Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

(2018) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination

(2018) Nathanael J Lee et al.   BRAIN

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

(2018) Jae Kyu Ryu et al.   NATURE IMMUNOLOGY

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro

(2017) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study

(2017) Gabriele Farina et al.   Journal of Neuroinflammation

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

(2017) Mark A. Petersen et al.   NEURON

A multi-biomarker follow-up study of patients with multiple sclerosis

(2016) Morten Stilund et al.   Brain and Behavior

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants

(2015) Kevin Blauth et al.   ACTA NEUROPATHOLOGICA

In vitro study of the direct effect of extracellular hemoglobin on myelin components

(2015) Vladimir V. Bamm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exploring the origins of grey matter damage in multiple sclerosis

(2015) Massimiliano Calabrese et al.   NATURE REVIEWS NEUROSCIENCE

Meningeal inflammation in multiple sclerosis

(2015) Caterina Mainero et al.   NEUROLOGY

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation

(2015) Laure Michel et al.   Frontiers in Immunology

Biomarkers of Inflammation and Axonal Degeneration/Damage in Patients with Newly Diagnosed Multiple Sclerosis: Contributions of the Soluble CD163 CSF/Serum Ratio to a Biomarker Panel

(2015) Morten Stilund et al.   PLoS One

Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics

(2014) Oscar G. Vidaurre et al.   BRAIN

Blood–brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation

(2014) Rui Ding et al.   BRAIN RESEARCH

“Back to the future” or iron in the MS brain – Commentary on “Perivascular iron deposits are associated with protein nitration in cerebral experimental autoimmune encephalomyelitis

(2014) Vladimir V. Bamm et al.   NEUROSCIENCE LETTERS

Monocyte Expression and Soluble Levels of the Haemoglobin Receptor (CD163/sCD163) and the Mannose Receptor (MR/sMR) in Septic and Critically Ill Non-Septic ICU Patients

(2014) Anders G. Kjærgaard et al.   PLoS One

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

Early detection of thrombin activity in neuroinflammatory disease

(2013) Dimitrios Davalos et al.   ANNALS OF NEUROLOGY

Structural Basis for Inflammation-driven Shedding of CD163 Ectodomain and Tumor Necrosis Factor-α in Macrophages

(2013) Anders Etzerodt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Denaturation of Serum Proteome Reveals a Significant Amount of Hidden Information in Complex Mixtures of Proteins

(2013) Vincenzo Verdoliva et al.   PLoS One

Coagulation in Inflammatory Diseases of the Central Nervous System

(2013) Joab Chapman   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Activation of B cells by non-canonical helper signals

(2012) Andrea Cerutti et al.   EMBO REPORTS

Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro

(2012) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

Blood-Brain Barrier Disruption and Oxidative Stress in Guinea Pig after Systemic Exposure to Modified Cell-Free Hemoglobin

(2011) Omer I. Butt et al.   AMERICAN JOURNAL OF PATHOLOGY

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains

(2011) Zhiren Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging

(2009) M. J. Nielsen et al.   BLOOD

Grey matter pathology in clinically early multiple sclerosis: Evidence from magnetic resonance imaging

(2009) Declan Chard et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking

(2009) C. E. Teunissen et al.   NEUROLOGY