Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance
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Title
Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance
Authors
Keywords
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Journal
Molecular Cancer
Volume 18, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-03-30
DOI
10.1186/s12943-019-0994-2
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Note: Only part of the references are listed.- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- (2018) Ana Costa et al. CANCER CELL
- Tumor–Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer
- (2018) Daoxiang Zhang et al. CANCER RESEARCH
- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma
- (2018) Javier Vaquero et al. CLINICAL CANCER RESEARCH
- Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion
- (2018) Yu Ren et al. Molecular Cancer
- Phenotype molding of stromal cells in the lung tumor microenvironment
- (2018) Diether Lambrechts et al. NATURE MEDICINE
- Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
- (2018) Pernilla Roswall et al. NATURE MEDICINE
- Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
- (2018) Yen-An Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Associated Fibroblasts: The Architects of Stroma Remodeling
- (2018) Alice Santi et al. PROTEOMICS
- Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance
- (2018) Yun Che et al. Cell Death & Disease
- Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
- (2018) Aurélie S. Cazet et al. Nature Communications
- Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
- (2018) Maria Apicella et al. Cell Metabolism
- Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming
- (2018) Rajeev Mishra et al. JOURNAL OF CLINICAL INVESTIGATION
- Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
- (2018) Kristiaan J. Lenos et al. NATURE CELL BIOLOGY
- HGF-mediated crosstalk between cancer-associated fibroblasts and MET-unamplified gastric cancer cells activates coordinated tumorigenesis and metastasis
- (2018) Xusheng Ding et al. Cell Death & Disease
- Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma
- (2018) Cindy Neuzillet et al. JOURNAL OF PATHOLOGY
- Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7
- (2018) Binbin Yu et al. Cell Death & Disease
- A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma
- (2018) Ankit Kumar Patel et al. Oncogenesis
- Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin
- (2017) Begum Erdogan et al. JOURNAL OF CELL BIOLOGY
- EMT and MET: necessary or permissive for metastasis?
- (2017) Mohit Kumar Jolly et al. Molecular Oncology
- A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
- (2017) Anna Labernadie et al. NATURE CELL BIOLOGY
- IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma
- (2017) Y Qiao et al. ONCOGENE
- Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity
- (2017) Nicolas Skrypek et al. TRENDS IN GENETICS
- Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis
- (2017) Bi-bo Tan et al. TUMOR BIOLOGY
- Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling
- (2017) Yuanzhen Sun et al. TUMOR BIOLOGY
- Transforming growth factor β as regulator of cancer stemness and metastasis
- (2016) Claudia Bellomo et al. BRITISH JOURNAL OF CANCER
- Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors
- (2016) Lei Miao et al. CANCER RESEARCH
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
- (2016) Lifeng Yang et al. Cell Metabolism
- Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
- (2016) Heather M. Brechbuhl et al. CLINICAL CANCER RESEARCH
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
- (2016) Philippe Gascard et al. GENES & DEVELOPMENT
- Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells
- (2016) Tze-Sian Chan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways
- (2016) J A Somarelli et al. ONCOGENE
- Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
- (2016) T Yu et al. ONCOGENE
- Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells
- (2016) K E Richards et al. ONCOGENE
- Cancer stem cells and chemoresistance: The smartest survives the raid
- (2016) Jihe Zhao PHARMACOLOGY & THERAPEUTICS
- Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
- (2016) Chi Lam Au Yeung et al. Nature Communications
- Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling
- (2016) Eunice Yuen Ting Lau et al. Cell Reports
- Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
- (2015) A. Lo et al. CANCER RESEARCH
- Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
- (2015) Alexandre Calon et al. NATURE GENETICS
- LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer
- (2015) X Xue et al. ONCOGENE
- TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT
- (2015) Junlong Zhuang et al. Scientific Reports
- Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization
- (2015) Yaiza del Pozo Martin et al. Cell Reports
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- CAR T Cells for Solid Tumors
- (2014) Sunitha Kakarla et al. CANCER JOURNAL
- Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs
- (2014) S. Pennacchietti et al. CANCER RESEARCH
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- (2014) Paolo Luraghi et al. CANCER RESEARCH
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways
- (2014) Mirjam C. Boelens et al. CELL
- CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis
- (2014) Matilde Todaro et al. Cell Stem Cell
- Fibroblast heterogeneity in the cancer wound
- (2014) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Insidious Changes in Stromal Matrix Fuel Cancer Progression
- (2014) Fayth L. Miles et al. MOLECULAR CANCER RESEARCH
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Carcinoma-associated fibroblasts provide operational flexibility in metastasis
- (2014) Olivier De Wever et al. SEMINARS IN CANCER BIOLOGY
- Fibroblasts in fibrosis: novel roles and mediators
- (2014) Ryan T. Kendall et al. Frontiers in Pharmacology
- Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
- (2013) Y Yu et al. BRITISH JOURNAL OF CANCER
- Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma
- (2013) Daniela Elena Costea et al. CANCER RESEARCH
- Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
- (2013) Edward W. Roberts et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
- (2013) Fiorenza Lotti et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
- (2013) L.-C. S. Wang et al. Cancer Immunology Research
- Targeting Tumor Architecture to Favor Drug Penetration: A New Weapon to Combat Chemoresistance in Pancreatic Cancer?
- (2012) Man Yu et al. CANCER CELL
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
- (2012) T. Fiaschi et al. CANCER RESEARCH
- Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
- (2012) Valbona Luga et al. CELL
- Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells
- (2012) Ahmed F. Salem et al. CELL CYCLE
- Regulation of EMT by TGFβ in cancer
- (2012) Carl-Henrik Heldin et al. FEBS LETTERS
- Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
- (2012) Ravid Straussman et al. NATURE
- Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
- (2012) Yu Sun et al. NATURE MEDICINE
- Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
- (2012) Héctor Peinado et al. NATURE MEDICINE
- TGFβ signalling in context
- (2012) Joan Massagué NATURE REVIEWS MOLECULAR CELL BIOLOGY
- EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice
- (2012) Anne-Pierre Morel et al. PLoS Genetics
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
- (2011) Michael Quante et al. CANCER CELL
- Non-Smad signaling pathways
- (2011) Yabing Mu et al. CELL AND TISSUE RESEARCH
- Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis
- (2010) Claudia Chiodoni et al. CANCER AND METASTASIS REVIEWS
- Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness
- (2010) E. Giannoni et al. CANCER RESEARCH
- Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
- (2010) Rajnish A. Gupta et al. NATURE
- Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
- (2010) P. M. Gilbert et al. SCIENCE
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
- (2009) Kandice R. Levental et al. CELL
- Cancer stem cells: mirage or reality?
- (2009) Piyush B Gupta et al. NATURE MEDICINE
- The Extracellular Matrix: Not Just Pretty Fibrils
- (2009) R. O. Hynes SCIENCE
- TGFβ in Cancer
- (2008) Joan Massagué CELL
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
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