Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy
Authors
Keywords
Immune checkpoint blockade, Immunotherapy, Tumor microenvironment, Targeted nanomedicine delivery, Combination therapy
Journal
JOURNAL OF CONTROLLED RELEASE
Volume 332, Issue -, Pages 109-126
Publisher
Elsevier BV
Online
2021-02-09
DOI
10.1016/j.jconrel.2021.02.002
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model
- (2020) Huan Xu et al. BIOMATERIALS
- Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial
- (2020) Michael R Migden et al. LANCET ONCOLOGY
- Engineering Targeting Materials for Therapeutic Cancer Vaccines
- (2020) Priscilla S. Briquez et al. Frontiers in Bioengineering and Biotechnology
- Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration
- (2020) Monica Agnoletti et al. ACS Nano
- Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives
- (2020) Stefania Raimondo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy
- (2020) Man Li et al. JOURNAL OF CONTROLLED RELEASE
- Myeloid Cell-Derived Arginase in Cancer Immune Response
- (2020) Tomasz M. Grzywa et al. Frontiers in Immunology
- Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial
- (2020) Sandra P D'Angelo et al. Journal for ImmunoTherapy of Cancer
- Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts
- (2020) Laura Santana-Viera et al. Cancers
- Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275
- (2020) Matthew D. Galsky et al. CLINICAL CANCER RESEARCH
- Heme Oxygenase 1‐Targeted Hybrid Nanoparticle for Chemo‐ and Immuno‐Combination Therapy in Acute Myelogenous Leukemia
- (2020) Seok‐Beom Yong et al. Advanced Science
- Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance
- (2020) Patrick Santos et al. Cells
- KEYNOTE-013 4-year follow-up of pembrolizumab in classical Hodgkin lymphoma after brentuximab vedotin failure
- (2020) Philippe Armand et al. Blood Advances
- Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery
- (2020) Binfan Chen et al. BIOMATERIALS
- Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy
- (2020) Nour Shobaki et al. JOURNAL OF CONTROLLED RELEASE
- Enhancement of tumour penetration by nanomedicines through strategies based on transport processes and barriers
- (2020) Huang Yang et al. JOURNAL OF CONTROLLED RELEASE
- Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
- (2019) Daniel Shae et al. Nature Nanotechnology
- Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
- (2019) Nicola Ferrari et al. Nature Communications
- Powerful Anticolon Tumor Effect of Targeted Gene Immunotherapy Using Folate-Modified Nanoparticle Delivery of CCL19 To Activate the Immune System
- (2019) Xiaoxiao Liu et al. ACS Central Science
- Dynamic Targeting in Cancer Treatment
- (2019) Zhihui Wang et al. Frontiers in Physiology
- Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs
- (2019) Betul Gok Yavuz et al. Scientific Reports
- Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
- (2019) Brian I. Rini et al. NEW ENGLAND JOURNAL OF MEDICINE
- Exosomes in the tumor microenvironment as mediators of cancer therapy resistance
- (2019) Irene Li et al. Molecular Cancer
- Primary Results from SAUL, a Multinational Single-arm Safety Study of Atezolizumab Therapy for Locally Advanced or Metastatic Urothelial or Nonurothelial Carcinoma of the Urinary Tract
- (2019) Cora N. Sternberg et al. EUROPEAN UROLOGY
- Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer
- (2019) Hairong Wang et al. ADVANCED FUNCTIONAL MATERIALS
- Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry
- (2019) J Mazières et al. ANNALS OF ONCOLOGY
- Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
- (2019) Mauro Poggio et al. CELL
- Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy
- (2019) Xinlong Zang et al. MOLECULAR PHARMACEUTICS
- Targeting Tumor-Associated Macrophages in Cancer
- (2019) Paulina Pathria et al. TRENDS IN IMMUNOLOGY
- Neutrophil–lymphocyte ratio (NLR) predicted prognosis for advanced non-small-cell lung cancer (NSCLC) patients who received immune checkpoint blockade (ICB)
- (2019) Fangping Ren et al. OncoTargets and Therapy
- Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα
- (2019) Janet Sim et al. mAbs
- T Cell Dysfunction in Cancer Immunity and Immunotherapy
- (2019) Anliang Xia et al. Frontiers in Immunology
- Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors
- (2019) Assaf Zinger et al. ACS Nano
- Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem
- (2019) Jiayan Lang et al. ACS Nano
- Treg-mediated acquired resistance to immune checkpoint inhibitors
- (2019) Reem Saleh et al. CANCER LETTERS
- Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors
- (2019) Xueqiong Zhang et al. JOURNAL OF CONTROLLED RELEASE
- Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
- (2019) Tongyan Liu et al. Journal of Hematology & Oncology
- Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
- (2019) Anqi Lin et al. Molecular Cancer
- Neoantigen vaccine: an emerging tumor immunotherapy
- (2019) Miao Peng et al. Molecular Cancer
- The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
- (2019) Lea Monteran et al. Frontiers in Immunology
- MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers
- (2019) Livingstone Fultang et al. EBioMedicine
- Myeloid immunosuppression and immune checkpoints in the tumor microenvironment
- (2019) Kyohei Nakamura et al. Cellular & Molecular Immunology
- Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice
- (2019) Lisa Munakata et al. JOURNAL OF CONTROLLED RELEASE
- The role of exosomal PD-L1 in tumor progression and immunotherapy
- (2019) Feiting Xie et al. Molecular Cancer
- Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4
- (2019) Shuang Qin et al. Molecular Cancer
- New FH peptide-modified ultrasonic nanobubbles for delivery of doxorubicin to cancer-associated fibroblasts
- (2019) Lu Guo et al. Nanomedicine
- Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
- (2019) F. Zhang et al. Nature Communications
- Tumor Endothelial Heterogeneity in Cancer Progression
- (2019) Nako Maishi et al. Cancers
- CD64-targeted HO-1 RNA interference enhances chemosensitivity in orthotopic model of acute myeloid leukemia and patient-derived bone marrow cells
- (2019) Seok-Beom Yong et al. BIOMATERIALS
- TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages
- (2019) Zhipeng Liu et al. CANCER LETTERS
- Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGF β
- (2019) Markus Germann et al. EMBO Molecular Medicine
- CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
- (2019) Joseph A. Flores-Toro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Myeloid-Derived Suppressor Cells: Major Figures that Shape the Immunosuppressive and Angiogenic Network in Cancer
- (2019) Eleni-Kyriaki Vetsika et al. Cells
- Inhibiting extracellular vesicles formation and release: a review of EV inhibitors
- (2019) Mariadelva Catalano et al. Journal of Extracellular Vesicles
- Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma
- (2018) Qi Liu et al. ACS Nano
- Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours
- (2018) Qin Dai et al. ACS Nano
- Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth
- (2018) Yi Yang et al. CELL RESEARCH
- Targeting the CD73-adenosine axis in immuno-oncology
- (2018) David Allard et al. IMMUNOLOGY LETTERS
- Targeted delivery of pixantrone to neutrophils by poly(sialic acid)- p -octadecylamine conjugate modified liposomes with improved antitumor activity
- (2018) Xiang Luo et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Regulatory T cell-targeted hybrid nanoparticles combined with immuno-checkpoint blockage for cancer immunotherapy
- (2018) Wenquan Ou et al. JOURNAL OF CONTROLLED RELEASE
- Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts
- (2018) Diana Avery et al. MATRIX BIOLOGY
- Advances in targeted nanotherapeutics: From bioconjugation to biomimicry
- (2018) Danielle M. Valcourt et al. Nano Research
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa
- (2018) Kabir A. Khan et al. Nature Reviews Clinical Oncology
- Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
- (2018) Yan Lan et al. Science Translational Medicine
- Prognostic utility of baseline neutrophil-to-lymphocyte ratio in patients receiving immune checkpoint inhibitors: a review and meta-analysis
- (2018) Danielle Benedict Sacdalan et al. OncoTargets and Therapy
- Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
- (2018) Qirui Wang et al. Nature Communications
- Tissue-Dependent Tumor Microenvironments and Their Impact on Immunotherapy Responses
- (2018) Amanda J. Oliver et al. Frontiers in Immunology
- Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors
- (2018) Rebekka Weber et al. Frontiers in Immunology
- Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes
- (2018) Konrad Gabrusiewicz et al. OncoImmunology
- Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non–Small Cell Lung Carcinoma
- (2018) Chee Khoon Lee et al. JAMA Oncology
- Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
- (2018) Franz L. Ricklefs et al. Science Advances
- Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer
- (2018) Jun Zhao et al. ACS Nano
- M1 Macrophage-Derived Nanovesicles Potentiate the Anticancer Efficacy of Immune Checkpoint Inhibitors
- (2018) Yeon Woong Choo et al. ACS Nano
- Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers
- (2018) Limei Shen et al. ACS Nano
- 24-Month Overall Survival from KEYNOTE-021 Cohort G: Pemetrexed and Carboplatin with or without Pembrolizumab as First-Line Therapy for Advanced Nonsquamous Non–Small Cell Lung Cancer
- (2018) Hossein Borghaei et al. Journal of Thoracic Oncology
- Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
- (2018) Gang Chen et al. NATURE
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression
- (2018) Yan Lin et al. Frontiers in Immunology
- Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy
- (2018) Sara Musetti et al. ACS Nano
- Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade
- (2018) Hanna Grauers Wiktorin et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Extracellular matrix (ECM) stiffness and degradation as cancer drivers
- (2018) Masoud Najafi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The application of nanotechnology in immune checkpoint blockade for cancer treatment
- (2018) Huan Deng et al. JOURNAL OF CONTROLLED RELEASE
- Myeloid immune-checkpoint inhibition enters the clinical stage
- (2018) Timo K. van den Berg et al. Nature Reviews Clinical Oncology
- Targeting macrophages: therapeutic approaches in cancer
- (2018) Luca Cassetta et al. NATURE REVIEWS DRUG DISCOVERY
- Turning foes to friends: targeting cancer-associated fibroblasts
- (2018) Xueman Chen et al. NATURE REVIEWS DRUG DISCOVERY
- TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
- (2018) Ankur Chakravarthy et al. Nature Communications
- The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy
- (2018) Arabella Young et al. Cancer Immunology Research
- CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy
- (2018) Monika C. Brunner-Weinzierl et al. Frontiers in Immunology
- Cancer associated fibroblasts: is the force the path to the dark side?
- (2018) Jorge Barbazán et al. CURRENT OPINION IN CELL BIOLOGY
- Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
- (2017) Timothy M Nywening et al. GUT
- Modulation of cancer-specific immune responses by amino acid degrading enzymes
- (2017) Elina Timosenko et al. Immunotherapy
- Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1–Selected Advanced Non–Small-Cell Lung Cancer (BIRCH)
- (2017) Solange Peters et al. JOURNAL OF CLINICAL ONCOLOGY
- Nanotechnology based therapeutic modality to boost anti-tumor immunity and collapse tumor defense
- (2017) Xiaomeng Hu et al. JOURNAL OF CONTROLLED RELEASE
- The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production
- (2017) Colleen S. Netherby et al. JOURNAL OF IMMUNOLOGY
- Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts
- (2017) Fengming Yang et al. Molecular Cancer
- Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells
- (2017) Michael P. Plebanek et al. MOLECULAR CANCER THERAPEUTICS
- Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control
- (2017) Zipeng Zhen et al. NANO LETTERS
- Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
- (2017) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer
- (2017) Scott J. Antonia et al. NEW ENGLAND JOURNAL OF MEDICINE
- First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer
- (2017) David P. Carbone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma
- (2017) Joaquim Bellmunt et al. NEW ENGLAND JOURNAL OF MEDICINE
- PI3Kγ Activates Integrin α 4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression
- (2017) Philippe Foubert et al. Cancer Immunology Research
- Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment
- (2017) Janna Michaeli et al. OncoImmunology
- Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors
- (2016) Lei Miao et al. CANCER RESEARCH
- Regulatory T cells in cancer immunotherapy
- (2016) Atsushi Tanaka et al. CELL RESEARCH
- Targeting regulatory T cells in tumors
- (2016) Chang Liu et al. FEBS Journal
- Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas
- (2016) Francesca Mascia et al. INTERNATIONAL JOURNAL OF CANCER
- Exosomes and tumor-mediated immune suppression
- (2016) Theresa L. Whiteside JOURNAL OF CLINICAL INVESTIGATION
- Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system
- (2016) Binlong Chen et al. JOURNAL OF CONTROLLED RELEASE
- Sigma receptor-mediated targeted delivery of anti-angiogenic multifunctional nanodrugs for combination tumor therapy
- (2016) Yuanke Li et al. JOURNAL OF CONTROLLED RELEASE
- Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation
- (2016) Shi-Yong Li et al. JOURNAL OF CONTROLLED RELEASE
- Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes
- (2016) Joshua L. Hood MEDICAL HYPOTHESES
- A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts
- (2016) Binlong Chen et al. Nanomedicine-Nanotechnology Biology and Medicine
- Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
- (2016) Olivier De Henau et al. NATURE
- An essential role for the IL-2 receptor in Treg cell function
- (2016) Takatoshi Chinen et al. NATURE IMMUNOLOGY
- Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
- (2016) Jonas Kloepper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia
- (2016) Xiangrong Liu et al. STROKE
- Extracellular vesicles as new players in angiogenesis
- (2016) Sharad Kholia et al. VASCULAR PHARMACOLOGY
- PD-L1 expression in human cancers and its association with clinical outcomes
- (2016) Jinming Yu et al. OncoTargets and Therapy
- Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma
- (2016) Bo-Gen Ye et al. Oncotarget
- Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
- (2016) Hideyuki Takahashi et al. Oncotarget
- Analysis of nanoparticle delivery to tumours
- (2016) Stefan Wilhelm et al. Nature Reviews Materials
- Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors
- (2016) Rikke B. Holmgaard et al. EBioMedicine
- Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells
- (2015) João Conde et al. ADVANCED FUNCTIONAL MATERIALS
- Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery
- (2015) Tianjiao Ji et al. ADVANCED MATERIALS
- Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells
- (2015) Thomas Condamine et al. Annual Review of Medicine
- TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients
- (2015) D. M. S. Hossain et al. CLINICAL CANCER RESEARCH
- Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma
- (2015) A. Scholz et al. EMBO Molecular Medicine
- “Velcro” Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular Phagocytosis
- (2015) Chia Chi M. Ho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exosome mediated communication within the tumor microenvironment
- (2015) Lara Milane et al. JOURNAL OF CONTROLLED RELEASE
- Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche
- (2015) Pegah Ghiabi et al. Journal of Translational Medicine
- CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
- (2015) Xiaojuan Liu et al. NATURE MEDICINE
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
- (2015) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab versus Ipilimumab in Advanced Melanoma
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- A multi-targeted approach to suppress tumor-promoting inflammation
- (2015) Abbas K. Samadi et al. SEMINARS IN CANCER BIOLOGY
- Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin
- (2015) Chakrapani Tripathi et al. Oncotarget
- The Role of Mechanical Forces in Tumor Growth and Therapy
- (2014) Rakesh K. Jain et al. Annual Review of Biomedical Engineering
- Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells
- (2014) Moonkyu Lee et al. ARCHIVES OF PHARMACAL RESEARCH
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
- (2014) Y. Zhu et al. CANCER RESEARCH
- Tumor-Associated Macrophages: From Mechanisms to Therapy
- (2014) Roy Noy et al. IMMUNITY
- Current advances in T-cell-based cancer immunotherapy
- (2014) Mingjun Wang et al. Immunotherapy
- Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan
- (2014) Aditya G. Kohli et al. JOURNAL OF CONTROLLED RELEASE
- Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors
- (2014) Daniel W. Beury et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice
- (2014) Hong Qin et al. NATURE MEDICINE
- Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
- (2014) Gregory T Motz et al. NATURE MEDICINE
- From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
- (2014) Paola Italiani et al. Frontiers in Immunology
- Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
- (2014) Martin Augsten Frontiers in Oncology
- Immunotherapeutic strategies for relapse control in acute myeloid leukemia
- (2013) Anna Martner et al. BLOOD REVIEWS
- Hampering Immune Suppressors
- (2013) Sabrin Husein Albeituni et al. CANCER JOURNAL
- Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
- (2013) D. E. Sanford et al. CLINICAL CANCER RESEARCH
- STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients
- (2013) David Vasquez-Dunddel et al. JOURNAL OF CLINICAL INVESTIGATION
- Myeloid-Derived Suppressor Cells Regulate Growth of Multiple Myeloma by Inhibiting T Cells in Bone Marrow
- (2013) I. R. Ramachandran et al. JOURNAL OF IMMUNOLOGY
- At the Bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy
- (2013) Margaret K. Callahan et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival
- (2013) M. Cieslewicz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment
- (2012) Kosuke Akiyama et al. AMERICAN JOURNAL OF PATHOLOGY
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
- (2012) Valbona Luga et al. CELL
- Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment
- (2012) T. Lu et al. CLINICAL CANCER RESEARCH
- The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
- (2012) S. B. Willingham et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel strategy for modulation of MDSC to enhance cancer immunotherapy
- (2012) Tomar Ghansah OncoImmunology
- Mechanisms of Leukocyte Transendothelial Migration
- (2011) William A. Muller Annual Review of Pathology-Mechanisms of Disease
- Enzymatic and non-enzymatic activities of SHIP-1 in signal transduction and cancer
- (2011) Claude Condé et al. BIOCHEMICAL PHARMACOLOGY
- Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
- (2011) Michael C. Schmid et al. CANCER CELL
- Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
- (2011) Jacky G. Goetz et al. CELL
- The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation
- (2011) Holger Hackstein et al. CELLULAR IMMUNOLOGY
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Selection and characterization of tenascin C targeting peptide
- (2011) Mee Young Kim et al. MOLECULES AND CELLS
- Transtumoral targeting enabled by a novel neuropilin-binding peptide
- (2011) L Roth et al. ONCOGENE
- VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
- (2011) J. T. O'Connell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
- (2011) Douglas D. Taylor et al. Seminars in Immunopathology
- Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
- (2010) David G. DeNardo et al. CANCER AND METASTASIS REVIEWS
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
- (2010) Neta Erez et al. CANCER CELL
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- (2010) Bin-Zhi Qian et al. CELL
- CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
- (2010) Kyle J. Eash et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells
- (2010) S. Nagaraj et al. JOURNAL OF IMMUNOLOGY
- Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
- (2010) Subhra K Biswas et al. NATURE IMMUNOLOGY
- Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance
- (2010) L. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autocrine TGF- and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
- (2010) Y. Kojima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemokines and chemokine receptors: new insights into cancer-related inflammation
- (2010) Gwendal Lazennec et al. TRENDS IN MOLECULAR MEDICINE
- High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors
- (2009) Laureen S. Ojalvo et al. AMERICAN JOURNAL OF PATHOLOGY
- DNA Damage Drives an Activin A-Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
- (2009) C. Fordyce et al. Cancer Prevention Research
- Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma
- (2009) Fei Zhao et al. IMMUNOLOGY
- Maturation of high-density lipoproteins
- (2009) A. Y. Shih et al. Journal of the Royal Society Interface
- Proteomic and immunologic analyses of brain tumor exosomes
- (2008) Michael W. Graner et al. FASEB JOURNAL
- Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice
- (2008) Maciej Kujawski et al. JOURNAL OF CLINICAL INVESTIGATION
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started