Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature

Omega-3 fatty-acids modulate symptoms of depressive disorder, serum levels of omega-3 fatty acids and omega-6/omega-3 ratio in children. A randomized, double-blind and controlled trial

(2020) Assoc. prof. Trebatická Jana et al.   PSYCHIATRY RESEARCH

Effects of Fish Oil Monotherapy on Depression and Prefrontal Neurochemistry in Adolescents at High Risk for Bipolar I Disorder: A 12-Week Placebo-Controlled Proton Magnetic Resonance Spectroscopy Trial

(2020) Robert K. McNamara et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

The Association Between Vascular Inflammation and Depressive Disorder. Causality, Biomarkers and Targeted Treatment

(2020) Hans O. Kalkman   Pharmaceuticals

Effect of one year krill oil supplementation on depressive symptoms and self-esteem of Dutch adolescents: A randomized controlled trial

(2020) I.S.M. van der Wurff et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women

(2019) Daisuke Nishi et al.   BRAIN BEHAVIOR AND IMMUNITY

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

(2018) Wolf-Hagen Schunck et al.   PHARMACOLOGY & THERAPEUTICS

Eicosapentaenoic and docosahexaenoic acids have different effects on peripheral phospholipase A2 gene expressions in acute depressed patients

(2018) Kuan-Pin Su et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring

(2018) Charlotte Rey et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress

(2018) Marilena Lepretti et al.   Nutrients

Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial

(2018) Ondine van de Rest et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain

(2018) C. Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

New approaches and challenges to targeting the endocannabinoid system

(2018) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders - Results from a double-blind, randomized and placebo-controlled clinical trial

(2018) Leila Jahangard et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans

(2018) Wole Akosile et al.   PSYCHIATRY RESEARCH

Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial

(2018) J. Tayama et al.   JOURNAL OF AFFECTIVE DISORDERS

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro

(2017) Biqiong Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway

(2017) Satoshi Deyama et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Lipid composition of membrane microdomains isolated detergent-free from PUFA supplemented RAW264.7 macrophages

(2017) Christine Hellwing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy

(2017) Paula Kopschina Feltes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Maresin 1 induces a novel pro-resolving phenotype in human platelets

(2017) K. L. Lannan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Polyunsaturated fatty acids and endocannabinoids in health and disease

(2017) Hércules Rezende Freitas et al.   NUTRITIONAL NEUROSCIENCE

Anti-inflammatory ω-3 endocannabinoid epoxides

(2017) Daniel R. McDougle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

(2017) Satoshi Deyama et al.   PSYCHOPHARMACOLOGY

Toll-Like Receptor 4 in Paraventricular Nucleus Mediates Visceral Hypersensitivity Induced by Maternal Separation

(2017) Hui-Li Tang et al.   Frontiers in Pharmacology

Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study

(2017) Jana Trebatická et al.   Child and Adolescent Psychiatry and Mental Health

Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target

(2017) Osama Elshenawy et al.   Pharmaceutics

Effects of Omega-3 in the treatment of violent schizophrenia patients

(2017) Yi Qiao et al.   SCHIZOPHRENIA RESEARCH

ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance

(2017) Corneliu Sima et al.   Scientific Reports

Angiotensin-(1–7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation

(2016) Shuang-Ming Cai et al.   ANTIOXIDANTS & REDOX SIGNALING

Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin

(2016) Kanita Salic et al.   ATHEROSCLEROSIS

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32

(2016) Mattia Schmid et al.   JOURNAL OF IMMUNOLOGY

Effect of n-3 fatty acids on the expression of inflammatory genes in THP-1 macrophages

(2016) Bénédicte Allam-Ndoul et al.   Lipids in Health and Disease

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

The role of 20-HETE in cardiovascular diseases and its risk factors

(2016) Maayan Waldman et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function

(2016) Ji-Won Lee et al.   Nature Communications

Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder

(2016) R J T Mocking et al.   Translational Psychiatry

LPS- orPseudomonas aeruginosa-mediated activation of the macrophage TLR4 signaling cascade depends on membrane lipid composition

(2016) Axel Schoeniger et al.   PeerJ

Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea

(2015) Yongsoon Park et al.   ANNALS OF NUTRITION AND METABOLISM

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

(2015) H. Hasturk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Brain membrane lipids in major depression and anxiety disorders

(2015) Christian P. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism

(2015) Arthur A. Spector et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inflammatory cytokine-associated depression

(2015) Francis E. Lotrich   BRAIN RESEARCH

Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease

(2015) Joanne J. Liu et al.   BRAIN RESEARCH

Endocannabinoid signalling in innate and adaptive immunity

(2015) Valerio Chiurchiù et al.   IMMUNOLOGY

Fish consumption and risk of depression: a meta-analysis

(2015) Fang Li et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages

(2015) Magdalena Herová et al.   JOURNAL OF IMMUNOLOGY

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

(2015) M H Rapaport et al.   MOLECULAR PSYCHIATRY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients “at risk” for major depression

(2015) Shantel L. Duffy et al.   NUTRITION

Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alter depression status and decrease symptomology among young adults with depression: A preliminary randomized and placebo controlled trial

(2015) Annie T. Ginty et al.   PSYCHIATRY RESEARCH

Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?

(2015) Emily Boorman et al.   PSYCHOPHARMACOLOGY

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives

(2015) Chiara Cipollina   Biomed Research International

Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders

(2015) Kuan-Pin Su et al.   Clinical Psychopharmacology and Neuroscience

Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

(2014) Kuan-Pin Su et al.   BIOLOGICAL PSYCHIATRY

The Endocannabinoid/Endovanilloid System and Depression

(2014) Irena Smaga et al.   Current Neuropharmacology

The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial

(2014) Afshin Gharekhani et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

A review of the relationship between proinflammatory cytokines and major depressive disorder

(2014) Juan Joseph Young et al.   JOURNAL OF AFFECTIVE DISORDERS

A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression

(2014) David Mischoulon et al.   JOURNAL OF CLINICAL PSYCHIATRY

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway

(2014) Robert Fischer et al.   JOURNAL OF LIPID RESEARCH

Omega-3 Polyunsaturated Fatty Acids Protect Neural Progenitor Cells against Oxidative Injury

(2014) Qiang Liu et al.   Marine Drugs

Resolvin D1, a Metabolite of Omega-3 Polyunsaturated Fatty Acid, Decreases Post-Myocardial Infarct Depression

(2014) Kim Gilbert et al.   Marine Drugs

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Cytochrome P450–dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids

(2014) Cosima Arnold et al.   Pharmacological Reports

Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials

(2014) Giuseppe Grosso et al.   PLoS One

Inflamed moods: A review of the interactions between inflammation and mood disorders

(2014) Joshua D. Rosenblat et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men

(2014) Jan Philipp Schuchardt et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

(2013) Undine E. Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome: “A pilot trial”

(2013) Nahid Sohrabi et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Anti-inflammatory Effects of ω-3 Polyunsaturated Fatty Acids and Soluble Epoxide Hydrolase Inhibitors in Angiotensin-II–Dependent Hypertension

(2013) Arzu Ulu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

(2013) Chuck T. Chen et al.   JOURNAL OF LIPID RESEARCH

Increased 20-HETE Synthesis Explains Reduced Cerebral Blood Flow But Not Impaired Neurovascular Coupling after Cortical Spreading Depression in Rat Cerebral Cortex

(2013) J. C. Fordsmann et al.   JOURNAL OF NEUROSCIENCE

EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials

(2013) Julian G Martins   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Effect of Omega-3 Fatty Acids Supplementation on Depressive Symptoms and on Health-Related Quality of Life in the Treatment of Elderly Women with Depression: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

(2013) Mariangela Rondanelli et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Resolvin D1 and its GPCRs in resolution circuits of inflammation

(2013) Antonio Recchiuti   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Supplementation with B vitamins or n−3 fatty acids and depressive symptoms in cardiovascular disease survivors: ancillary findings from the SUpplementation with FOLate, vitamins B-6 and B-12 and/or OMega-3 fatty acids (SU.FOL.OM3) randomized trial

(2012) Valentina A Andreeva et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial

(2012) Janice K. Kiecolt-Glaser et al.   BRAIN BEHAVIOR AND IMMUNITY

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: A randomized, double-blind, placebo-controlled trial

(2012) Hassan Mozaffari-Khosravi et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omega-3 Fatty Acid Treatment, With or Without Cytidine, Fails to Show Therapeutic Properties in Bipolar Disorder

(2012) Beth L. Murphy et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?

(2012) Dariush Mozaffarian et al.   JOURNAL OF NUTRITION

Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids

(2012) Fraser Russell et al.   Marine Drugs

Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation and severity of depression

(2012) P-Y Lin et al.   MOLECULAR PSYCHIATRY

Comparison between the AA/EPA ratio in depressed and non depressed elderly females: omega-3 fatty acid supplementation correlates with improved symptoms but does not change immunological parameters

(2012) Angela Maria Rizzo et al.   Nutrition Journal

Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids

(2012) Martin Rossmeisl et al.   PLoS One

Red blood cell fatty acids are associated with depression in a case-control study of adolescents

(2012) J.V. Pottala et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Effects of n−3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction

(2011) Erik J Giltay et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial

(2011) Janice K. Kiecolt-Glaser et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial

(2011) Natalie Sinn et al.   BRITISH JOURNAL OF NUTRITION

n−3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization

(2011) David N. McMurray et al.   CHEMISTRY AND PHYSICS OF LIPIDS

The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study

(2011) Yaser Tajalizadekhoob et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression

(2011) M. Elizabeth Sublette et al.   JOURNAL OF CLINICAL PSYCHIATRY

Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder

(2011) Lev Gertsik et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Long chain omega 3 polyunsaturated fatty acids supplementation in the treatment of elderly depression: Effects on depressive symptoms, on phospholipids fatty acids profile and on health-related quality of life

(2011) Mariangela Rondanelli et al.   Journal of Nutrition Health & Aging

Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals

(2011) Niki Antypa et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis

(2011) M H Bloch et al.   MOLECULAR PSYCHIATRY

Supplementation with Eicosapentaenoic Omega-3 Fatty Acid Does Not Influence Serum Brain-Derived Neurotrophic Factor in Diabetes Mellitus Patients with Major Depression: A Randomized Controlled Pilot Study

(2011) Mariska Bot et al.   NEUROPSYCHOBIOLOGY

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development

(2011) Hee-Yong Kim et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Fish consumption and severely depressed mood, findings from the first national nutrition follow-up study

(2011) Yanfeng Li et al.   PSYCHIATRY RESEARCH

Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition

(2010) Laura F DeFina et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties

(2010) Michiel G.J. Balvers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids

(2010) Anne Konkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression

(2010) Pao-Yen Lin et al.   BIOLOGICAL PSYCHIATRY

Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: A randomized, double-blind placebo-controlled study

(2010) M. Bot et al.   JOURNAL OF AFFECTIVE DISORDERS

Complementary and Alternative Medicine in Major Depressive Disorder

(2010) Marlene P. Freeman et al.   JOURNAL OF CLINICAL PSYCHIATRY

The Efficacy of Omega-3 Supplementation for Major Depression

(2010) François Lespérance et al.   JOURNAL OF CLINICAL PSYCHIATRY

Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice

(2010) Mireille Basselin et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid–induced up-regulation of mitofusin 2

(2010) Yong Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fish and n-3 Polyunsaturated Fatty Acid Intake and Depressive Symptoms: Ryukyus Child Health Study

(2010) K. Murakami et al.   PEDIATRICS

Fish Consumption and Omega-3 Polyunsaturated Fatty Acids in Relation to Depressive Episodes: A Cross-Sectional Analysis

(2010) Anna Liisa Suominen-Taipale et al.   PLoS One

Docosapentaenoic acid (22:5n-3): A review of its biological effects

(2010) Gunveen Kaur et al.   PROGRESS IN LIPID RESEARCH

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Anandamide enhances IL-10 production in activated microglia by targeting CB2receptors: Roles of ERK1/2, JNK, and NF-κB

(2009) Fernando Correa et al.   GLIA

Omega-3 Augmentation of Sertraline in Treatment of Depression in Patients With Coronary Heart Disease

(2009) Robert M. Carney et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Double-Blind, Randomized Controlled Trial of Ethyl-Eicosapentaenoate for Major Depressive Disorder

(2009) David Mischoulon et al.   JOURNAL OF CLINICAL PSYCHIATRY

Increased Phospholipase A2 Activity and Inflammatory Response But Decreased Nerve Growth Factor Expression in the Olfactory Bulbectomized Rat Model of Depression: Effects of Chronic Ethyl-Eicosapentaenoate Treatment

(2009) C. Song et al.   JOURNAL OF NEUROSCIENCE

A Cytochrome P450-Derived Epoxygenated Metabolite of Anandamide Is a Potent Cannabinoid Receptor 2-Selective Agonist

(2009) N. T. Snider et al.   MOLECULAR PHARMACOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Comparative effects of DHA and EPA on cell function

(2009) Renata Gorjão et al.   PHARMACOLOGY & THERAPEUTICS

Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial

(2008) Michel Lucas et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Comparison of Therapeutic Effects of Omega-3 Fatty Acid Eicosapentaenoic Acid and Fluoxetine, Separately and in Combination, in Major Depressive Disorder

(2008) Shima Jazayeri et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Omega-3 Fatty Acids as a Treatment for Perinatal Depression: Randomized Double-Blind Placebo-Controlled Trial

(2008) Anne-Marie Rees et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

(2008) Andreas Artmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Omega-3 fatty acids and supportive psychotherapy for perinatal depression: A randomized placebo-controlled study

(2008) Marlene P. Freeman et al.   JOURNAL OF AFFECTIVE DISORDERS

Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

(2008) Ticyana Moralez da Silva et al.   JOURNAL OF AFFECTIVE DISORDERS

Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers

(2008) N Antypa et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Ethyl-Eicosapentaenoic Acid in First-Episode Psychosis. A 1H-MRS Study

(2008) Gregor E Berger et al.   NEUROPSYCHOPHARMACOLOGY

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

(2008) Chih-Chiang Chiu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women

(2008) Pierre Astorg et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms

(2007) Yvonne Freund-Levi et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY