Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1

(2019) Cao-Qi Lei et al.   JOURNAL OF IMMUNOLOGY

The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

(2018) Igor Kovačević et al.   JOURNAL OF CELL BIOLOGY

The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice

(2018) Erin S. Coyne et al.   DIABETOLOGIA

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

(2017) Qing Yang et al.   PLoS Pathogens

The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses

(2016) Jun Cui et al.   Autophagy

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1

(2016) Shouheng Jin et al.   EMBO JOURNAL

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells

(2016) Jin-Gu Lee et al.   NATURE CELL BIOLOGY

WDFY1 mediates TLR3/4 signaling by recruiting TRIF

(2015) Y.-H. Hu et al.   EMBO REPORTS

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting

(2015) Nathalie Bédard et al.   FASEB JOURNAL

Female-specific regulation of skeletal muscle mass by USP19 in young mice

(2015) M. Ogawa et al.   JOURNAL OF ENDOCRINOLOGY

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

(2015) Ming-Ming Hu et al.   JOURNAL OF IMMUNOLOGY

USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling

(2015) Benjamin Wiles et al.   MOLECULAR BIOLOGY OF THE CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

(2013) Y. Enokizono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia

(2011) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells

(2011) Yu Lu et al.   PLoS One

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

(2009) Gerco C Hassink et al.   EMBO REPORTS

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY