Exosome-associated AAV vector as a robust and convenient neuroscience tool

Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1

(2015) Brian T. Hawkins et al.   BRAIN RESEARCH

Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium

(2015) Yuri Persidsky et al.   Journal of Neuroimmune Pharmacology

Stimulation-Evoked Ca2+ Signals in Astrocytic Processes at Hippocampal CA3-CA1 Synapses of Adult Mice Are Modulated by Glutamate and ATP

(2015) W. Tang et al.   JOURNAL OF NEUROSCIENCE

Disease-modifying strategies for Parkinson's disease

(2015) Lorraine V. Kalia et al.   MOVEMENT DISORDERS

Heparin affinity purification of extracellular vesicles

(2015) Leonora Balaj et al.   Scientific Reports

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Molecular Profiling of Neurons Based on Connectivity

(2014) Mats I. Ekstrand et al.   CELL

Emerging Roles of Extracellular Vesicles in the Nervous System

(2014) L. Rajendran et al.   JOURNAL OF NEUROSCIENCE

Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10

(2014) Bin Yang et al.   MOLECULAR THERAPY

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Astrocyte Ca2+ signalling: an unexpected complexity

(2014) Andrea Volterra et al.   NATURE REVIEWS NEUROSCIENCE

Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

(2014) D. M. Pegtel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mouse Gender Influences Brain Transduction by Intravascularly Administered AAV9

(2013) Casey A Maguire et al.   MOLECULAR THERAPY

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

A Single Intravenous AAV9 Injection Mediates Bilateral Gene Transfer to the Adult Mouse Retina

(2013) Alexis-Pierre Bemelmans et al.   PLoS One

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them

(2013) Sangeetha Hareendran et al.   REVIEWS IN MEDICAL VIROLOGY

A Neural Circuit for Memory Specificity and Generalization

(2013) W. Xu et al.   SCIENCE

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

Assessment of the AAV-mediated expression of channelrhodopsin-2 and halorhodopsin in brainstem neurons mediating auditory signaling

(2012) T. Shimano et al.   BRAIN RESEARCH

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

(2012) Casey A Maguire et al.   MOLECULAR THERAPY

Serial two-photon tomography for automated ex vivo mouse brain imaging

(2012) Timothy Ragan et al.   NATURE METHODS

AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

(2012) J. Bennett et al.   Science Translational Medicine

Large-scale recombinant adeno-associated virus production

(2011) R. M. Kotin   HUMAN MOLECULAR GENETICS

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

(2011) Steven J Gray et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Innate Immune Responses to AAV Vectors

(2011) Geoffrey L. Rogers et al.   Frontiers in Microbiology

Adenovirus–Adeno-Associated Virus Hybrid for Large-Scale Recombinant Adeno-Associated Virus Production

(2009) Hongwei Zhang et al.   HUMAN GENE THERAPY

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

(2009) Albert M Maguire et al.   LANCET

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS Administration of a Serotype 2 Adeno-Associated Virus Expressing CLN2 cDNA

(2008) Stefan Worgall et al.   HUMAN GENE THERAPY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY