Humoral immune responses to AAV gene therapy in the ocular compartment
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Humoral immune responses to
AAV
gene therapy in the ocular compartment
Authors
Keywords
-
Journal
BIOLOGICAL REVIEWS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2021-04-10
DOI
10.1111/brv.12718
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer
- (2020) Helena Costa Verdera et al. MOLECULAR THERAPY
- Capsid-specific removal of circulating antibodies to adeno-associated virus vectors
- (2020) Berangere Bertin et al. Scientific Reports
- The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation
- (2020) Thai Thanh Hoang Thi et al. Polymers
- IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
- (2020) Christian Leborgne et al. NATURE MEDICINE
- Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene
- (2019) Céline Bouquet et al. JAMA Ophthalmology
- AAV Engineering Identifies a Species Barrier That Highlights a Portal to the Brain
- (2019) Luk H. Vandenberghe MOLECULAR THERAPY
- Impact of age and motor function in a phase 1/2A study of infants with SMA Type 1 receiving single-dose gene replacement therapy
- (2019) Linda P. Lowes et al. PEDIATRIC NEUROLOGY
- Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation–Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials
- (2019) Albert M. Maguire et al. OPHTHALMOLOGY
- Ocular inflammatory response to intravitreal injection of AAV vector: relative contribution of genome and capsid
- (2019) Adrian Timmers et al. HUMAN GENE THERAPY
- Anterior chamber associated immune deviation to cytosolic neural antigens avoids self-reactivity after optic nerve injury and polarizes the retinal environment to an anti-inflammatory profile
- (2019) L. Martínez-Alcantar et al. JOURNAL OF NEUROIMMUNOLOGY
- Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A
- (2019) Lluis Samaranch et al. Science Translational Medicine
- Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders
- (2019) Alireza Shahryari et al. Frontiers in Genetics
- Prevalence of Anti-Adeno-Associated Virus Immune Responses in International Cohorts of Healthy Donors
- (2019) Anita Kruzik et al. Molecular Therapy-Methods & Clinical Development
- Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells
- (2019) Jamie L. Shirley et al. MOLECULAR THERAPY
- TLR9 signaling mediates adaptive immunity following systemic AAV gene therapy
- (2019) Scott N. Ashley et al. CELLULAR IMMUNOLOGY
- Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery
- (2019) Natalie F. Nidetz et al. PHARMACOLOGY & THERAPEUTICS
- Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN
- (2018) Christian Hinderer et al. HUMAN GENE THERAPY
- The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice
- (2018) Juliette Hordeaux et al. MOLECULAR THERAPY
- Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis
- (2018) Guylène Le Meur et al. MOLECULAR THERAPY
- The Assembly-Activating Protein Promotes Stability and Interactions between AAV’s Viral Proteins to Nucleate Capsid Assembly
- (2018) Anna C. Maurer et al. Cell Reports
- Immune Privilege and Eye-Derived T-Regulatory Cells
- (2018) Hiroshi Keino et al. Journal of Immunology Research
- Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction
- (2018) Zachary Fitzpatrick et al. Molecular Therapy-Methods & Clinical Development
- Emerging Issues in AAV-Mediated In Vivo Gene Therapy
- (2018) Pasqualina Colella et al. Molecular Therapy-Methods & Clinical Development
- Dosage thresholds and influence of transgene cassette in AAV-related toxicity
- (2018) Hanen Khabou et al. HUMAN GENE THERAPY
- Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65
- (2018) Eloise Hudry et al. Molecular Therapy-Methods & Clinical Development
- Plasma cells: The programming of an antibody-secreting machine
- (2018) Julie Tellier et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Exposure to wild-type AAV drives distinct capsid immunity profiles in humans
- (2018) Klaudia Kuranda et al. JOURNAL OF CLINICAL INVESTIGATION
- Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration
- (2018) Ruslan Grishanin et al. MOLECULAR THERAPY
- Health outcomes in spinal muscular atrophy type 1 following AVXS‐101 gene replacement therapy
- (2018) Samiah Al‐Zaidy et al. PEDIATRIC PULMONOLOGY
- Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
- (2018) Amine Meliani et al. Nature Communications
- The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection
- (2018) Xi Chen et al. Frontiers in Immunology
- Gene Therapy for Spinal Muscular Atrophy: An Emerging Treatment Option for a Devastating Disease
- (2018) Vamshi K. Rao et al. Journal of Managed Care & Specialty Pharmacy
- Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial
- (2017) Céline Vandamme et al. HUMAN GENE THERAPY
- Regulatory and Exhausted T Cell Responses to AAV Capsid
- (2017) Gwladys Gernoux et al. HUMAN GENE THERAPY
- Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial
- (2017) Jeffrey S Heier et al. LANCET
- Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
- (2017) Stephen Russell et al. LANCET
- Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial
- (2017) Marc Tardieu et al. LANCET NEUROLOGY
- IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
- (2017) Stanley C. Jordan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy
- (2017) Jerry R. Mendell et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gene Therapy for Leber Hereditary Optic Neuropathy
- (2017) John Guy et al. OPHTHALMOLOGY
- Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion
- (2017) Longping Victor Tse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting
- (2017) Victoria M. Velazquez et al. Molecular Therapy-Methods & Clinical Development
- Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer
- (2017) Roland W. Herzog et al. CELLULAR IMMUNOLOGY
- Exosome-associated AAV vector as a robust and convenient neuroscience tool
- (2016) E Hudry et al. GENE THERAPY
- Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial
- (2016) Nicola G. Ghazi et al. HUMAN GENETICS
- Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV
- (2016) Jean-Charles Nault et al. MOLECULAR THERAPY
- An essential receptor for adeno-associated virus infection
- (2016) S. Pillay et al. NATURE
- Gene Therapy for Leber Hereditary Optic Neuropathy
- (2016) William J. Feuer et al. OPHTHALMOLOGY
- Cellular transduction mechanisms of adeno-associated viral vectors
- (2016) Garrett Edward Berry et al. Current Opinion in Virology
- In vivo tissue-tropism of adeno-associated viral vectors
- (2016) Arun Srivastava Current Opinion in Virology
- Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration
- (2016) Ian J. Constable et al. EBioMedicine
- 368. Optimizing Liver Transduction of the Low Seroprevalent AAV rh32.33
- (2016) MOLECULAR THERAPY
- Efficacy and Safety of rAAV2-ND4 Treatment for Leber’s Hereditary Optic Neuropathy
- (2016) Xing Wan et al. Scientific Reports
- B Cells, Antibodies, and More
- (2015) W. Hoffman et al. Clinical Journal of the American Society of Nephrology
- Strategies to circumvent humoral immunity to adeno-associated viral vectors
- (2015) Longping V Tse et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure
- (2015) B Greenberg et al. GENE THERAPY
- Enhanced Efficacy from Gene Therapy in Pompe Disease Using Coreceptor Blockade
- (2015) Sang-oh Han et al. HUMAN GENE THERAPY
- Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial
- (2015) Paul E. Monahan et al. HUMAN GENE THERAPY
- Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective
- (2015) Eric Hastie et al. HUMAN GENE THERAPY
- Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial
- (2015) Elizabeth P Rakoczy et al. LANCET
- Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
- (2015) Jean-Charles Nault et al. NATURE GENETICS
- Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
- (2015) James W.B. Bainbridge et al. NEW ENGLAND JOURNAL OF MEDICINE
- In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector
- (2015) Eric Zinn et al. Cell Reports
- Determination of Anti-Adeno-Associated Virus Vector Neutralizing Antibody Titer with anIn VitroReporter System
- (2015) Amine Meliani et al. Human Gene Therapy Methods
- Super-resolution imaging of nuclear import of adeno-associated virus in live cells
- (2015) Joseph M Kelich et al. Molecular Therapy-Methods & Clinical Development
- AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes
- (2015) Daniel J Hui et al. Molecular Therapy-Methods & Clinical Development
- AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats
- (2015) Kasey L Jackson et al. Molecular Therapy-Methods & Clinical Development
- Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity
- (2015) Lena Winstedt et al. PLoS One
- Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy
- (2014) William Wold et al. CURRENT GENE THERAPY
- Treatment strategies for inherited optic neuropathies: past, present and future
- (2014) P Yu-Wai-Man et al. EYE
- AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy
- (2014) R Thwaite et al. GENE THERAPY
- Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates
- (2014) M A Kotterman et al. GENE THERAPY
- Engineering adeno-associated viruses for clinical gene therapy
- (2014) Melissa A. Kotterman et al. NATURE REVIEWS GENETICS
- The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease
- (2014) Jennifer Müller et al. Nature Reviews Rheumatology
- Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
- (2014) D. K. Sato et al. NEUROLOGY
- AAV-Mediated Gene Therapy for Research and Therapeutic Purposes
- (2014) R. Jude Samulski et al. Annual Review of Virology
- Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors
- (2014) Etiena Basner-Tschakarjan et al. Frontiers in Immunology
- B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study
- (2014) M Corti et al. Molecular Therapy-Methods & Clinical Development
- Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects
- (2014) Kai Gao et al. Molecular Therapy-Methods & Clinical Development
- T cell responses: naïve to memory and everything in between
- (2013) Nathan D. Pennock et al. ADVANCES IN PHYSIOLOGY EDUCATION
- Protective Antiviral Antibodies that Lack Neutralizing Activity: Precedents and Evolution of Concepts
- (2013) Alan Schmaljohn CURRENT HIV RESEARCH
- Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates
- (2013) S J Gray et al. GENE THERAPY
- Immune Responses to Intramuscular Administration of Alipogene Tiparvovec (AAV1-LPLS447X) in a Phase II Clinical Trial of Lipoprotein Lipase Deficiency Gene Therapy
- (2013) Valerie Ferreira et al. HUMAN GENE THERAPY
- Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis
- (2013) Matthew S. Macauley et al. JOURNAL OF CLINICAL INVESTIGATION
- Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expression
- (2013) Christian Mueller et al. JOURNAL OF CLINICAL INVESTIGATION
- Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy
- (2013) Virginia Haurigot et al. JOURNAL OF CLINICAL INVESTIGATION
- Mapping the Structural Determinants Responsible for Enhanced T Cell Activation to the Immunogenic Adeno-Associated Virus Capsid from Isolate Rhesus 32.33
- (2013) L. E. Mays et al. JOURNAL OF VIROLOGY
- Differential Type I Interferon-dependent Transgene Silencing of Helper-dependent Adenoviral vs. Adeno-associated Viral Vectors In Vivo
- (2013) Masataka Suzuki et al. MOLECULAR THERAPY
- Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes
- (2013) Daniel J Hui et al. MOLECULAR THERAPY
- CD8+ T Cell Recognition of Epitopes Within the Capsid of Adeno-associated Virus 8–based Gene Transfer Vectors Depends on Vectors’ Genome
- (2013) Te-Lang Wu et al. MOLECULAR THERAPY
- Plasmapheresis Eliminates the Negative Impact of AAV Antibodies on Microdystrophin Gene Expression Following Vascular Delivery
- (2013) LG Chicoine et al. MOLECULAR THERAPY
- AAV8 Induces Tolerance in Murine Muscle as a Result of Poor APC Transduction, T Cell Exhaustion, and Minimal MHCI Upregulation on Target Cells
- (2013) Lauren E Mays et al. MOLECULAR THERAPY
- In Vivo-Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous
- (2013) D. Dalkara et al. Science Translational Medicine
- Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
- (2013) F. Mingozzi et al. Science Translational Medicine
- B-cell subpopulations in humans and their differential susceptibility to depletion with anti-CD20 monoclonal antibodies
- (2013) Maria J Leandro ARTHRITIS RESEARCH & THERAPY
- Humoral Immune Response to AAV
- (2013) Roberto Calcedo et al. Frontiers in Immunology
- Germinal Centers
- (2012) Gabriel D. Victora et al. Annual Review of Immunology
- Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue
- (2012) F Mingozzi et al. GENE THERAPY
- Directed evolution of novel adeno-associated viruses for therapeutic gene delivery
- (2012) M A Bartel et al. GENE THERAPY
- Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial
- (2012) D Gaudet et al. GENE THERAPY
- Germinal center selection and the development of memory B and plasma cells
- (2012) Mark J. Shlomchik et al. IMMUNOLOGICAL REVIEWS
- Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
- (2012) Arianna Moiani et al. JOURNAL OF CLINICAL INVESTIGATION
- Humoral and Cellular Capsid-Specific Immune Responses to Adeno-Associated Virus Type 1 in Randomized Healthy Donors
- (2012) P. Veron et al. JOURNAL OF IMMUNOLOGY
- Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates
- (2012) Carmen Unzu et al. Journal of Translational Medicine
- Cytoplasmic Trafficking, Endosomal Escape, and Perinuclear Accumulation of Adeno-Associated Virus Type 2 Particles Are Facilitated by Microtubule Network
- (2012) P.-J. Xiao et al. JOURNAL OF VIROLOGY
- Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B
- (2012) Federico Mingozzi et al. MOLECULAR THERAPY
- Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors
- (2012) Jozsef Karman et al. PLoS One
- AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness
- (2012) J. Bennett et al. Science Translational Medicine
- How Can HIV-Type-1-Env Immunogenicity Be Improved to Facilitate Antibody-Based Vaccine Development?
- (2011) Per Johan Klasse et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations
- (2011) Samuel G. Jacobson ARCHIVES OF OPHTHALMOLOGY
- Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine
- (2011) J H McIntosh et al. GENE THERAPY
- Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors
- (2011) Marianna Hösel et al. HEPATOLOGY
- Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors
- (2011) Steven J. Gray et al. HUMAN GENE THERAPY
- Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results
- (2011) Terence R. Flotte et al. HUMAN GENE THERAPY
- A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8
- (2011) Virginie Monteilhet et al. MOLECULAR THERAPY
- Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
- (2011) Amit C. Nathwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Activation of the NF-κB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy
- (2011) Giridhara R. Jayandharan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blood-Retinal Barrier
- (2010) José Cunha-Vaz et al. EUROPEAN JOURNAL OF OPHTHALMOLOGY
- Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors
- (2010) Sylvie Boutin et al. HUMAN GENE THERAPY
- Generation of effector CD8+ T cells and their conversion to memory T cells
- (2010) Weiguo Cui et al. IMMUNOLOGICAL REVIEWS
- Dystrophin Immunity in Duchenne's Muscular Dystrophy
- (2010) Jerry R. Mendell et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
- (2010) D. L. Mallery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Safety and Efficacy of Subretinal Readministration of a Viral Vector in Large Animals to Treat Congenital Blindness
- (2010) D. Amado et al. Science Translational Medicine
- Inhibition of nuclear entry of HPV16 pseudovirus-packaged DNA by an anti-HPV16 L2 neutralizing antibody
- (2010) Yoshiyuki Ishii et al. VIROLOGY
- AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells
- (2009) F. Mingozzi et al. BLOOD
- Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
- (2009) T. H. Mogensen CLINICAL MICROBIOLOGY REVIEWS
- Ocular immune privilege
- (2009) A W Taylor EYE
- Progress and prospects: immune responses to viral vectors
- (2009) S Nayak et al. GENE THERAPY
- Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors
- (2009) Gary C. Pien et al. JOURNAL OF CLINICAL INVESTIGATION
- Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses
- (2009) Roberto Calcedo et al. JOURNAL OF INFECTIOUS DISEASES
- Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
- (2009) Albert M Maguire et al. LANCET
- Effect of Genome Size on AAV Vector Packaging
- (2009) Zhijian Wu et al. MOLECULAR THERAPY
- Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
- (2009) M. L. Brantly et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intramuscular Administration of AAV1-Lipoprotein Lipase S447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients
- (2008) Erik S. Stroes et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"
- (2008) A. S. De Groot et al. BLOOD
- Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial
- (2008) William W. Hauswirth et al. HUMAN GENE THERAPY
- New Insights into the Early Molecular Events Underlying B Cell Activation
- (2008) Naomi E. Harwood et al. IMMUNITY
- Diverse IgG subclass responses to adeno-associated virus infection and vector administration
- (2008) Samuel L. Murphy et al. JOURNAL OF MEDICAL VIROLOGY
- Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
- (2008) A. K. Zaiss et al. JOURNAL OF VIROLOGY
- Sindbis Virus Conformational Changes Induced by a Neutralizing Anti-E1 Monoclonal Antibody
- (2008) R. Hernandez et al. JOURNAL OF VIROLOGY
- In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses
- (2008) D. Grimm et al. JOURNAL OF VIROLOGY
- Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
- (2008) Albert M. Maguire et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis
- (2008) James W.B. Bainbridge et al. NEW ENGLAND JOURNAL OF MEDICINE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started