Antiviral Immunity

(2019) Xiaohong Du et al.   JOURNAL OF IMMUNOLOGY

Neddylation Facilitates the Antiviral Response in Zebrafish

(2019) Guangqing Yu et al.   Frontiers in Immunology

Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid‐inducible gene‐I‐like receptor signaling

(2019) Junji Zhu et al.   FASEB JOURNAL

TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS

(2018) Binbin Xue et al.   JOURNAL OF VIROLOGY

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7

(2018) Long-Feng Lu et al.   JOURNAL OF IMMUNOLOGY

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

(2017) Shafi Kuchay et al.   NATURE

Post-translational Control of Intracellular Pathogen Sensing Pathways

(2017) Cindy Chiang et al.   TRENDS IN IMMUNOLOGY

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

(2017) Qiang Wang et al.   PLoS Pathogens

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

(2016) Jie Li et al.   Cellular & Molecular Immunology

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator)

(2016) Wei Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zebrafishfoxo3bNegatively Regulates Antiviral Response through Suppressing the Transactivity ofirf3andirf7

(2016) Xing Liu et al.   JOURNAL OF IMMUNOLOGY

Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes

(2016) Hui Feng et al.   JOURNAL OF IMMUNOLOGY

A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation

(2016) Di Peng et al.   JOURNAL OF IMMUNOLOGY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response

(2016) Zhou Yu et al.   eLife

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity

(2015) Zhichao Mei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ELL Protein-associated Factor 2 (EAF2) Inhibits Transforming Growth Factor β Signaling through a Direct Interaction with Smad3

(2015) Xing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin in the activation and attenuation of innate antiviral immunity

(2015) Steven M. Heaton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation

(2015) Juan Du et al.   JOURNAL OF IMMUNOLOGY

Response of host inflammasomes to viral infection

(2015) I-Yin Chen et al.   TRENDS IN MICROBIOLOGY

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

The Von Hippel-Lindau Protein Suppresses Androgen Receptor Activity

(2014) Jing Wang et al.   MOLECULAR ENDOCRINOLOGY

Unconventional post-translational modifications in immunological signaling

(2014) Kerri A Mowen et al.   NATURE IMMUNOLOGY

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

(2014) Juan Liu et al.   NATURE IMMUNOLOGY

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation

(2013) R. K. Mallampalli et al.   JOURNAL OF IMMUNOLOGY

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

(2013) Bill B Chen et al.   NATURE IMMUNOLOGY

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I

(2012) Stéphane Biacchesi et al.   PLoS One

Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7

(2011) F. Sun et al.   JOURNAL OF IMMUNOLOGY

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

(2011) Shanshan Duan et al.   NATURE

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

(2010) K.-i. Arimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Antiviral Signaling Protein Plays a Major Role in Induction of the Fish Innate Immune Response against RNA and DNA Viruses

(2009) S. Biacchesi et al.   JOURNAL OF VIROLOGY

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

(2009) Manas K. Santra et al.   NATURE

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS