The role of FACT in managing chromatin: disruption, assembly, or repair?

The FACT Histone Chaperone: Tuning Gene Transcription in the Chromatin Context to Modulate Plant Growth and Development

(2020) Klaus D. Grasser   Frontiers in Plant Science

Chromatin replication and epigenetic cell memory

(2020) Kathleen R. Stewart-Morgan et al.   NATURE CELL BIOLOGY

The replisome guides nucleosome assembly during DNA replication

(2020) Wenshuo Zhang et al.   Cell and Bioscience

Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation

(2020) Poorva Sandlesh et al.   iScience

Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters

(2020) Fuquan Chen et al.   NUCLEIC ACIDS RESEARCH

FACT and Ash1 promote long-range and bidirectional nucleosome eviction at the HO promoter

(2020) Yaxin Yu et al.   NUCLEIC ACIDS RESEARCH

Histone chaperone FACT FAcilitates Chromatin Transcription: mechanistic and structural insights

(2020) Keda Zhou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Transcription-driven chromatin repression of Intragenic transcription start sites

(2019) Mathias Nielsen et al.   PLoS Genetics

Evidence for a bind-then-bend mechanism for architectural DNA binding protein yNhp6A

(2019) Manas Kumar Sarangi et al.   NUCLEIC ACIDS RESEARCH

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae

(2019) Laura L. McCullough et al.   GENETICS

The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

(2019) Christine E Cucinotta et al.   NUCLEIC ACIDS RESEARCH

A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing

(2019) Theophilus T. Tettey et al.   Cell Reports

Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications

(2019) Célia Jeronimo et al.   Cell Reports

Electron Microscopy of Yeast FACT Protein Complex

(2019) M.G. Karlova et al.   MICROSCOPY AND MICROANALYSIS

Control of DNA replication timing in the 3D genome

(2019) Claire Marchal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FACT caught in the act of manipulating the nucleosome

(2019) Yang Liu et al.   NATURE

FACT mediates cohesin function on chromatin

(2019) Jonay Garcia-Luis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

(2019) Gary LeRoy et al.   Science Advances

Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance

(2019) Sahana Holla et al.   CELL

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

(2019) Magdalena Murawska et al.   MOLECULAR CELL

Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs

(2018) Elimelech Nesher et al.   CANCER RESEARCH

Widespread and precise reprogramming of yeast protein–genome interactions in response to heat shock

(2018) Vinesh Vinayachandran et al.   GENOME RESEARCH

Functional roles of the DNA-binding HMGB domain in the histone chaperone FACT in nucleosome reorganization

(2018) Laura L. McCullough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level

(2018) Ping Chen et al.   MOLECULAR CELL

Structure and function of the histone chaperone FACT – Resolving FACTual issues

(2018) Katerina Gurova et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

(2018) Haiyun Gan et al.   MOLECULAR CELL

The histone chaperone complex FACT promotes proliferative switch of G 0 cancer cells

(2018) Ling Bi et al.   INTERNATIONAL JOURNAL OF CANCER

Spt6 Is Required for the Fidelity of Promoter Selection

(2018) Stephen M. Doris et al.   MOLECULAR CELL

FACT Inhibition Blocks Induction But Not Maintenance of Pluripotency

(2018) Zuolian Shen et al.   STEM CELLS AND DEVELOPMENT

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

(2017) Christoph F. Kurat et al.   MOLECULAR CELL

Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes

(2017) Nicole Uwimana et al.   NUCLEIC ACIDS RESEARCH

The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors

(2017) Wojciech Antosz et al.   PLANT CELL

Histone chaperone Spt16p is required for heterochromatin mediated silencing in budding yeast

(2017) Xiaowei Yan et al.   Protein & Cell

Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

(2017) Ana Tamarkin-Ben-Harush et al.   eLife

Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy

(2017) Maria Valieva et al.   Cancers

The CENP-T/-W complex is a binding partner of the histone chaperone FACT

(2016) Lisa Prendergast et al.   GENES & DEVELOPMENT

Integrated molecular mechanism directing nucleosome reorganization by human FACT

(2016) Yasuo Tsunaka et al.   GENES & DEVELOPMENT

Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

(2016) Roberta Visconti et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Noncoding Transcription Is a Driving Force for Nucleosome Instability inspt16Mutant Cells

(2016) Jianxun Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription

(2016) Wei Li et al.   MOLECULAR CELL

Large-scale ATP-independent nucleosome unfolding by a histone chaperone

(2016) Maria E Valieva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation

(2016) Tareq Hossan et al.   STEM CELLS

Large-scale ATP-independent nucleosome unfolding by a histone chaperone

(2016) Maria E Valieva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly

(2016) Jiayi Yang et al.   Cell Reports

Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription

(2015) Chin-Chi Chen et al.   DEVELOPMENTAL CELL

The Abundant Histone Chaperones Spt6 and FACT Collaborate to Assemble, Inspect, and Maintain Chromatin Structure in Saccharomyces cerevisiae

(2015) L. McCullough et al.   GENETICS

A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin

(2015) J. Peter Svensson et al.   GENOME RESEARCH

Pluripotency Transcription Factor Oct4 Mediates Stepwise Nucleosome Demethylation and Depletion

(2015) Arvind Shakya et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations

(2015) Célia Jeronimo et al.   MOLECULAR CELL

FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs

(2015) David J. Kemble et al.   MOLECULAR CELL

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells

(2015) Henry Garcia et al.   Oncotarget

A Chromatin-Based Mechanism for Limiting Divergent Noncoding Transcription

(2014) Sebastian Marquardt et al.   CELL

Replicative Stress Induces Intragenic Transcription of the ASE1 Gene that Negatively Regulates Ase1 Activity

(2014) Kelly McKnight et al.   CURRENT BIOLOGY

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

(2014) Gary M.R. Deyter et al.   GENES & DEVELOPMENT

A Role for FACT in Repopulation of Nucleosomes at Inducible Genes

(2014) Warren P. Voth et al.   PLoS One

The FACT Histone Chaperone Guides Histone H4 Into Its Nucleosomal Conformation in Saccharomyces cerevisiae

(2013) L. McCullough et al.   GENETICS

Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT

(2013) David J. Kemble et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myogenin Recruits the Histone Chaperone Facilitates Chromatin Transcription (FACT) to Promote Nucleosome Disassembly at Muscle-specific Genes

(2013) Alexandra A. Lolis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II

(2013) F.-K. Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic Replisome Components Cooperate to Process Histones During Chromosome Replication

(2013) Magdalena Foltman et al.   Cell Reports

A Compendium of Nucleosome and Transcript Profiles Reveals Determinants of Chromatin Architecture and Transcription

(2013) Harm van Bakel et al.   PLoS Genetics

Catch me if you can

(2013) Maria Hondele et al.   Nucleus

A map of nucleosome positions in yeast at base-pair resolution

(2012) Kristin Brogaard et al.   NATURE

Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro

(2012) B. G. Kuryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Mutant Versions of the Spt16 Histone Chaperone That Are Defective for Transcription-Coupled Nucleosome Occupancy in Saccharomyces cerevisiae

(2012) Sarah J. Hainer et al.   G3-Genes Genomes Genetics

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

(2012) Thanasis Margaritis et al.   PLoS Genetics

The role of FACT in making and breaking nucleosomes

(2011) Tim Formosa   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Insight Into the Mechanism of Nucleosome Reorganization From Histone Mutants That Suppress Defects in the FACT Histone Chaperone

(2011) Laura McCullough et al.   GENETICS

The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization

(2011) Duane D. Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Chaperone FACT Coordinates Nucleosome Interaction through Multiple Synergistic Binding Events

(2011) Duane D. Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Histone Mutants That Are Defective for Transcription-Coupled Nucleosome Occupancy

(2011) S. J. Hainer et al.   MOLECULAR AND CELLULAR BIOLOGY

Two surfaces on the histone chaperone Rtt106 mediate histone binding, replication, and silencing

(2011) R. M. Zunder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curaxins: Anticancer Compounds That Simultaneously Suppress NF- B and Activate p53 by Targeting FACT

(2011) A. V. Gasparian et al.   Science Translational Medicine

Nhp6: A small but powerful effector of chromatin structure in Saccharomyces cerevisiae

(2010) David J. Stillman   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Intergenic transcription causes repression by directing nucleosome assembly

(2010) S. J. Hainer et al.   GENES & DEVELOPMENT

Uniform transitions of the general RNA polymerase II transcription complex

(2010) Andreas Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FACT Prevents the Accumulation of Free Histones Evicted from Transcribed Chromatin and a Subsequent Cell Cycle Delay in G1

(2010) Macarena Morillo-Huesca et al.   PLoS Genetics

FACT facilitates chromatin transcription by RNA polymerases I and III

(2009) Joanna L Birch et al.   EMBO JOURNAL

The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters

(2009) Shinya Takahata et al.   EMBO JOURNAL

FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation

(2009) Monica Ransom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CENP-H–containing Complex Facilitates Centromere Deposition of CENP-A in Cooperation with FACT and CHD1

(2009) Masahiro Okada et al.   MOLECULAR BIOLOGY OF THE CELL

FACT and Asf1 Regulate Nucleosome Dynamics and Coactivator Binding at the HO Promoter

(2009) Shinya Takahata et al.   MOLECULAR CELL

Histone Chaperone Spt16 Promotes Redeposition of the Original H3-H4 Histones Evicted by Elongating RNA Polymerase

(2009) Adil Jamai et al.   MOLECULAR CELL

yFACT Induces Global Accessibility of Nucleosomal DNA without H2A-H2B Displacement

(2009) Hua Xin et al.   MOLECULAR CELL

Regulon-Specific Control of Transcription Elongation across the Yeast Genome

(2009) Vicent Pelechano et al.   PLoS Genetics

Acetylated Lysine 56 on Histone H3 Drives Chromatin Assembly after Repair and Signals for the Completion of Repair

(2008) Chin-Chuan Chen et al.   CELL

H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation

(2008) Alastair B. Fleming et al.   MOLECULAR CELL

The FACT Spt16 “peptidase” domain is a histone H3–H4 binding module

(2008) Tobias Stuwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin- and Transcription-Related Factors Repress Transcription from within Coding Regions throughout the Saccharomyces cerevisiae Genome

(2008) Vanessa Cheung et al.   PLOS BIOLOGY

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

(2008) Sushma Shivaswamy et al.   PLOS BIOLOGY