Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection

Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo

(2020) Barbara Ruder et al.   PLoS One

Acute Infectious Diarrhea and Gastroenteritis in Children

(2020) Ivan D. Florez et al.   Current Infectious Disease Reports

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

(2020) Azucena Salas et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

(2020) Shauna M. Crowley et al.   PLoS Pathogens

Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease

(2020) Friederike Cordes et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

(2020) José Carlos Santos et al.   Nature Communications

Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

(2020) Daniel Fisch et al.   Cell Reports

Type I and II Interferon Signatures Can Predict the Response to Anti-TNF Agents in Inflammatory Bowel Disease Patients: Involvement of the Microbiota

(2020) Clio P Mavragani et al.   INFLAMMATORY BOWEL DISEASES

Long-term safety and tolerability of oral tofacitinib in patients with Crohn’s disease: results from a phase 2, open-label, 48-week extension study

(2019) Julián Panés et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Interleukin 21 collaborates with interferon-γ for the optimal expression of interferon-stimulated genes and enhances protection against enteric microbial infection

(2019) Shahram Solaymani-Mohammadi et al.   PLoS Pathogens

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

Differential Regulation of Type I and Type III Interferon Signaling

(2019) Megan L. Stanifer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

ZBP1 mediates interferon-induced necroptosis

(2019) Daowei Yang et al.   Cellular & Molecular Immunology

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production

(2019) Shuai Wang et al.   mBio

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium

(2019) R. Paul Wilson et al.   PLoS Pathogens

Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis

(2019) Daniel Fisch et al.   EMBO JOURNAL

Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease

(2019) Claudia Günther et al.   GASTROENTEROLOGY

JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?

(2019) Silvio Danese et al.   GUT

Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment

(2019) Christina Eftychi et al.   IMMUNITY

Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation

(2019) Iris Stolzer et al.   INFLAMMATORY BOWEL DISEASES

Host Cell Death Responses to Non-typhoidal Salmonella Infection

(2019) Madeleine A. Wemyss et al.   Frontiers in Immunology

IFN-I and IL-22 mediate protective effects of intestinal viral infection

(2019) Jessica A Neil et al.   Nature Microbiology

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure

(2019) Miriam Bittel et al.   Cell Death & Disease

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

(2018) Joseph Sarhan et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Treatment Perspectives in Crohn’s Disease

(2018) Marcel Vetter et al.   DIGESTION

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Adaptive immune education by gut microbiota antigens

(2018) Qing Zhao et al.   IMMUNOLOGY

A Nonpyroptotic IFN-γ–Triggered Cell Death Mechanism in Nonphagocytic Cells PromotesSalmonellaClearance In Vivo

(2018) Justin P. Ingram et al.   JOURNAL OF IMMUNOLOGY

Interferon Lambda: Toward a Dual Role in Cancer

(2018) Ahmed Lasfar et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

(2018) Konrad Aden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells

(2018) Barbara Ruder et al.   Mucosal Immunology

Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis

(2018) Shiloh R. Lueschow et al.   PLoS One

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

(2018) Anna S. Lehle et al.   GASTROENTEROLOGY

Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8

(2018) Veronika Kanderova et al.   HAEMATOLOGICA

The association of Inflammatory Bowel diseases with autoimmune disorders: a population-based report from the epi-IIRN

(2018) Shahar Bar Yehuda et al.   Journal of Crohns & Colitis

Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia

(2018) Luciana H. Osaki et al.   JOURNAL OF PATHOLOGY

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease

(2017) Mircea T. Chiriac et al.   GASTROENTEROLOGY

Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials

(2017) Julian Panés et al.   GUT

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Type 1 Interferon in the Human Intestine—A Co-ordinator of the Immune Response to the Microbiota

(2017) Edward M. Giles et al.   INFLAMMATORY BOWEL DISEASES

Type I interferon enhances necroptosis ofSalmonellaTyphimurium–infected macrophages by impairing antioxidative stress responses

(2017) Nina Judith Hos et al.   JOURNAL OF CELL BIOLOGY

Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial

(2017) Séverine Vermeire et al.   LANCET

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

(2017) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

NEMO Links Nuclear Factor-κB to Human Diseases

(2017) Gunter Maubach et al.   TRENDS IN MOLECULAR MEDICINE

Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

(2017) Deann T. Snyder et al.   Journal of Immunology Research

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

(2017) Andrea Majoros et al.   Frontiers in Immunology

Early type I Interferon response induces upregulation of human β-defensin 1 during acute HIV-1 infection

(2017) Björn Corleis et al.   PLoS One

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

The Roles of Type I Interferon in Bacterial Infection

(2016) Gayle M. Boxx et al.   Cell Host & Microbe

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Chemokine and cytokine levels in inflammatory bowel disease patients

(2016) Udai P. Singh et al.   CYTOKINE

The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases

(2016) Consuelo M. López de Padilla et al.   GENE

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

Crosstalk between microbiota, pathogens and the innate immune responses

(2016) Claudia Günther et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

(2016) Teresa L. M. Thurston et al.   Nature Communications

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Type I IFN family members: Similarity, differences and interaction

(2015) Maria Rosaria Capobianchi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

SalmonellaTyphimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively

(2015) Darren J. Perkins et al.   JOURNAL OF IMMUNOLOGY

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase Functions in Cell Death and Disease: Figure 1.

(2015) David R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Activation of Intestinal Epithelial Stat3 Orchestrates Tissue Defense during Gastrointestinal Infection

(2015) Nadine Wittkopf et al.   PLoS One

Type I Interferons Function as Autocrine and Paracrine Factors to Induce Autotaxin in Response to TLR Activation

(2015) Jianwen Song et al.   PLoS One

A Phase 2 Study of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients With Crohn’s Disease

(2014) William J. Sandborn et al.   Clinical Gastroenterology and Hepatology

Interferons: Success in anti-viral immunotherapy

(2014) Fan-ching Lin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Esophageal Epithelial Resistance

(2014) Claudia Günther et al.   DIGESTIVE DISEASES

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

(2014) Claudia Günther et al.   GUT

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration

(2014) Markus Tschurtschenthaler et al.   GUT

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

(2014) Judith Behnsen et al.   IMMUNITY

The role of type I interferons in intestinal infection, homeostasis, and inflammation

(2014) Hyeseon Cho et al.   IMMUNOLOGICAL REVIEWS

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Regulation and pathophysiological role of epithelial turnover in the gut

(2014) Claudia Günther et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Fine tuning type I interferon responses

(2013) Paul J. Hertzog et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Caspase-11: The driving factor for noncanonical inflammasomes

(2013) Elena Viganò et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Rotavirus NSP1 Protein Inhibits Interferon-Mediated STAT1 Activation

(2013) A. Sen et al.   JOURNAL OF VIROLOGY

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interferon-regulated gene signature is elevated in subacute cutaneous lupus erythematosus and discoid lupus erythematosus and correlates with the cutaneous lupus area and severity index score

(2012) I. Braunstein et al.   BRITISH JOURNAL OF DERMATOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Complex Roles of Caspases in the Pathogenesis of Inflammatory Bowel Disease

(2012) Christoph Becker et al.   GASTROENTEROLOGY

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

(2012) Megan Raetz et al.   NATURE IMMUNOLOGY

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

The Two Faces of Interferon-  in Cancer

(2011) M. R. Zaidi et al.   CLINICAL CANCER RESEARCH

NEMO is a key component of NF-κB– and IRF-3–dependent TLR3-mediated immunity to herpes simplex virus

(2011) Magali Audry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interferons in Autoimmune and Inflammatory Diseases: Regulation and Roles

(2011) Divaker Choubey et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

(2011) R. J. Thapa et al.   MOLECULAR AND CELLULAR BIOLOGY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection

(2011) Pascal Songhet et al.   PLoS One

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inborn errors of anti-viral interferon immunity in humans

(2011) Vanessa Sancho-Shimizu et al.   Current Opinion in Virology

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

Dynamics of growth and dissemination of Salmonella in vivo

(2010) Kathryn G. Watson et al.   CELLULAR MICROBIOLOGY

Rapid onset of ulcerative colitis after treatment with interferon β1a in a patient with multiple sclerosis

(2010) Yasar Tuna et al.   Journal of Crohns & Colitis

Involvement of Interferon-γ in Bowel Disease Pathogenesis by Nitric Oxide Pathway: A Study in Algerian Patients

(2010) Hayet Rafa et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia

(2010) Leigh A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

(2009) Jason W. Bauer et al.   ARTHRITIS AND RHEUMATISM

Interferon beta-1a for the maintenance of remission in patients with Crohn's disease: results of a phase II dose-finding study

(2009) Claudia Pena Rossi et al.   BMC GASTROENTEROLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-α/β, IFN-γ, and IFN-λ in host defense

(2009) Shen-Ying Zhang et al.   IMMUNOLOGICAL REVIEWS

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

A partial form of recessive STAT1 deficiency in humans

(2009) Ariane Chapgier et al.   JOURNAL OF CLINICAL INVESTIGATION

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

The IκB kinase complex: master regulator of NF-κB signaling

(2008) Laura A. Solt et al.   IMMUNOLOGIC RESEARCH

The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases

(2008) Saleh Al-Muhsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens