Essential histone chaperones collaborate to regulate transcription and chromatin integrity

Structure and mechanism of the RNA polymerase II transcription machinery

(2020) Allison C. Schier et al.   GENES & DEVELOPMENT

Interplay among ATP-Dependent Chromatin Remodelers Determines Chromatin Organisation in Yeast

(2020) Hemant K. Prajapati et al.   Biology-Basel

The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae

(2020) Natalia I Reim et al.   NUCLEIC ACIDS RESEARCH

The role of FACT in managing chromatin: disruption, assembly, or repair?

(2020) Tim Formosa et al.   NUCLEIC ACIDS RESEARCH

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors

(2019) Haruhiko Ehara et al.   SCIENCE

A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation

(2019) Rajaraman Gopalakrishnan et al.   NUCLEIC ACIDS RESEARCH

Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae

(2019) Laura L. McCullough et al.   GENETICS

The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

(2019) Christine E Cucinotta et al.   NUCLEIC ACIDS RESEARCH

Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications

(2019) Célia Jeronimo et al.   Cell Reports

FACT caught in the act of manipulating the nucleosome

(2019) Yang Liu et al.   NATURE

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

(2019) Magdalena Murawska et al.   MOLECULAR CELL

Acetylation-Dependent Recruitment of the FACT Complex and Its Role in Regulating Pol II Occupancy Genome-Wide inSaccharomyces cerevisiae

(2018) Rakesh Pathak et al.   GENETICS

Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription

(2018) Raghuvar Dronamraju et al.   MOLECULAR CELL

Acetylation-Dependent Recruitment of the FACT Complex and Its Role in Regulating Pol II Occupancy Genome-Wide inSaccharomyces cerevisiae

(2018) Rakesh Pathak et al.   GENETICS

Structure and function of the histone chaperone FACT – Resolving FACTual issues

(2018) Katerina Gurova et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in Saccharomyces cerevisiae

(2018) Alison K. Thurston et al.   GENETICS

Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

(2018) Takayuki Nojima et al.   MOLECULAR CELL

Spt6 Is Required for the Fidelity of Promoter Selection

(2018) Stephen M. Doris et al.   MOLECULAR CELL

Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

(2018) Han-Wen Chang et al.   Science Advances

Residues in the Nucleosome Acidic Patch Regulate Histone Occupancy and Are Important for FACT Binding in Saccharomyces cerevisiae

(2017) Amelia J. Hodges et al.   GENETICS

Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches

(2017) Christopher Warren et al.   JOURNAL OF MOLECULAR BIOLOGY

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation

(2017) Ameet Shetty et al.   MOLECULAR CELL

Subgenic Pol II interactomes identify region‐specific transcription elongation regulators

(2017) Kevin M Harlen et al.   Molecular Systems Biology

Histone chaperone networks shaping chromatin function

(2017) Colin M. Hammond et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

(2017) John B. Crickard et al.   NUCLEIC ACIDS RESEARCH

The elongation factor Spn1 is a multi-functional chromatin binding protein

(2017) Sha Li et al.   NUCLEIC ACIDS RESEARCH

Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes

(2017) Nicole Uwimana et al.   NUCLEIC ACIDS RESEARCH

A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

(2017) Matthew A Sdano et al.   eLife

Residues in the Nucleosome Acidic Patch Regulate Histone Occupancy and Are Important for FACT Binding in Saccharomyces cerevisiae

(2017) Amelia J. Hodges et al.   GENETICS

Noncoding Transcription Is a Driving Force for Nucleosome Instability inspt16Mutant Cells

(2016) Jianxun Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription

(2016) Wei Li et al.   MOLECULAR CELL

Dynamics of Nucleosome Positioning Maturation following Genomic Replication

(2016) Pauline Vasseur et al.   Cell Reports

Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters

(2016) Christopher A. Lavender et al.   PLoS Genetics

Native Elongating Transcript Sequencing Reveals Human Transcriptional Activity at Nucleotide Resolution

(2015) Andreas Mayer et al.   CELL

The Abundant Histone Chaperones Spt6 and FACT Collaborate to Assemble, Inspect, and Maintain Chromatin Structure in Saccharomyces cerevisiae

(2015) L. McCullough et al.   GENETICS

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations

(2015) Célia Jeronimo et al.   MOLECULAR CELL

Quality control of transcription start site selection by nonsense-mediated-mRNA decay

(2015) Christophe Malabat et al.   eLife

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts

(2014) E. Herrera-Moyano et al.   GENES & DEVELOPMENT

Gene promoters dictate histone occupancy within genes

(2013) Roberto Perales et al.   EMBO JOURNAL

Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing

(2013) J. A. Arribere et al.   GENOME RESEARCH

Quantitative Proteomics Demonstrates That the RNA Polymerase II Subunits Rpb4 and Rpb7 Dissociate during Transcriptional Elongation

(2013) Amber L. Mosley et al.   MOLECULAR & CELLULAR PROTEOMICS

A Compendium of Nucleosome and Transcript Profiles Reveals Determinants of Chromatin Architecture and Transcription

(2013) Harm van Bakel et al.   PLoS Genetics

The Spt4–Spt5 complex: A multi-faceted regulator of transcription elongation

(2012) Grant A. Hartzog et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Snakemake--a scalable bioinformatics workflow engine

(2012) J. Koster et al.   BIOINFORMATICS

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

Set3 HDAC Mediates Effects of Overlapping Noncoding Transcription on Gene Induction Kinetics

(2012) TaeSoo Kim et al.   CELL

Short nucleosome repeats impose rotational modulations on chromatin fibre folding

(2012) Sarah J Correll et al.   EMBO JOURNAL

Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange

(2012) Michaela Smolle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nascent transcript sequencing visualizes transcription at nucleotide resolution

(2011) L. Stirling Churchman et al.   NATURE

Direct regulation of nucleosome density by the conserved AAA-ATPase Yta7

(2011) L. M. Lombardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26

(2010) Marie-Laure Diebold et al.   EMBO JOURNAL

Discovery of Mutations in Saccharomyces cerevisiae by Pooled Linkage Analysis and Whole-Genome Sequencing

(2010) S. R. Birkeland et al.   GENETICS

Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions

(2010) Nina C. Hubner et al.   JOURNAL OF CELL BIOLOGY

Extracting gene function from protein–protein interactions using Quantitative BAC InteraCtomics (QUBIC)

(2010) Nina C. Hubner et al.   METHODS

Control of Chromatin Structure by Spt6: Different Consequences in Coding and Regulatory Regions

(2010) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure and Biological Importance of the Spn1-Spt6 Interaction, and Its Regulatory Role in Nucleosome Binding

(2010) Seth M. McDonald et al.   MOLECULAR CELL

Uniform transitions of the general RNA polymerase II transcription complex

(2010) Andreas Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H3K4 and K36 Methylation, Chd1 and Rpd3S Oppose the Functions of Saccharomyces cerevisiae Spt4-Spt5 in Transcription

(2009) T. K. Quan et al.   GENETICS

Histone Chaperone Spt16 Promotes Redeposition of the Original H3-H4 Histones Evicted by Elongating RNA Polymerase

(2009) Adil Jamai et al.   MOLECULAR CELL

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

(2008) S. M. Yoh et al.   GENES & DEVELOPMENT

Roles for Ctk1 and Spt6 in Regulating the Different Methylation States of Histone H3 Lysine 36

(2008) M. L. Youdell et al.   MOLECULAR AND CELLULAR BIOLOGY

H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation

(2008) Alastair B. Fleming et al.   MOLECULAR CELL

Chromatin- and Transcription-Related Factors Repress Transcription from within Coding Regions throughout the Saccharomyces cerevisiae Genome

(2008) Vanessa Cheung et al.   PLOS BIOLOGY