Biological functions of fucose in mammals

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

(2017) Taia T. Wang et al.   SCIENCE

Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway

(2016) Lijie Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel p53 target geneFUCA1encodes a fucosidase and regulates growth and survival of cancer cells

(2016) Issei Ezawa et al.   CANCER SCIENCE

Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion

(2016) Brian A. Benz et al.   DEVELOPMENTAL BIOLOGY

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

(2016) Jessika Valero-González et al.   Nature Chemical Biology

Obinutuzumab in hematologic malignancies: Lessons learned to date

(2015) Tim Illidge et al.   CANCER TREATMENT REVIEWS

Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism

(2015) Deepika Vasudevan et al.   CURRENT BIOLOGY

O-fucosylation of CCN1 is required for its secretion

(2015) Yuki Niwa et al.   FEBS LETTERS

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

(2015) Tzu-Chun Cheng et al.   Oncotarget

2-Fluoro-L-Fucose Is a Metabolically Incorporated Inhibitor of Plant Cell Wall Polysaccharide Fucosylation

(2015) Jose A. Villalobos et al.   PLoS One

Prognostic relevance of glycosylation-associated genes in breast cancer

(2014) Karin Milde-Langosch et al.   BREAST CANCER RESEARCH AND TREATMENT

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

(2014) Tu Anh N. Pham et al.   Cell Host & Microbe

Novel roles for O-linked glycans in protein folding

(2014) Deepika Vasudevan et al.   GLYCOCONJUGATE JOURNAL

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

(2014) Julia Müller et al.   PLoS One

Analysis of POFUT1 Gene Mutation in a Chinese Family with Dowling-Degos Disease

(2014) Mingfei Chen et al.   PLoS One

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Mutations in POFUT1, Encoding Protein O-fucosyltransferase 1, Cause Generalized Dowling-Degos Disease

(2013) Ming Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in PDGFRB Cause Autosomal-Dominant Infantile Myofibromatosis

(2013) John A. Martignetti et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Syndrome of Microcornea, Myopic Chorioretinal Atrophy, and Telecanthus (MMCAT) Is Caused by Mutations inADAMTS18

(2013) Mohammed A. Aldahmesh et al.   HUMAN MUTATION

Decreased Expression of Alpha-L-Fucosidase Gene FUCA1 in Human Colorectal Tumors

(2013) Olalla Otero-Estévez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer

(2013) SATOSHI YOKOTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Development of orally active inhibitors of protein and cellular fucosylation

(2013) N. M. Okeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

(2013) P. C. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Multidomain Protein MEGF8 Identify a Carpenter Syndrome Subtype Associated with Defective Lateralization

(2012) Stephen R.F. Twigg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome

(2012) Barbara Kloeckener-Gruissem et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

6-Alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin Type-1 repeats by protein O-fucosyltransferases 1 and 2

(2012) E. Al-Shareffi et al.   GLYCOBIOLOGY

LTBP2 mutations cause Weill-Marchesani and Weill-Marchesani-like syndrome and affect disruptions in the extracellular matrix

(2012) Ramona Haji-Seyed-Javadi et al.   HUMAN MUTATION

Fucose sensing regulates bacterial intestinal colonization

(2012) Alline R. Pacheco et al.   NATURE

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

(2012) Tracey M Gloster et al.   Nature Chemical Biology

Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores

(2012) Steven E. Boyden et al.   NEUROGENETICS

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

(2012) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic click-labeling with a fucose analog reveals pectin delivery, architecture, and dynamics in Arabidopsis cell walls

(2012) C. T. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Screening for Inhibitors of Sialyl- and Fucosyltransferases

(2011) Cory D. Rillahan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycans as cancer biomarkers

(2011) Barbara Adamczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

(2011) D. Yao et al.   BLOOD

A novel missense mutation close to the charge-stabilizing system in a patient with congenital factor VII deficiency

(2011) Minghua Jiang et al.   BLOOD COAGULATION & FIBRINOLYSIS

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A chemoenzymatic approach toward the identification of fucosylated glycoproteins and mapping of N-glycan sites

(2011) Ta-Wei Liu et al.   GLYCOBIOLOGY

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z−) agrin

(2011) Ricardo A. Maselli et al.   HUMAN GENETICS

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD)

(2011) Clare V Logan et al.   NATURE GENETICS

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine

(2011) Pirjo Wacklin et al.   PLoS One

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype

(2011) P. Rausch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Sperm Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida

(2011) P.-C. Pang et al.   SCIENCE

Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study

(2010) G. Edgren et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mutations in SCARF2 Are Responsible for Van Den Ende-Gupta Syndrome

(2010) Natascia Anastasio et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin α5β1 with the Lewis Y-structure on transfection of the α1,2-fucosyltransferase gene

(2010) Li-Mei Yan et al.   BIOCHIMIE

Identification of a novel homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive retinitis pigmentosa

(2010) Yukan Huang et al.   BMC Medical Genetics

Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium

(2010) B. M. Wolpin et al.   CANCER RESEARCH

Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma

(2010) T. Ishii et al.   CLINICAL CANCER RESEARCH

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation

(2010) Jianguang Du et al.   DEVELOPMENTAL BIOLOGY

Core fucosylation and  2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia

(2010) R. Saldova et al.   GLYCOBIOLOGY

A homozygous mutation in LTBP2 causes isolated microspherophakia

(2010) Arun Kumar et al.   HUMAN GENETICS

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

(2010) Dermot P.B. McGovern et al.   HUMAN MOLECULAR GENETICS

EYS is a major gene for rod-cone dystrophies in France

(2010) Isabelle Audo et al.   HUMAN MUTATION

Slc35c2 Promotes Notch1 Fucosylation and Is Required for Optimal Notch Signaling in Mammalian Cells

(2010) Linchao Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Efficient Approach to the Discovery of Potent Inhibitors against Glycosyltransferases

(2010) Kensaku Hosoguchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

In VivoImaging ofCaenorhabditis elegansGlycans

(2009) Scott T. Laughlin et al.   ACS Chemical Biology

A Homozygous Mutation in ADAMTSL4 Causes Autosomal-Recessive Isolated Ectopia Lentis

(2009) Dina Ahram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Homozygous Mutations in ADAMTS10 and ADAMTS17 Cause Lenticular Myopia, Ectopia Lentis, Glaucoma, Spherophakia, and Short Stature

(2009) Jose Morales et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of an Agrin Mutation that Causes Congenital Myasthenia and Affects Synapse Function

(2009) Caroline Huzé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Null Mutations in LTBP2 Cause Primary Congenital Glaucoma

(2009) Manir Ali et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb

(2009) Heather E. Murrey et al.   BIOCHEMISTRY

Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene

(2009) A. D. Paterson et al.   BLOOD

Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain

(2009) S. Ohata et al.   DEVELOPMENT

Deficiency of GMDS Leads to Escape from NK Cell-Mediated Tumor Surveillance Through Modulation of TRAIL Signaling

(2009) Kenta Moriwaki et al.   GASTROENTEROLOGY

Fucose Is on the TRAIL of Colon Cancer

(2009) Robert S. Haltiwanger   GASTROENTEROLOGY

Familial factor VII deficiency with foetal and neonatal fatal cerebral haemorrhage associated with homozygosis to Gly180Arg mutation

(2009) D. LANDAU et al.   HAEMOPHILIA

Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice

(2009) X. Wang et al.   JOURNAL OF BIOCHEMISTRY

Two Pathways for Importing GDP-fucose into the Endoplasmic Reticulum Lumen Function Redundantly in theO-Fucosylation of Notch inDrosophila

(2009) Hiroyuki O. Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-Linked Thrombophilia with a Mutant Factor IX (Factor IX Padua)

(2009) Paolo Simioni et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role for  -L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells

(2009) T.-W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Polymorphism in THBS2 that Affects Alternative Splicing and MMP Binding Is Associated with Lumbar-Disc Herniation

(2008) Yuichiro Hirose et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of a 2 Mb Human Ortholog of Drosophila eyes shut/spacemaker that Is Mutated in Patients with Retinitis Pigmentosa

(2008) Rob W.J. Collin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

E-selectin receptors on human leukocytes

(2008) L. Nimrichter et al.   BLOOD

Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc

(2008) S. Yakubenia et al.   BLOOD

Branched N-glycans regulate the biological functions of integrins and cadherins

(2008) Yanyang Zhao et al.   FEBS Journal

Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme

(2008) Wendy E. Kutz et al.   HUMAN MUTATION

Activating NOTCH3 mutation in a patient with small-vessel-disease of the Brain

(2008) Charles Fouillade et al.   HUMAN MUTATION

Comprehensive clinical and molecular assessment of 32 probands with congenital contractural arachnodactyly: Report of 14 novel mutations and review of the literature

(2008) Bert L. Callewaert et al.   HUMAN MUTATION

Roles of Pofut1 andO-Fucose in Mammalian Notch Signaling

(2008) Mark Stahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pofut1 is required for the proper localization of the Notch receptor during mouse development

(2008) Yoshiaki Okamura et al.   MECHANISMS OF DEVELOPMENT

O-fucosylation of muscle agrin determines its ability to cluster acetylcholine receptors

(2008) Mi-Lyang Kim et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation

(2008) Carine Le Goff et al.   NATURE GENETICS

EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa

(2008) Mai M Abd El-Aziz et al.   NATURE GENETICS

Fucosylated haptoglobin is a novel marker for pancreatic cancer: Detailed analyses of oligosaccharide structures

(2008) Eiji Miyoshi et al.   PROTEOMICS

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE

Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth

(2007) Zhenbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH