Tumor Endothelial Heterogeneity in Cancer Progression

The functional role of integrins during intra- and extravasation within the metastatic cascade

(2019) Greta Sökeland et al.   Molecular Cancer

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

(2019) Stefanie Hendrikx et al.   Cell Reports

Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1

(2019) Yuichi Akatsu et al.   Molecular Oncology

Single-Cell Transcriptome Analyses Reveal Endothelial Cell Heterogeneity in Tumors and Changes following Antiangiogenic Treatment

(2018) Qi Zhao et al.   CANCER RESEARCH

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

(2018) Qirui Wang et al.   Nature Communications

Immunomodulation of Tumor Vessels: It Takes Two to Tango

(2018) Anna Johansson-Percival et al.   TRENDS IN IMMUNOLOGY

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells

(2017) Takayuki Hojo et al.   Oncotarget

The hypoxic microenvironment: A determinant of cancer stem cell evolution

(2016) Amancio Carnero et al.   BIOESSAYS

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance

(2016) H. Naito et al.   CANCER RESEARCH

Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes

(2016) Joshua L. Hood   MEDICAL HYPOTHESES

Tumor endothelial cells express high pentraxin 3 levels

(2016) Kyoko Hida et al.   PATHOLOGY INTERNATIONAL

Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma

(2016) Bo-Gen Ye et al.   Oncotarget

Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan

(2016) Nako Maishi et al.   Scientific Reports

Inhibition of Multidrug Transporter in Tumor Endothelial Cells Enhances Antiangiogenic Effects of Low-Dose Metronomic Paclitaxel

(2015) Kosuke Akiyama et al.   AMERICAN JOURNAL OF PATHOLOGY

Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

(2015) Yoku Hayakawa et al.   CANCER CELL

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer

(2015) S. I. Cunha et al.   CANCER RESEARCH

Tumor Endothelial Cells with Distinct Patterns of TGF -Driven Endothelial-to-Mesenchymal Transition

(2015) L. Xiao et al.   CANCER RESEARCH

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

(2015) A. Scholz et al.   EMBO Molecular Medicine

CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property

(2015) Kenji Yamada et al.   INTERNATIONAL JOURNAL OF CANCER

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

(2015) Pegah Ghiabi et al.   Journal of Translational Medicine

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

(2015) Anna Johansson-Percival et al.   Cell Reports

Endothelial Progenitor Cells in Tumor Angiogenesis: Another Brick in the Wall

(2015) Marina Marçola et al.   Stem Cells International

Neoplastic cells are a rare component in human glioblastoma microvasculature

(2015) Fausto J. Rodriguez et al.   Oncotarget

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

Crosstalk between Glioma-Initiating Cells and Endothelial Cells Drives Tumor Progression

(2014) H.-M. Jeon et al.   CANCER RESEARCH

Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells

(2014) Tsuguteru Otsubo et al.   CANCER SCIENCE

Suprabasin as a novel tumor endothelial cell marker

(2014) Mohammad T. Alam et al.   CANCER SCIENCE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype

(2014) Hitomi Ohmura-Kakutani et al.   PLoS One

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis

(2013) T Osawa et al.   BRITISH JOURNAL OF CANCER

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Anti-CD73 therapy impairs tumor angiogenesis

(2013) Bertrand Allard et al.   INTERNATIONAL JOURNAL OF CANCER

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

(2013) Miyako Kondoh et al.   PLoS One

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment

(2012) Kosuke Akiyama et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterogeneity of Tumor Endothelial Cells

(2012) Noritaka Ohga et al.   AMERICAN JOURNAL OF PATHOLOGY

Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells

(2012) K Yamamoto et al.   BRITISH JOURNAL OF CANCER

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

CXCR7: A novel tumor endothelial marker in renal cell carcinoma

(2012) Nako Maishi et al.   PATHOLOGY INTERNATIONAL

Tumor-Derived Microvesicles Induce Proangiogenic Phenotype in Endothelial Cells via Endocytosis

(2012) Taisuke Kawamoto et al.   PLoS One

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-targeted TNF  stabilizes tumor vessels and enhances active immunotherapy

(2012) A. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT: A new vision of hypoxia promoting cancer progression

(2011) Jian Jiang et al.   CANCER BIOLOGY & THERAPY

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice

(2011) Long Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolated tumor endothelial cells maintain specific character during long-term culture

(2010) Kohei Matsuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels

(2010) S. M. Taylor et al.   BLOOD

Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium

(2010) D. M. Brantley-Sieders et al.   CANCER RESEARCH

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Dynamics of endothelial cell behavior in sprouting angiogenesis

(2010) Hanna M Eilken et al.   CURRENT OPINION IN CELL BIOLOGY

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

(2009) Tomoshige Akino et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Human Hepatocellular Carcinoma Tumor-derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells

(2009) Y.-Q. Xiong et al.   CLINICAL CANCER RESEARCH

Growth factors in tumor microenvironment

(2009) Xuejing Zhang   Frontiers in Bioscience-Landmark

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands

(2009) B. A. Zabel et al.   JOURNAL OF IMMUNOLOGY

Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis

(2008) H. Chen et al.   BLOOD

Endothelial cell-derived bone mo rphogenetic proteins control proliferation of neural stem/progenitor cells

(2008) Céline Mathieu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE