Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy

Kynurenine pathway metabolites and suicidality

(2017) Elena Y. Bryleva et al.   NEUROPHARMACOLOGY

The embodied mind: A review on functional genomic and neurological correlates of mind-body therapies

(2017) David Muehsam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

(2016) Jerome Sarris et al.   AMERICAN JOURNAL OF PSYCHIATRY

Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis

(2016) Joshua D Rosenblat et al.   BIPOLAR DISORDERS

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Mapping inflammation onto mood: Inflammatory mediators of anhedonia

(2016) Walter Swardfager et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model

(2016) Anastasiya Slyepchenko et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

(2016) Anastasiya Slyepchenko et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Inflammation and Specific Symptoms of Depression

(2016) Markus Jokela et al.   JAMA Psychiatry

The Anti-Inflammatory Effects of Prostaglandins

(2016) Jose U. Scher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Use of Selective Serotonin Reuptake Inhibitors and Risks of Stroke in Patients with Obsessive Compulsive Disorder: A Population-Based Study

(2016) Che-Sheng Chu et al.   PLoS One

The importance of cytokines and autoantibodies in depression

(2015) Mariana Postal et al.   AUTOIMMUNITY REVIEWS

Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance

(2015) Karol Ramirez et al.   BRAIN BEHAVIOR AND IMMUNITY

Fever and sickness behavior: Friend or foe?

(2015) L.M. Harden et al.   BRAIN BEHAVIOR AND IMMUNITY

Feeding the beast: Can microglia in the senescent brain be regulated by diet?

(2015) Rodney W. Johnson   BRAIN BEHAVIOR AND IMMUNITY

Antidepressant Self-Discontinuation: Results From the Collaborative Psychiatric Epidemiology Surveys

(2015) Hillary Samples et al.   PSYCHIATRIC SERVICES

Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study

(2015) Ju-Young Shin et al.   BMJ-British Medical Journal

Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study

(2015) Ju-Young Shin et al.   BMJ-British Medical Journal

Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?

(2015) Andrew H. Miller et al.   JAMA Psychiatry

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

PATHOPHYSIOLOGY OF DEPRESSION: DO WE HAVE ANY SOLID EVIDENCE OF INTEREST TO CLINICIANS?

(2015) GREGOR HASLER   World Psychiatry

Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials

(2014) Farhad Faridhosseini et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Managing the side effects associated with commonly used treatments for bipolar depression

(2014) David E. Kemp   JOURNAL OF AFFECTIVE DISORDERS

Inflammatory Depression: A Trifecta of Trouble

(2014) Charles L. Raison   JOURNAL OF CLINICAL PSYCHIATRY

PlasmaL-Tryptophan Concentration in Major Depressive Disorder

(2014) Shintaro Ogawa et al.   JOURNAL OF CLINICAL PSYCHIATRY

The Immune System and Electroconvulsive Therapy for Depression

(2014) Sinan Guloksuz et al.   JOURNAL OF ECT

Effect of a Selective Cyclooxygenase Type 2 Inhibitor Celecoxib on Depression Associated with Obesity in Mice: An Approach Using Behavioral Tests

(2014) Yeshwant Kurhe et al.   NEUROCHEMICAL RESEARCH

Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

(2014) Jonathan Savitz et al.   NEUROPSYCHOPHARMACOLOGY

Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression

(2014) George Anderson et al.   Pharmacological Reports

Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture

(2014) Ewa Obuchowicz et al.   Pharmacological Reports

The Effects of Mind-Body Therapies on the Immune System: Meta-Analysis

(2014) Nani Morgan et al.   PLoS One

Inflamed moods: A review of the interactions between inflammation and mood disorders

(2014) Joshua D. Rosenblat et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Jump-starting natural resilience reverses stress susceptibility

(2014) A. Friedman   SCIENCE

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

NSAIDs Are Associated with Lower Depression Scores in Patients with Osteoarthritis

(2013) Rupa L. Iyengar et al.   AMERICAN JOURNAL OF MEDICINE

Re-establishment of Anxiety in Stress-Sensitized Mice Is Caused by Monocyte Trafficking from the Spleen to the Brain

(2013) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Tryptophan metabolism and immunogenetics in major depression: A role for interferon-γ gene

(2013) Aye Mu Myint et al.   BRAIN BEHAVIOR AND IMMUNITY

The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study

(2013) Jonas Hannestad et al.   BRAIN BEHAVIOR AND IMMUNITY

The association between depressive symptoms, cognitive function, and inflammation in major depression

(2013) Jesper Krogh et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial Dysregulation in Psychiatric Disease

(2013) Luciana Romina Frick et al.   Clinical & Developmental Immunology

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS

(2013) Andrew H. Miller et al.   DEPRESSION AND ANXIETY

Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus

(2013) Silvia Alboni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: Results of a randomized double-blind, placebo-controlled clinical trial

(2013) Mohammad Taraz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies

(2013) Vyara Valkanova et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroinflammation and psychiatric illness

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

The Pro-inflammatory Cytokine TNF-α Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes

(2013) Sandra Malynn et al.   NEUROCHEMICAL RESEARCH

Depression after myocardial infarction: TNF-α-induced alterations of the blood–brain barrier and its putative therapeutic implications

(2013) Hui Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cause-Specific Cardiovascular Risk Associated with Nonsteroidal Anti-Inflammatory Drugs among Myocardial Infarction Patients - A Nationwide Study

(2013) Anne-Marie Schjerning Olsen et al.   PLoS One

Synergistic Effects of Celecoxib and Bupropion in a Model of Chronic Inflammation-Related Depression in Mice

(2013) Izaque S. Maciel et al.   PLoS One

Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial

(2013) André R. Brunoni et al.   PSYCHOPHARMACOLOGY

Depression and Oxidative Stress

(2013) Priya Palta et al.   PSYCHOSOMATIC MEDICINE

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

Dysregulated relationship of inflammation and oxidative stress in major depression

(2012) B.J. Rawdin et al.   BRAIN BEHAVIOR AND IMMUNITY

Depression as an evolutionary strategy for defense against infection

(2012) Sherry Anders et al.   BRAIN BEHAVIOR AND IMMUNITY

Kynurenines: from the perspective of major psychiatric disorders

(2012) Aye M. Myint   FEBS Journal

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Molecular imaging of microglia/macrophages in the brain

(2012) Sriram Venneti et al.   GLIA

The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder

(2012) Piotr Gałecki et al.   JOURNAL OF AFFECTIVE DISORDERS

Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study

(2012) Seyed-Hesameddin Abbasi et al.   JOURNAL OF AFFECTIVE DISORDERS

Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system

(2012) L.A. Carvalho et al.   JOURNAL OF AFFECTIVE DISORDERS

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

(2012) Hyangin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression

(2012) Michael Maes   METABOLIC BRAIN DISEASE

Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression

(2012) R. Massart et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway

(2012) Michael Maes et al.   PSYCHIATRY RESEARCH

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice

(2012) Eric S. Wohleb et al.   PSYCHONEUROENDOCRINOLOGY

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Aspirin decreases the risk of depression in older men with high plasma homocysteine

(2012) O P Almeida et al.   Translational Psychiatry

Association of depressive disorders, depression characteristics and antidepressant medication with inflammation

(2012) N Vogelzangs et al.   Translational Psychiatry

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

(2012) S J Sukoff Rizzo et al.   Translational Psychiatry

Complementary Use of Tai Chi Chih Augments Escitalopram Treatment of Geriatric Depression: A Randomized Controlled Trial

(2011) Helen Lavretsky et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Celecoxib or Naproxen Treatment Does Not Benefit Depressive Symptoms in Persons Age 70 and Older: Findings From a Randomized Controlled Trial

(2011) Cynthia Fields et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Escitalopram reduces circulating pro-inflammatory cytokines and improves depressive behavior without affecting sleep in a rat model of post-cardiac infarct depression

(2011) Thierno Madjou Bah et al.   BEHAVIOURAL BRAIN RESEARCH

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

Triple reuptake inhibitors for treating subtypes of major depressive disorder: the monoamine hypothesis revisited

(2011) Jolanda Prins et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bidirectional association between depression and obesity in middle-aged and older women

(2011) A Pan et al.   INTERNATIONAL JOURNAL OF OBESITY

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Impact of citalopram on the HPA system. A study of the combined DEX/CRH test in 30 unipolar depressed patients

(2011) Tom Bschor et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Is Depression an Inflammatory Disorder?

(2011) Charles L. Raison et al.   Current Psychiatry Reports

Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study

(2010) J. Cavanagh et al.   ANNALS OF THE RHEUMATIC DISEASES

Overweight, Obesity, and Depression

(2010) Floriana S. Luppino et al.   ARCHIVES OF GENERAL PSYCHIATRY

Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

(2010) Saba Aïd et al.   BIOCHIMIE

Neural aspects of immunomodulation: Focus on the vagus nerve

(2010) Julian F. Thayer et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia activation in the hypothalamic PVN following myocardial infarction

(2010) Indrajeetsinh Rana et al.   BRAIN RESEARCH

Maintenance therapy of celecoxib for major depression with mimicking neuropsychological dysfunction

(2010) Chun-Yen Chen et al.   GENERAL HOSPITAL PSYCHIATRY

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

ASPIRIN USE, DEPRESSION, AND COGNITIVE IMPAIRMENT IN LATER LIFE: THE HEALTH IN MEN STUDY

(2010) Osvaldo P. Almeida et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Glucocorticoids, cytokines and brain abnormalities in depression

(2010) Patricia A. Zunszain et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression

(2010) Cai Song et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

(2010) Richard C. Shelton et al.   PROGRESS IN NEUROBIOLOGY

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Clinical Implications of the Cytokine Hypothesis of Depression: The Association between Use of Statins and Aspirin and the Risk of Major Depression

(2010) Julie A. Pasco et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Cytokines and Glucocorticoid Receptor Signaling

(2009) Thaddeus W. W. Pace et al.   Annals of the New York Academy of Sciences

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial

(2009) Shahin Akhondzadeh et al.   DEPRESSION AND ANXIETY

Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain

(2009) Jian-You Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

(2009) Jennifer M. Loftis et al.   NEUROBIOLOGY OF DISEASE

Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression

(2009) Reiji Yoshimura et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Association of myocardial infarctions with COX-2 inhibition may be related to immunomodulation towards a Th1 response resulting in atheromatous plaque instability: an evidence-based interpretation

(2009) I. T. Padol et al.   RHEUMATOLOGY

Pro-inflammatory biomakers in depression: Treatment with venlafaxine

(2009) John E. Piletz et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Is Regular Exercise a Friend or Foe of the Aging Immune System? A Systematic Review

(2008) Derek A Haaland et al.   CLINICAL JOURNAL OF SPORT MEDICINE

PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders

(2008) Janine Doorduin et al.   CURRENT PHARMACEUTICAL DESIGN

Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder

(2008) María Eugenia Hernández et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: Effects on proinflammatory cytokines and acute phase protein levels

(2008) Dimitris Tousoulis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effects of Yoga on Inflammation and Exercise Capacity in Patients With Chronic Heart Failure

(2008) Paula R. Pullen et al.   JOURNAL OF CARDIAC FAILURE

Differential microglial activation between acute stress and lipopolysaccharide treatment

(2008) Shuei Sugama et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2

(2008) Saba Aid et al.   Journal of Neuroinflammation

Effects of bupropion augmentation on pro-inflammatory cytokines in escitalopram-resistant patients with major depressive disorder

(2008) T Eller et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury

(2007) Sang-Ho Choi et al.   FASEB JOURNAL

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Differences in cytokines between non-suicidal patients and suicidal patients in major depression

(2007) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder

(2007) Triin Eller et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH