Nusinersen Modulates Proteomics Profiles of Cerebrospinal Fluid in Spinal Muscular Atrophy Type 1 Patients
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Title
Nusinersen Modulates Proteomics Profiles of Cerebrospinal Fluid in Spinal Muscular Atrophy Type 1 Patients
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages 4329
Publisher
MDPI AG
Online
2021-04-22
DOI
10.3390/ijms22094329
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Note: Only part of the references are listed.- Intracellular and Extracellular Markers of Lethality in Osteogenesis Imperfecta: A Quantitative Proteomic Approach
- (2021) Luca Bini et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Lipids and Alzheimer’s Disease
- (2020) Yu-Chia Kao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content
- (2020) Kalia Kyriakou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nusinersen treatment and cerebrospinal fluid neurofilaments: An explorative study on Spinal Muscular Atrophy type 3 patients
- (2020) Irene Faravelli et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Cerebrospinal fluid proteomic profiling in nusinersen‐treated patients with spinal muscular atrophy
- (2020) Tobias Kessler et al. JOURNAL OF NEUROCHEMISTRY
- APOE in the normal brain
- (2020) Sarah A. Flowers et al. NEUROBIOLOGY OF DISEASE
- Oxidized protein aggregates: Formation and biological effects
- (2020) Tilman Grune FREE RADICAL BIOLOGY AND MEDICINE
- Glial cells involvement in spinal muscular atrophy: Could SMA be a neuroinflammatory disease?
- (2020) Elena Abati et al. NEUROBIOLOGY OF DISEASE
- Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model
- (2020) María T. Berciano et al. Scientific Reports
- Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
- (2020) Hannah Chew et al. Frontiers in Physiology
- New Treatments in Spinal Muscular Atrophy: Positive Results and New Challenges
- (2020) Sonia Messina et al. Journal of Clinical Medicine
- Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy
- (2020) Shiori Ando et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Haptoglobin Improves Acute Phase Response and Endotoxin Tolerance in Response to Bacterial LPS
- (2019) Swathi M Raju et al. IMMUNOLOGY LETTERS
- Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
- (2019) Anvesh K. R. Dasari et al. Scientific Reports
- NFL is a marker of treatment response in children with SMA treated with nusinersen
- (2019) Bob Olsson et al. JOURNAL OF NEUROLOGY
- Apolipoprotein A-I Crosses the Blood-Brain Barrier through Clathrin-Independent and Cholesterol-Mediated Endocytosis
- (2019) Andrew L. Zhou et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro
- (2019) Roberta Dal Magro et al. Frontiers in Neuroscience
- Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson’s Disease
- (2019) Irina Alecu et al. Frontiers in Neuroscience
- Neurofilament as a potential biomarker for spinal muscular atrophy
- (2019) Basil T. Darras et al. Annals of Clinical and Translational Neurology
- APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm
- (2019) Diego Martínez-López et al. EBioMedicine
- Nusinersen in type 1 spinal muscular atrophy: Twelve‐month real‐world data
- (2019) Marika Pane et al. ANNALS OF NEUROLOGY
- Abnormal fatty acid metabolism is a core component of spinal muscular atrophy
- (2019) Marc‐Olivier Deguise et al. Annals of Clinical and Translational Neurology
- Neurofilament Heavy Chain and Tau Protein Are Not Elevated in Cerebrospinal Fluid of Adult Patients with Spinal Muscular Atrophy during Loading with Nusinersen
- (2019) Andreas Totzeck et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients
- (2019) Claudia Landi et al. JOURNAL OF NEUROVIROLOGY
- Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis
- (2019) Roberta Magliozzi et al. Annals of Clinical and Translational Neurology
- Sitting in patients with spinal muscular atrophy type 1 treated with nusinersen
- (2019) Karolina Aragon‐Gawinska et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- Long noncoding RNAs APOA1-AS, IFNG-AS1, RMRP and their related biomolecules in Egyptian patients with relapsing-remitting multiple sclerosis: Relation to disease activity and patient disability
- (2019) Heba R. Ghaiad et al. Journal of Advanced Research
- Brain-derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons
- (2018) Maria S. Spagnuolo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons
- (2018) João R. Gomes et al. JOURNAL OF NEUROCHEMISTRY
- Aging and Apolipoprotein E in HIV Infection
- (2018) Rebeca Geffin et al. JOURNAL OF NEUROVIROLOGY
- Correlation between SMA type and SMN2 copy number revisited: An analysis of 625 unrelated Spanish patients and a compilation of 2834 reported cases
- (2018) Maite Calucho et al. NEUROMUSCULAR DISORDERS
- A severe mouse model of spinal muscular atrophy develops early systemic inflammation
- (2018) Bo Wan et al. HUMAN MOLECULAR GENETICS
- Human Serum Transthyretin Levels Correlate Inversely with Alzheimer's Disease
- (2018) Sun-Ho Han et al. JOURNAL OF ALZHEIMERS DISEASE
- An observational study of functional abilities in infants, children, and adults with type 1 SMA
- (2018) Marika Pane et al. NEUROLOGY
- Apolipoprotein E Affects In Vitro Axonal Growth and Regeneration via the MAPK Signaling Pathway
- (2018) Cheng Yin et al. CELL TRANSPLANTATION
- Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
- (2018) Marina Iridoy et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Linking amyotrophic lateral sclerosis and spinal muscular atrophy through RNA-transcriptome homeostasis: a genomics perspective
- (2017) Margarida Gama-Carvalho et al. JOURNAL OF NEUROCHEMISTRY
- Neuroprotective potential of high-dose biotin
- (2017) Mark F. McCarty et al. MEDICAL HYPOTHESES
- Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy
- (2017) Richard S. Finkel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prevalence, incidence and carrier frequency of 5q–linked spinal muscular atrophy – a literature review
- (2017) Ingrid E. C. Verhaart et al. Orphanet Journal of Rare Diseases
- CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage
- (2017) Ran Liu et al. STROKE
- Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels
- (2017) Jerome Robert et al. eLife
- Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy
- (2016) Eilidh Somers et al. ANNALS OF NEUROLOGY
- Central Nervous System LipoproteinsHighlights
- (2016) Robert W. Mahley ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Spinal Muscular Atrophy: More than a Disease of Motor Neurons?
- (2016) L. A. Nash et al. CURRENT MOLECULAR MEDICINE
- Motor neuron mitochondrial dysfunction in spinal muscular atrophy
- (2016) Nimrod Miller et al. HUMAN MOLECULAR GENETICS
- The Complex Role of Apolipoprotein E in Alzheimer’s Disease: an Overview and Update
- (2016) Laura Mahoney-Sanchez et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study
- (2016) Richard S Finkel et al. LANCET
- Increased expression of ApoA1 after neuronal injury may be beneficial for healing
- (2016) Mohor B. Sengupta et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Commonality amid diversity: Multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy
- (2016) Heidi R. Fuller et al. NEUROMUSCULAR DISORDERS
- Astrocytes influence the severity of spinal muscular atrophy
- (2015) Hansjörg Rindt et al. HUMAN MOLECULAR GENETICS
- Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway
- (2015) Caroline S. Casey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 209th ENMC International Workshop: Outcome Measures and Clinical Trial Readiness in Spinal Muscular Atrophy 7–9 November 2014, Heemskerk, The Netherlands
- (2015) Richard Finkel et al. NEUROMUSCULAR DISORDERS
- Importance of Apolipoprotein A-I in Multiple Sclerosis
- (2015) Lidia A. Gardner et al. Frontiers in Pharmacology
- ROS Function in Redox Signaling and Oxidative Stress
- (2014) Michael Schieber et al. CURRENT BIOLOGY
- Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy
- (2014) Thomas M. Wishart et al. JOURNAL OF CLINICAL INVESTIGATION
- More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration
- (2014) Courtney Lane-Donovan et al. NEURON
- The GOA database: Gene Ontology annotation updates for 2015
- (2014) Rachael P. Huntley et al. NUCLEIC ACIDS RESEARCH
- CSF Proteomics of Secondary Phase Spinal Cord Injury in Human Subjects: Perturbed Molecular Pathways Post Injury
- (2014) Mohor Biplab Sengupta et al. PLoS One
- ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets
- (2014) Emmanuelle Coque et al. Frontiers in Neuroscience
- Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease?
- (2013) Monir Shababi et al. JOURNAL OF ANATOMY
- Clinical and neuropathological features of X-linked spinal muscular atrophy (SMAX2) associated with a novel mutation in the UBA1 gene
- (2013) Nomazulu Dlamini et al. NEUROMUSCULAR DISORDERS
- Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy
- (2013) Chantal A Mutsaers et al. Genome Medicine
- Transthyretin is a metallopeptidase with an inducible active site
- (2012) Márcia A. Liz et al. BIOCHEMICAL JOURNAL
- Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis
- (2012) Kuo-Hsuan Chang et al. CLINICA CHIMICA ACTA
- Apolipoprotein E Enhances Endothelial-NO Production by Modulating Caveolin 1 Interaction With Endothelial NO Synthase
- (2012) Lili Yue et al. HYPERTENSION
- Quantitative proteomic analysis of serum proteins in patients with Parkinson’s disease using an isobaric tag for relative and absolute quantification labeling, two-dimensional liquid chromatography, and tandem mass spectrometry
- (2011) Xiaping Zhang et al. ANALYST
- Spinal Muscular Atrophy
- (2011) Stephen J. Kolb ARCHIVES OF NEUROLOGY
- Proteomic assessment of a cell model of spinal muscular atrophy
- (2011) Chia-Yen Wu et al. BMC NEUROSCIENCE
- The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin
- (2011) Anna Nölle et al. HUMAN MOLECULAR GENETICS
- Increased Prothrombin, Apolipoprotein A-IV, and Haptoglobin in the Cerebrospinal Fluid of Patients with Huntington's Disease
- (2011) Yen-Chu Huang et al. PLoS One
- REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
- (2011) Fran Supek et al. PLoS One
- Apolipoproteins in the brain: implications for neurological and psychiatric disorders
- (2010) David A Elliott et al. Clinical Lipidology
- Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model
- (2010) Mélissa Bowerman et al. HUMAN MOLECULAR GENETICS
- Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease
- (2010) Terry L. Lewis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reelin Signals through Apolipoprotein E Receptor 2 and Cdc42 to Increase Growth Cone Motility and Filopodia Formation
- (2010) J. Leemhuis et al. JOURNAL OF NEUROSCIENCE
- Use of haptoglobin and transthyretin as potential biomarkers for the preclinical diagnosis of Parkinson's disease
- (2010) S. Argüelles et al. NEUROCHEMISTRY INTERNATIONAL
- The Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND): Test development and reliability
- (2010) A.M. Glanzman et al. NEUROMUSCULAR DISORDERS
- QuickGO: a web-based tool for Gene Ontology searching
- (2009) D. Binns et al. BIOINFORMATICS
- Haptoglobin binds apolipoprotein E and influences cholesterol esterification in the cerebrospinal Fluid
- (2009) Alfonso Salvatore et al. JOURNAL OF NEUROCHEMISTRY
- Transthyretin Internalization by Sensory Neurons Is Megalin Mediated and Necessary for Its Neuritogenic Activity
- (2009) C. E. Fleming et al. JOURNAL OF NEUROSCIENCE
- Inflammation in ALS and SMA: Sorting out the good from the evil
- (2009) Dimitra Papadimitriou et al. NEUROBIOLOGY OF DISEASE
- Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)
- (2009) Johannes Brettschneider et al. NEUROSCIENCE LETTERS
- Rare Missense and Synonymous Variants in UBE1 Are Associated with X-Linked Infantile Spinal Muscular Atrophy
- (2008) Juliane Ramser et al. AMERICAN JOURNAL OF HUMAN GENETICS
- SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing
- (2008) Zhenxi Zhang et al. CELL
- Comparative Proteomics Analysis of Cerebrospinal Fluid of Patients with Guillain–Barré Syndrome
- (2008) Yin-Rong Yang et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
- (2008) Shingo Kariya et al. HUMAN MOLECULAR GENETICS
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