Type 1 Interferon in the Human Intestine—A Co-ordinator of the Immune Response to the Microbiota

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

(2017) Kapil Saxena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Genetic variation in STAT4 predicts response to interferon-α therapy for hepatitis B e antigen-positive chronic hepatitis B

(2016) De-Ke Jiang et al.   HEPATOLOGY

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production

(2016) Jin-Young Yang et al.   IMMUNITY

Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease

(2016) E M Giles et al.   Mucosal Immunology

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces

(2016) Chigusa Nakahashi-Oda et al.   NATURE IMMUNOLOGY

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

(2016) Elisa Deriu et al.   PLoS Pathogens

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

IFN-α/β Receptor Signaling Promotes Regulatory T Cell Development and Function under Stress Conditions

(2015) Amina Metidji et al.   JOURNAL OF IMMUNOLOGY

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

(2015) Mahima Swamy et al.   Nature Communications

Type I interferons have opposing effects during the emergence and recovery phases of colitis

(2014) Isabella Rauch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration

(2014) Markus Tschurtschenthaler et al.   GUT

Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity

(2014) Haifeng C. Xu et al.   IMMUNITY

Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

(2014) Josh Crouse et al.   IMMUNITY

Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice

(2014) Marijana Basic et al.   INFLAMMATORY BOWEL DISEASES

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infection

(2014) L. P. Shornick et al.   JOURNAL OF IMMUNOLOGY

TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression

(2014) Silvia Stockinger et al.   JOURNAL OF IMMUNOLOGY

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

(2014) Jessica A. Pane et al.   PLoS Pathogens

Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

(2013) Tadaomi Kawashima et al.   IMMUNITY

Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell-Mediated Colitis

(2013) A. Kole et al.   JOURNAL OF IMMUNOLOGY

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

Resident viruses and their interactions with the immune system

(2013) Breck A Duerkop et al.   NATURE IMMUNOLOGY

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

An Interferon Paradox

(2013) P. M. Odorizzi et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development

(2012) Masahiro Yamamoto et al.   BMC GENOMICS

Type I Interferons Maintain Foxp3 Expression and T-Regulatory Cell Functions Under Inflammatory Conditions in Mice

(2012) Shee Eun Lee et al.   GASTROENTEROLOGY

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

Induction of type I IFNs by intracellular DNA-sensing pathways

(2012) Taner Cavlar et al.   IMMUNOLOGY AND CELL BIOLOGY

Modulation of T-cell function by type I interferon

(2012) David F Tough   IMMUNOLOGY AND CELL BIOLOGY

Topical Treatment with the Toll-like Receptor Agonist DIMS0150 Has Potential for Lasting Relief of Symptoms in Patients with Chronic Active Ulcerative Colitis by Restoring Glucocorticoid Sensitivity

(2012) Eugen Musch et al.   INFLAMMATORY BOWEL DISEASES

CD69 Regulates Type I IFN-Induced Tolerogenic Signals to Mucosal CD4 T Cells That Attenuate Their Colitogenic Potential

(2012) K. Radulovic et al.   JOURNAL OF IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis

(2011) D. C. Baumgart et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Toll-like receptor-7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis

(2011) Satheesh K. Sainathan et al.   INFLAMMATORY BOWEL DISEASES

Literature review in cases with exacerbation of ulcerative colitis induced by treatment with interferon and/or ribavirin

(2011) Takuya Watanabe et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut

(2011) Natalia Shulzhenko et al.   NATURE MEDICINE

Localized Delivery of Interferon-β by Lactobacillus Exacerbates Experimental Colitis

(2011) Adelle P. McFarland et al.   PLoS One

Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract

(2011) D. Parker et al.   mBio

Interferon-β modulates type 1 immunity during influenza virus infection

(2010) Jae-Kwang Yoo et al.   ANTIVIRAL RESEARCH

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells

(2010) C. Hofmann et al.   GUT

Suppression of inflammation in ulcerative colitis by interferon- -1a is accompanied by inhibition of IL-13 production

(2010) P. J. Mannon et al.   GUT

Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll-like receptor-2-dependent mechanism

(2010) Gudrun Weiss et al.   IMMUNOLOGY

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Commensal Escherichia coli Reduces Epithelial Apoptosis through IFN- A-Mediated Induction of Guanylate Binding Protein-1 in Human and Murine Models of Developing Intestine

(2010) J. Mirpuri et al.   JOURNAL OF IMMUNOLOGY

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Bifidobacterium bifidum Actively Changes the Gene Expression Profile Induced by Lactobacillus acidophilus in Murine Dendritic Cells

(2010) Gudrun Weiss et al.   PLoS One

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis

(2009) Arthur A. Vandenbark et al.   JOURNAL OF NEUROIMMUNOLOGY

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Maladie de Crohn au cours d’une sclérose en plaques : rôle de l’interféron bêta

(2009) M. Samson et al.   REVUE DE MEDECINE INTERNE

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

CpG Motifs of Bacterial DNA Exert Protective Effects in Mouse Models of IBD by Antigen-Independent Tolerance Induction

(2008) Andre Bleich et al.   GASTROENTEROLOGY

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

Interferon-alpha controls IL-17 expression in vitro and in vivo

(2008) Alexander R. Moschen et al.   IMMUNOBIOLOGY

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling

(2008) Gabriella Regis et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY