Article
Biochemistry & Molecular Biology
Giovanna M. Bernal, Longtao Wu, David J. Voce, Ralph R. Weichselbaum, Bakhtiar Yamini
Summary: This study found that the p52 subunit increases in the nucleus of cells during senescence, and factors in the conditioned media play a role in promoting p52 nuclear translocation. Additionally, mature p52 can induce cellular senescence. These findings support the observation of increased p52 in aged tissue and suggest that p52 contributes to organismal aging.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li
Summary: A novel circRNA, circIKBKB, was significantly upregulated in bone-metastatic breast cancer tissues. CircIKBKB enhanced the ability of breast cancer cells to induce bone pre-metastatic niche formation by promoting osteoclastogenesis and activating the NF-kappa B pathway. Inhibiting circIKBKB expression effectively suppressed breast cancer bone metastasis, indicating a potential therapeutic strategy.
Review
Medicine, General & Internal
Shangwei Zhong, Changhao Huang, Zhikang Chen, Zihua Chen, Jun-Li Luo
Summary: Castration-resistant prostate cancer (CRPC) develops from the transformation of androgen-dependent (AD) prostate cancer (PCa) to androgen-independent (AI) PCa under androgen deprivation therapy (ADT). This forced evolutionary process allows AI PCa cells to selectively and dominantly proliferate, making PCa cells and the tumor microenvironment (TME) adapt and reprogram under ADT. Currently, there are no effective therapeutic methods available for the treatment of CRPC, highlighting the importance of targeting inflammatory signaling for the emergence and maintenance of CRPC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Mihael Vucur, Ahmed Ghallab, Anne T. Schneider, Arlind Adili, Mingbo Cheng, Mirco Castoldi, Michael T. Singer, Veronika Buettner, Leonie S. Keysberg, Lena Kuesgens, Marlene Kohlhepp, Boris Goerg, Suchira Gallage, Jose Efren Barragan Avila, Kristian Unger, Claus Kordes, Anne-Laure Leblond, Wiebke Albrecht, Sven H. Loosen, Carolin Lohr, Markus S. Joerdens, Anne Babler, Sikander Hayat, David Schumacher, Maria T. Koenen, Olivier Govaere, Mark Boekschoten, Simone Joers, Carlos Villacorta-Martin, Vincenzo Mazzaferro, Josep M. Llovet, Ralf Weiskirchen, Jakob N. Kather, Patrick Starlinger, Michael Trauner, Mark Luedde, Lara R. Heij, Ulf P. Neumann, Verena Keitel, Johannes G. Bode, Rebekka K. Shneider, Frank Tacke, Bodo Levkau, Twan Lammers, Georg Fluegen, Theodore Alexandrov, Amy L. Collins, Glyn Nelson, Fiona Oakley, Derek A. Mann, Christoph Roderburg, Thomas Longerich, Achim Weber, Augusto Villanueva, Andre L. Samson, James M. Murphy, Rafael Kramann, Fabian Geisler, Ivan G. Costa, Jan G. Hengstle, Mathias Heikenwalder, Tom Luedde
Summary: A molecular switch in hepatocytes can reprogram between two forms of necroptosis signaling, which fundamentally impacts immune responses and hepatocarcinogenesis.
Article
Oncology
Jhih-Yun Ho, Hsin-Ying Lu, Hsing-Hsien Cheng, Yu-Chieh Kuo, Yu-Lin Amy Lee, Chia-Hsiung Cheng
Summary: The study showed that higher UBE2S expression in lung adenocarcinomas leads to increased binding with I kappa B alpha to activate NF-kappa B signaling and promote adenocarcinoma cell metastasis. UBE2S may serve as a potential therapeutic target for lung adenocarcinomas.
Article
Biochemistry & Molecular Biology
Marwa M. Abu-Serie, Noha H. Habashy
Summary: Relapse and drug resistance in leukemia can be overcome by targeting leukemia-initiating stem/progenitor cells (LICs). This study evaluated the anti-leukemic effect of royal jelly (RJ) components, particularly MRJP2, which showed higher growth inhibitory activity against leukemia cell lines and suppressed oncogenes associated with LICs. Furthermore, MRJP2 demonstrated greater apoptosis-inducing activity and inhibited metastasis markers and LIC survival. These findings suggest that MRJP2 can be a promising therapeutic agent for both myeloid and lymphoid leukemia.
Article
Biochemistry & Molecular Biology
Feng Tang, Hua Yu, Xia Wang, Jiageng Shi, Zhizhuang Chen, Hao Wang, Ziyu Wan, Qiqi Fu, Xuan Hu, Yisha Zuhaer, Tao Liu, Zhonghua Yang, Jianping Peng
Summary: NCAPG is overexpressed in bladder cancer, and its knockdown can inhibit cell proliferation through the inhibition of the NF-kappa B signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xue Li, Quan Jiang, Guiyu Song, Mahsa Nouri Barkestani, Qianxun Wang, Shaoxun Wang, Matthew Fan, Caodi Fang, Bo Jiang, Justin Johnson, Arnar Geirsson, George Tellides, Jordan S. Pober, Dan Jane-Wit
Summary: The ZFYVE21-Rubicon-RNF34 (ZRR) signaling complex localizes on endosomes and modulates complement-mediated inflammasome activity, promoting the release of IL-1 and tissue injury. The ZRR complex increases the activation of endosome-associated caspase-1, potentially serving as a therapeutic target for attenuating inflammasome-mediated tissue injury.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yiyang Li, Huanshuai Guan, Run Tian, Ning Kong, Guanzhi Liu, Zhe Li, Kunzheng Wang, Pei Yang
Summary: Accelerating repair of bone defects is of clinical significance due to the increased prevalence of trauma, tumor, and infections in bone. Excess inflammation has been found to impair bone marrow mesenchymal stem cells' ability to differentiate into osteoblasts, and pro-inflammatory factors like TNF-alpha and NF-kappa B further hinder osteoblastogenesis. However, melatonin has been shown to inhibit TNF alpha/NF-kappa B expression and promote bone formation through the Wnt/beta-catenin signaling pathway. This study aimed to investigate the effect of melatonin on TNF alpha/NF-kappa B-inhibited osteoblastogenesis and bone formation, and the results showed that melatonin treatment increased the number of osteoblasts and inhibited TNF alpha/NF-kappa B signaling through upregulation of miR-335-5p expression.
Article
Biotechnology & Applied Microbiology
Dan Chen, Li Shi, Dingfu Zhong, Ying Nie, Yi Yang, Dong Liu
Summary: The role of circ_0002019 in gastric cancer (GC) was investigated in this study. It was found that circ_0002019 was highly expressed in GC tissues and cells. Silencing circ_0002019 suppressed the proliferation, migration, and invasion of GC cells. Mechanistically, circ_0002019 activated the NF-κB pathway by increasing the stability of TNFAIP6 mRNA through PTBP1. These findings indicate that circ_0002019 plays a critical regulatory role in the progression of GC.
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Oncology
Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu, Mingzhi Zhang
Summary: The study reveals an EZH2-SOX9-TNFRSF11A axis in regulating NF-kappa B signaling in PCa cells. Combination therapy of EZH2 inhibitors and BAY11-7082 may be an effective approach for treating PCa patients in the future.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hee Suk Kim, Yongjin Kim, Min Jae Lim, Yun-Gyu Park, Serk In Park, Jeongwon Sohn
Review
Biochemistry & Molecular Biology
Young Mi Whang, Seung Pil Jung, Meyoung-Kon Kim, In Ho Chang, Serk In Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Dentistry, Oral Surgery & Medicine
Ji Suk Shim, Hee Chul Kim, Serk In Park, Hyung Jin Yun, Jae Jun Ryu
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2019)
Article
Clinical Neurology
H. Kim, K. -J. Park, B. -K. Ryu, D. -H. Park, D. -S. Kong, K. Chong, Y. -S. Chae, Y. -G. Chung, S. I. Park, S. -H. Kang
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2020)
Article
Endocrinology & Metabolism
Kyung-Hun Lee, Kyoung Jin Lee, Tae-Yong Kim, Febby Hutomo, Hyun Jin Sun, Gi Jeong Cheon, Serk In Park, Sun Wook Cho, Seock-Ah Im
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Petra Popovics, Wisam N. Awadallah, Sarah E. Kohrt, Thomas C. Case, Nicole L. Miller, Emily A. Ricke, Wei Huang, Marisol Ramirez-Solano, Qi Liu, Chad M. Vezina, Robert J. Matusik, William A. Ricke, Magdalena M. Grabowska
Article
Biochemistry & Molecular Biology
Seung-Hoon Lee, Yeon-Ju Lee, Serk In Park, Jung-Eun Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Oncology
Guoliang Li, Thanigaivelan Kanagasabai, Wenfu Lu, Mike R. Zou, Shang-Min Zhang, Sherly Celada, Michael G. Izban, Qi Liu, Tao Lu, Billy R. Ballard, Xinchun Zhou, Samuel E. Adunyah, Robert J. Matusik, Qin Yan, Zhenbang Chen
Article
Oncology
Sarah E. Kohrt, Wisam N. Awadallah, Robert A. Phillips, Thomas C. Case, Renjie Jin, Jagpreet S. Nanda, Xiuping Yu, Peter E. Clark, Yajun Yi, Robert J. Matusik, Philip D. Anderson, Magdalena M. Grabowska
Summary: A short hairpin RNA screen identified 11 genes supporting enzalutamide resistance, with validation experiments confirming the roles of ACAT1, MAP3K11, and PSMD12 in vitro. Inhibition of MAP3K11 in combination with enzalutamide led to increased cell death, suggesting potential therapeutic strategies for castration-resistant prostate cancer.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Young Mi Whang, Da Hyeon Yoon, Gwang Yong Hwang, Hoyub Yoon, Serk In Park, Young Wook Choi, In Ho Chang
Article
Multidisciplinary Sciences
Mini Jeong, Mi Hyeon Jeong, Jung Eun Kim, Serin Cho, Kyoung Jin Lee, Serkin Park, Jeongwon Sohn, Yun Gyu Park
Summary: The study reveals that the mTORC1/S6K pathway inhibits an Akt/PLK1 signaling axis, causing TCTP protein stabilization and conferring resistance to DNA-damaging agents in lung cancer cells. Inducing TCTP degradation with rapamycin enhances the efficacy of DNA-damaging drugs without consideration of p53 functional status.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Jeong-Ki Kim, Seong-Beom Han, Serk In Park, In-San Kim, Dong-Hwee Kim
Summary: Alternatively activated or M2 macrophages play a vital role in anti-inflammation, wound healing, and tissue repair. This study demonstrates that M2 activation requires mechanical cues from the extracellular microenvironment, and matrix rigidity-dependent macrophage spreading is mediated by F-actin formation. The study also identifies a new mechanosensing function of STAT6 in M2 activation.
Article
Biochemical Research Methods
Eun Jung Lee, Seungpil Jung, Kyong Hwa Park, Serk In Park
Summary: Multi-color flow cytometry is a standard approach in immunophenotyping clinical samples. This article describes a clinical study on quantifying MDSC in breast cancer patient blood samples and provides detailed procedures for study design, sample logistics and handling, staining, and flow cytometric analysis. The results of the study showed an increase in both PMN and M-MDSC populations in patients with bone metastasis. This work presents a versatile and practical protocol for measuring MDSC in patient blood samples.
JOURNAL OF IMMUNOLOGICAL METHODS
(2022)
Review
Endocrinology & Metabolism
Min-Kyoung Song, Serk In Park, Sun Wook Cho
Summary: Bone metastasis is a common site of spread for various solid tumors, leading to significant health problems and mortality in patients. One major challenge is the lack of biomarkers for early detection and monitoring of therapeutic responses. Current imaging techniques have limitations in detecting early lesions and accurately monitoring disease progression. Therefore, there is a need for the development of novel blood biomarkers. This review article provides an overview of the protein- and cell-based biomarkers that are currently used or under development for bone metastasis in clinical practice.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Cell & Tissue Engineering
Eun Jung Lee, Kyoung Jin Lee, Seungpil Jung, Kyong Hwa Park, Serk In Park
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells in the tumor microenvironment. The mechanism of MDSC mobilization from the bone marrow (BM) is still not fully understood. This study investigated the role of PTH1R activation in BM stromal cells in MDSC mobilization. It was found that PTH1R activation led to the release of monocytic (M-) MDSCs from murine BM by promoting binding between M-MDSCs and osteoblasts. The activation of Src family kinase and upregulation of proteases ADAM-17 and MMP7 were also involved in this process.