Plasma cells: The programming of an antibody-secreting machine

Immunological memories of the bone marrow

(2018) Hyun-Dong Chang et al.   IMMUNOLOGICAL REVIEWS

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function

(2018) Virginia Andreani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function

(2018) Wing Y. Lam et al.   Cell Reports

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production

(2017) Muyao Guo et al.   JOURNAL OF IMMUNOLOGY

Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins

(2017) Rasmus Iversen et al.   Cell Reports

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR has distinct functions in generating versus sustaining humoral immunity

(2016) Derek D. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

ZBTB32 Restricts the Duration of Memory B Cell Recall Responses

(2016) Arijita Jash et al.   JOURNAL OF IMMUNOLOGY

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

(2016) Martina Minnich et al.   NATURE IMMUNOLOGY

The importance of non-HLA antibodies in transplantation

(2016) Qiuheng Zhang et al.   Nature Reviews Nephrology

Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization

(2016) Vincent Biajoux et al.   Cell Reports

New insights into B cell biology in systemic lupus erythematosus and Sjögrenʼs syndrome

(2015) Anna K. Bird et al.   CURRENT OPINION IN RHEUMATOLOGY

c-Myb is required for plasma cell migration to bone marrow after immunization or infection

(2015) Kim L. Good-Jacobson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif

(2015) Cheryl H. Rozanski et al.   JOURNAL OF IMMUNOLOGY

Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice

(2015) A Lemke et al.   Mucosal Immunology

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B 1

(2015) Jun Kunisawa et al.   Cell Reports

GenomicScape: An Easy-to-Use Web Tool for Gene Expression Data Analysis. Application to Investigate the Molecular Events in the Differentiation of B Cells into Plasma Cells

(2015) Alboukadel Kassambara et al.   PLoS Computational Biology

Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network

(2014) Kazuhiko Igarashi et al.   IMMUNOLOGICAL REVIEWS

The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity

(2014) Stéphane Chevrier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvant-specific regulation of long-term antibody responses by ZBTB20

(2014) Yinan Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTOR Activation Promotes Plasma Cell Differentiation and Bypasses XBP-1 for Immunoglobulin Secretion

(2014) Sandrine Benhamron et al.   MOLECULAR AND CELLULAR BIOLOGY

Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool

(2014) Yan-Feng Li et al.   Nature Communications

Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells

(2013) Sandrine Benhamron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

A Replicative Self-Renewal Model for Long-Lived Plasma Cells: Questioning Irreversible Cell Cycle Exit

(2013) Reuben M. Tooze   Frontiers in Immunology

High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

(2012) N. Taubenheim et al.   JOURNAL OF IMMUNOLOGY

CD28 Expressed on Malignant Plasma Cells Induces a Prosurvival and Immunosuppressive Microenvironment

(2011) J. R. Nair et al.   JOURNAL OF IMMUNOLOGY

B cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2

(2010) R. Winkelmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

(2009) Yanjun Ma et al.   CELL STRESS & CHAPERONES

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

(2009) Chih-Chi Andrew Hu et al.   EMBO JOURNAL

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

(2009) Derrick J. Todd et al.   JOURNAL OF EXPERIMENTAL MEDICINE

XBP-1-Deficient Plasmablasts Show Normal Protein Folding but Altered Glycosylation and Lipid Synthesis

(2009) A. M. McGehee et al.   JOURNAL OF IMMUNOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

(2009) S. Chevrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF4 addiction in multiple myeloma

(2008) Arthur L. Shaffer et al.   NATURE